3X less likely to die of COVID-19 if good level of vitamin D (seniors in Boston)

Created March 2021

Association of vitamin D status with hospital morbidity and mortality in adult hospitalized COVID-19 patients

Endocr Pract . 2021 Mar 8;S1530-891X(21)00057-4. doi: 10.1016/j.eprac.2021.02.013.

Nipith Charoenngam, MD; Arash Shirvani, MD, PhD; Niyoti Reddy, MBBS; Danica M. Vodopivec, MD; Caroline M. Apovian, MD; Michael F. Holick , MD

Highlights

  • It has been proposed that vitamin D is an immunomodulatory agent that is protective against severity of COVID-19.

  • We found an independent association between serum 25-hydroxyvitamin D ≥30 ng/mL and decreased risk of mortality from COVID-19 in elderly patients and patients without obesity.

  • It is advisable to maintain serum 25-hydroxyvitamin D at least 30 ng/mL to reduce the risk of developing severe COVID-19.

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1. COVID-19 treated by Vitamin D - studies, reports, videos {include} 1. Virus meta-analyses {category} --- 1. Also by Holick on COVID-19 include: Vitamin D, Zinc, etc. look promising for COVID-19 (Holick) – Jan 25, 2021 Call for immediate action - Fight COVID-19 with vitamin D (up to 4,000 IU) - Jan 28, 2021 Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020 * image

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Objective

To determine the association between vitamin D status and morbidity and mortality in adult hospitalized COVID-19 patients

Methods

We performed a retrospective chart review study in COVID-19 patients aged ≥18 years old hospitalized at Boston University Medical Center between March 1 – August 4, 2020. All studied patients were tested positive for COVID-19 and had serum levels of 25-hydroxyvitamin D results measured within one year prior to the date of positive tests. Medical information was retrieved from the electronic medical record and were analyzed to determine the association between vitamin D status and hospital morbidity and mortality.

Results

Among the 287 patients, 100 (36%) patients were vitamin D-sufficient [25(OH)D >30 ng/mL] and 41 (14%) patients died during the hospitalization. Multivariate analysis in patients aged ≥65 years old revealed that

  • vitamin D sufficiency [25(OH)D ≥30 ng/mL] was statistically significantly associated

    • with decreased odds of death (adjusted OR 0.33 , 95%CI, 0.12–0.94),

  • acute respiratory distress syndrome (adjusted OR 0.22 , 95%CI, 0.05–0.96), and

  • severe sepsis/septic shock (adjusted OR 0.26 , 95%CI, 0.08–0.88),

after adjustement for potential confounders.

Among patients with body mass index <30 kg/m 2, vitamin D sufficiency was statistically significantly associated with a decreased odds of death (adjusted OR 0.18 , 95%CI, 0.04–0.84). No significant association was found in the subgroups of patients aged <65 years old or BMI ≥30 kg/m 2.

Conclusion

We revealed an independent association between vitamin D sufficiency defined by serum 25(OH)D ≥30 ng/mL and decreased risk of mortality from COVID-19 in elderly patients and patients without obesity.

Tags: Virus