Asthma is poorly controlled if have 4 ng less Vitamin D

Created May 2019

Cross-sectional associations of vitamin D status with asthma prevalence, exacerbations, and control in New Zealand adults.

J Steroid Biochem Mol Biol. 2019 Apr;188:1-7. doi: 10.1016/j.jsbmb.2018.11.016. Epub 2018 Nov 30.

* Overview Asthma and Vitamin D * Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018 * Vitamin D supplements could halve risk of serious asthma attacks – Cochrane conclusion – Sept 2016 * Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015 * [Search VitaminDWiki for ASTHMA in title](https://www.google.com/search?hl=en&oe;=UTF-8&ie;=UTF-8&btnG;=Google+Search&googles.x;=0&googles.y;=0&q;=allintitle%3A+asthma&domains;=VitaminDWiki.com&sitesearch;=VitaminDWiki.com&gws;_rd=ssl) 206 items as of April 2019 * All items in Breathing and Vitamin D ** items * includes Asthma, Pneunomia, RTI, TB, Allergy, COPD * Perhaps reduce asthma exacerbations with Vitamin D – April 2019

Win SS1, Camargo CA Jr2, Khaw KT3, Lawes CMM1, Sluyter J1, Waayer D1, Toop L4, Scragg R5.

1 School of Population Health, The University of Auckland, Auckland, New Zealand.

2 Department of Emergency Medicine, and Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

3 Department of Public Health, University of Cambridge, Cambridge, United Kingdom.

4 Department of General Practice, The University of Otago, Christchurch, New Zealand.

5 School of Population Health, The U. of Auckland, Auckland, New Zealand. r.scragg@auckland.ac.nz.

BACKGROUND:

Previous studies, mostly with children, have reported inconsistent findings on the associations of vitamin D status with asthma prevalence, exacerbations, and control. Because of limited research with adults, we examined these associations in a large community-based sample of New Zealand adults.

METHODS:

5110 participants, aged 50-84 years, were recruited from the community into a clinical trial of vitamin D supplementation. The current analysis is based on baseline blood sample collection to measure serum 25-hydroxyvitamin D (25(OH)D), which was deseasonalized for data analyses; and baseline asthma assessment, which included questions on asthma prevalence, urgent medical care for asthma in the previous 12 months, and control of asthma symptoms in the previous 4 weeks.

RESULTS:

702 (13.2%) of 5088 participants reported having doctor-diagnosed asthma. There was no difference in mean (SE) 25(OH)D concentration between participants with and without asthma: 66 (0.9) and 66 (0.4) nmol/L, respectively, adjusting for sex (p = 0.71). However, in multivariable analyses restricted to participants who reported having asthma, mean (SE) 25(OH)D concentration was 6.3 (2.6) nmol/L lower in those who reported having urgent medical care for asthma in the previous 12 months compared to others (p = 0.02), and 10.4 (3.9) nmol/L lower in those with very poor asthma control compared to those who were well-controlled (p = 0.03).

CONCLUSION:

These cross-sectional results suggest that asthmatic adults with lower vitamin D status are more likely to receive urgent asthma medical care and to experience poor asthma control. Clinical trials are needed to determine the role of vitamin D supplementation in asthma management.

Tags: Breathing