Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues

Created May 2019

Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer’s Disease: A Mendelian Randomization Study

Nutrients 2018, 10(9), 1243; https://doi.org/10.3390/nu10091243

Susanna C. Larsson 1,,Matthew Traylor 2, Hugh S. Markus 2 and Karl Michaëlsson 3

Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019
Vitamin D influences inflammation and Alzheimer’s genes (in mice) – March 2021

Information on Genes in VitaminDWiki


Gene	1. of pages
Oct 2017	Location
CYP27A1	223	Liver
CYP2R1	626	Tissue
[Vitamin D Binding Protein
GC](/tags/vitamin-d-binding-protein-gc/)	3,450	Blood
CYP27B1	803	Kidney & Tissue
Vitamin D Receptor	6,030	Cell Tissue
CYP24A1	745	excrete excess

Alzheimer's strongly associated with 2 genes and weakly associated with 5 others 1. Genetics category listing contains the following {include} --- 1. Overview Alzheimer's-Cognition and Vitamin D starts with {include} --- 1. Studies in both categories Cognition and Vitamin D Receptor {category}

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We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer’s disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables.

Data for AD were acquired from the International Genomics of Alzheimer’s Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97–1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78–0.94; p = 0.002).

This study provides evidence that vitamin D may play a role in AD but
found no significant association between S-PTH and AD.