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Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012

Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis

Journal of Pharmacology and Pharmacotherapeutics , 2012 , Volume 3, Issue 4,Page 300-303
Jaykaran Charan1, Jagdish P Goyal2, Deepak Saxena3, Preeti Yadav1
1 Department of Pharmacology, Govt. Medical College, Rajkot, India
2 Department of Pharmacology, P. D. U. Govt. Medical College, Rajkot, India
3 Department of Epidemiology, Indian Institute of Public Health, Ahmedabad, Gujarat, India
Date of Web Publication 24-Nov-2012
Correspondence Address: Jaykaran Charan, Department of Pharmacology, Govt. Medical College, Surat, Gujarat, India

Objectives : To explore the effect of vitamin D supplementation in prevention of respiratory tract infections on the basis of published clinical trials.

Materials and Methods : Clinical trials were searched from various electronic databases. Five clinical trials were suitable for inclusion. Outcome was events of respiratory tract infections in vitamin D group and placebo group. Data was reported as odds ratio with 95% confidence interval. Both random and fixed model was used for analysis. Analysis was done with the help of Comprehensive meta-analysis software 2.

Results : Events of respiratory tract infections were significantly lower in vitamin D group as compared to control group [Odds ratio = 0.582 (0.417 - 0.812) P = 0.001] according to random model. Results were similar in fixed model. On separate analysis of clinical trials dealing with groups of children and adults, beneficial effect of vitamin D was observed in both, according to fixed model [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.653 (0.472 - 0.9040, P = 0.010 respectively]. On using random model beneficial effect persisted in children's group but became nonsignificant in adults group [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.544 (0.278 - 1.063) P = 0.075 respectively].

Conclusion : Vitamin D supplementation decreases the events related to respiratory tract infections. There is need of more well conducted clinical trials to reach to a certain conclusion.

How to cite this article:
Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother 2012;3:300-3

How to cite this URL:
Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother [serial online] 2012 [cited 2012 Nov 27];3:300-3. Available http://www.jpharmacol.com/text.asp?2012/3/4/300/103685
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Note that only vitamin D monotherapy was considered, thus ignoring trials using cofactors

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PDF is attached at the bottom of this page

See also VitaminDWiki

See also web (another analysis)

Attached files

ID Name Comment Uploaded Size Downloads
1750 Respire Fig 1 PRISMA.jpg admin 27 Nov, 2012 45.41 Kb 1655
1749 Respiratory tract review Dec 2012.pdf admin 27 Nov, 2012 698.54 Kb 1115