Centenarians with good vitamin D were 1.5 X less likely to depressed

Created August 2018

The prevalence of depressive symptoms in Chinese longevous persons and its correlation with vitamin D status

BMC Geriatrics201818:198, https://doi.org/10.1186/s12877-018-0886-0

Yao Yao†, Shihui Fu†, Hao Zhang, Nan Li, Qiao Zhu, Fu Zhang, Fuxin Luan, Yali Zhao and Yao He †Contributed equally

Tiny subset of table in the PDF | | | | | | --- | --- | --- | --- | | Characteristics | Depression | No Depression | P | | Vitamin D deficiency (<20ng) | 48% | 36% | < 0.001 | | BMI kg/m2, | 17.8 | 18.5 | 0.004 | | Current alcohol drinker | 8.6% | 11.6% | 0.096 | | ADL impairments | 72% | 49% | < 0.001 | | Outdoor activities > 1 h/d, | 53% | 63.0% | 0.001 | 1.5 X more likely to be depressed if < 20 ng of Vitamin D --- * Centenarians with high vitamin D were 2.9X more likely to be functionally independent – Oct 2018 Pages listed in BOTH the categories Depression and Seniors {category} --- * * Depression category listing has items along with related searches** * Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018 * People who get little noon-day sun must supplement with Vitamin D – systematic review June 2017 * Parkinson’s disease 2 times less likely if get 2 hours of daily sun – Nov 2016 13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following {include} Additional supplements to reduce depression * How Omega-3 Fights Depression – LEF July 2016 * Depression treated somewhat by Omega-3 (St. John's Wort better) – RAND org reviews 2015 * Depression greatly reduced by taking 250 mg of Magnesium Chloride daily for 6 weeks– RCT June 2017

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Background

Hypovitaminosis D and depressive syndromes are common conditions in old adults. However, little is known about the relationship between vitamin D and depression in exceptional aged people. The objective of this study is to evaluate the relationship between vitamin D levels and depressive symptoms in Chinese longevous persons.

Methods

We used a dataset from a cross-sectional survey of a sample of Chinese longevous people with self-reported age 100 or older, including 175 men and 765 women, was conducted from June 2014 to December 2016 in Hainan Province, China. Data on demographics, lifestyle characteristics and health conditions were collected using a structured questionnaire. Anthropometrics and blood samples were obtained following the standard procedure. Depressive symptoms of the participants were assessed using a shortened version of the Geriatric Depression Scale (GDS-15). Serum vitamin D levels were measured using an automated radioimmunoassay.

Results

The prevalence of longevous persons with depressive symptoms among the sample was 32.2% (95% confidence interval: 29.7–34.7%). Serum vitamin D levels were lower in participants with depressive symptoms than in those without (20.8 ± 8.7 vs. 23.7 ± 9.7, ng/mL).

Vitamin D deficiency was an independent risk factor for depression after controlling for the potential covariates ( Odds ratio = 1.47 , 95% Confidence interval = 1.08–2.00; p = 0.014). A negative relationship between serum vitamin D levels and depressive symptoms was also detected, and the relationship remained significant after adjusting for a wide range of other covariates. The multivariate adjusted odds ratio of depressive symptoms for the lowest versus highest quartiles of vitamin D levels was 1.73 (95% confidence interval: 1.10–2.72), and the adjusted odds ratio with a 5 ng/mL decrement of serum 25OHD levels was 1.10 (95% confidence interval: 1.01–1.19).

Conclusions

This study showed an inverse association between vitamin D levels and depressive symptoms among Chinese longevous persons. Depressive symptoms should be screened in longevous persons who had vitamin D deficiency. Further studies on vitamin D supplement and prevention along with treatment of depression are needed among very old population.

Tags: Depression Seniors