Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis

Created November 2019

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

BMC Neurology volume 19, Article number: 284 (2019) Cite this article

Bingyan Chai, Fulin Gao, Ruipeng Wu, Tong Dong, Cheng Gu, Qiaoran Lin & Yi Zhang

Items of Cognition and Meta-analysis {category} --- Alzheimer's and Vitamin D Genes * Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018 Alzheimer's and Vitamin D Cofactors * Omega-3 index of 6 to 7 associated with best cognition in this study – Nov 2019 * Senior cognition poor if low vitamin D and low Magnesium intake – June 2019 * Dementia less likely with increased levels of Magnesium etc. --- 1. Overview Alzheimer's-Cognition and Vitamin D starts with {include}

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GrassrootsHealth plot of the data

Background

We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer’s disease(AD).

Methods

We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package.

Results

Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml).

In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10–20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml).

Conclusion

There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10–20 ng/ml).

Tags: Cognitive Meta-analysis