Cardiovascular death reduction in dark skin migrants by just 1,000 IU of vitamin D
Can oral vitamin D prevent the cardiovascular diseases among migrants in Australia? Provider perspective using Markov modelling
Clinical and Experimental Pharmacology and Physiology, DOI: 10.1111/1440-1681.12399
Thilanga Ruwanpathirana1, Alice Owen1, Andre M.N. Renzaho2, Ella Zomer3, Manoj Gambhir4 and Christopher M. Reid1,*
The study was designed to model the effectiveness and cost effectiveness of oral Vitamin D supplementation as a primary prevention strategy for cardiovascular disease among a migrant population in Australia. It was carried out in the Community Health Service, Kensington, Melbourne. Best-case scenario analysis using a Markov model was employed to look at the health care providers’ perspective. Adult migrants who were vitamin D deficient and free from cardiovascular disease visiting the medical centre at least once during the period from 1st January 2010 to 31st December 2012 was included to the study. The blood pressure-lowering effect of vitamin D was taken from a published meta-analysis and applied in the Framingham 10 year cardiovascular risk algorithm (with and without oral vitamin D supplements) to generate the probabilities of cardiovascular events. A Markov decision model was used to estimate the provider costs associated with the events and treatments. Uncertainties were derived by Monte Carlo simulation. Vitamin D oral supplementation (1,000 IU/d) for 10 years could potentially prevent 31 (IQR 26 to 37) non-fatal and 11 (IQR 10 to 15) fatal cardiovascular events in a migrant population of 10,000 assuming the 100% compliance. The provider perspective incremental cost effectiveness per year of life saved was AU$ 3,992 (IQR 583 to 8558). This study suggests subsidised supplementation of oral vitamin D may be a cost effective intervention to reduce non-fatal and fatal cardiovascular outcomes in high-risk migrant populations