An opportunity - use Vitamin D to treat Multiple Sclerosis (has been used for 14 years)
Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?
Neural Regen Res . 2022 Sep;17(9):1945-1954. doi: 10.4103/1673-5374.335139.
Sofia Fernanda Goncalves Zorzella-Pezavento 1, Luiza Ayumi Nishiyama Mimura 1, Marina Bonifácio Denadai 1, William Danilo Fernandes de Souza 1, Thais Fernanda de Campos Fraga-Silva 1, Alexandrina Sartori 1
EAE in Mice is similar to MS in humans
Multiple sclerosis is an autoimmune treatable but not curable disease. There are a multiplicity of medications for multiple sclerosis therapy, including a class entitled disease-modifying drugs that are mainly indicated to reduce the number and severity of disease relapses. Not all patients respond well to these therapies, and minor to severe adverse effects have been reported. Vitamin D, called sunshine vitamin, is being studied as a possible light at the end of the tunnel. In this review, we recapitulated the similar immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis, the immunomodulatory and neuroprotective potential of vitamin D and the state-of-art concerning its supplementation to multiple sclerosis patients. Finally, based on our and other groups' experimental findings, we analyzed the need to consider the relevance of the route and the different time-point administration aspects for a more rational indication of this vitamin to multiple sclerosis patients.
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High-Dose Vitamin D has been a part of a protocol virtually curing MS for the past 14 years
VitaminDWiki - Overview MS and vitamin D contains the following summary
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VitaminDWiki - Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol
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MS updates from Brazil
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VitaminDWiki - Is 50 ng of vitamin D too high, just right, or not enough has the following
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VitaminDWiki pages with HIGH-DOSE in title (52 items as of Feb 2022)
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