50,000 IU of Vitamin D weekly for 9 weeks did not improve CVD

High-dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow-up study.

Ann Clin Biochem. 2018 Mar;55(2):227-235. doi: 10.1177/0004563217707784. Epub 2017 Sep 6.

Khayyatzadeh SS1, Mirmoosavi SJ2, Fazeli M3, Abasalti Z1, Avan A3, Javandoost A1, Rahmani F1, Tayefi M3, Hanachi P4, Ferns GA5, Bahrami-Taghanaki H6, Ghayour-Mobarhan M1,3.

* Cardio parameters would havestatistically signficantly improved if they had extended the trial: to say 18+ weeks * Personal note: I have been taking 50,000 IU every 4 or 5 days for over 6 years * H Lahore, founder of VitaminDWiki 1. Overview Loading of vitamin D contains the following {include} --- * Elite Athletes do well with weekly 35,000 IU of Vitamin D – RCT Feb 2017 * * *Response to weekly 35K and 70K for 12 weeks* * * * Note: The vitamin D levels appeare to still be climbing at 12 weeks

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Background Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here, we explored the effects of high-dose vitamin D supplementation on cardio-metabolic risk factors.

Methods We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurements were obtained at baseline and after supplementation with high-dose vitamin D. All individuals took a capsule of 50,000 IU vitamin D/week for nine weeks. The study was completed by 940 participants.

Results The prevalence of vitamin D deficiency was 90% at baseline, reducing to 16.3% after vitamin D supplementation. Vitamin supplementation was associated with a significant increase in serum concentrations of 25 (OH) vitamin D and calcium. There were significant reductions in diastolic blood pressure, heart rate, waist circumference and serum fasting blood glucose, total- and low-density lipoprotein-cholesterol after the nine-week period on vitamin D treatment, but no significant effects were observed on body mass index, systolic blood pressure or serum high-density lipoprotein cholesterol and triglyceride.

Conclusion Vitamin D supplementation had beneficial effects on cardio-metabolic profile in adolescent girls.

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