A year after 2nd COVID vaccination, stems cells not available to fetus immune system
Skewed Fate and Hematopoiesis of CD34+ HSPCs in Umbilical Cord Blood Amid the COVID-19 Pandemic
¡SCIENCE 2022 DOI: https://doi.org/10.1016/j.isci.2022.105544
Benjamin K. Estep, Charles J. Kuhlmann, Satoru Osuka, Gajendra W. Suryavanshi, Yoshiko Nagaoka-Kamata, Ciearria N. Samuel, Madison T. Blucas, Chloe E. Jepson, Paul A. Goepfert, Masakazu Kamata masa3k@uab.edu
1 Department of Microbiology,
Department of Pathology,
Department of Medicine and Division of Infectious Diseases, School of Medicine, University of Alabama at Birmingham, AL 35205, USA
Department of Neurosurgery, School of Medicine, University of Alabama at Birmingham, AL 35233, USA
Division of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
None left in umbilical cord a year after 2nd vaccination
Summary:
Umbilical cord blood (UCB) is an irreplaceable source for hematopoietic stem progenitor cells (HSPCs) . However, the effects of SARS-CoV-2 infection and COVID-19 vaccination on UCB phenotype, specifically the HSPCs therein, are currently unknow.
We thus evaluated any effects of SARS-CoV-2 infection and/or COVID-19 vaccination from the mother on the fate and functionalities of HSPCs in the UCB. The numbers and frequencies of HSPCs in the UCB decreased significantly in donors with previous SARS-CoV-2 infection and more so with COVID-19 vaccination via the induction of apoptosis, likely mediated by IFN-Y-dependent pathways. Two independent hematopoiesis assays, a colony forming unit assay and a mouse humanization assay, revealed skewed hematopoiesis of HSPCs obtained from donors delivered from mothers with SARS-CoV-2 infection history. These results indicate that SARS-CoV-2 infection and COVID-19 vaccination impair the functionalities and survivability of HSPCs in the UCB, which would make unprecedented concerns on the future of HSPC-based therapies.
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Discovered in Naked Emperor Substack - good description
Title = mRNA killing umbilical cord embryonic stem cells needed to repair damage and develop babies' immune systems
Hematopoietic stem cell - wikipedia
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