The effects of vitamin D plus calcium supplementation on metabolic profiles, biomarkers of inflammation, oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia
Journal of Human Nutrition and Dietetics, Article first published online: 14 OCT 2015, DOI: 10.1111/jhn.12339
M. Samimi1, M. Kashi1, F. Foroozanfard1, M. Karamali2, F. Bahmani3, Z. Asemi3,*, Y. Hamidian4, H. R. Talari4 and A. Esmaillzadeh 5,6
The present study was designed to examine the effects of vitamin D plus calcium administration on metabolic profiles and pregnancy outcomes among women at risk for pre-eclampsia.
In a prospective, double-blind, placebo-controlled trial, 60 women at risk for pre-eclampsia were randomised to take either 50 000 IU vitamin D3 every 2 weeks plus 1000 mg day−1 calcium supplements (as calcium carbonate) (n = 30) or to receive placebos at the same times (n = 30) from 20 to 32 weeks of gestation. Fasting blood samples were taken at baseline and 12 weeks after intervention to determine related variables. Newborn anthropometric measurements were determined.
Taking combined cholecalciferol and calcium supplements, compared to placebo, led to significant reductions in
- fasting plasma glucose (FPG) [mean (SD)] [−5.7 (5.5) versus −0.6 (12.6) mg dL−1, P = 0.04],
- serum insulin concentrations [−2.8 (6.0) versus +7.7 (9.8) μIU mL−1, P < 0.001],
- homeostasis model of assessment-insulin resistance [−0.8 (1.3) versus +1.6 (2.2), P < 0.001],
- homeostatic model assessment-beta cell function [−8.2 (25.8) versus +32.6 (41.3, P < 0.001]
- and a significant rise in quantitative insulin sensitivity check index score [+0.02 (0.02) versus −0.02 (0.02, P < 0.001].
Additionally, pregnant women who received cholecalciferol plus calcium supplements had
- increased serum high-density lipoprotein (HDL)-cholesterol [+4.6 (8.3) versus −2.9 (7.7) mg dL−1, P = 0.001] and
&plasma total glutathione (GSH) concentrations [+23.4 (124.0) versus −94.8 (130.2) μm, P = 0.001] compared to placebo.
However, after adjustment for the baseline levels, maternal age and baseline body mass index, the effects on FPG levels (P = 0.13) and systolic blood pressure (P = 0.13) disappeared.
Vitamin D plus calcium administration for 12 weeks had beneficial effects on glycaemic status, HDL-cholesterol, GSH and blood pressure among women at risk for pre-eclampsia.
See also VitaminDWiki
Pages listed in BOTH the categories Pregnancy and Hypertension (preeclampsia)
- Pre-eclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017
- Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017
- Child 49 percent higher risk of being overweight if hypertension during pregnancy – Sept 2017
- Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017
- Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
- Pre-eclampsia is not reduced by vitamin D (if you ignore vitamin D level, dose size, frequency and duration) – July 2017
- Preeclampsia doubles the risk of mild cognitive impairment – July 2017
- No Hypertension during pregnancy if more than 60 ng of vitamin D – RCT
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Preclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Preeclampsia 4X less likely if vitamin D levels increased by 8 ng during pregnancy – March 2016
- Pre-eclampsia 2X more likely if low vitamin D, unless adjust for vitamin D factors (BMI, skin color) – Dec 2015
- Preeclampsia and eclampsia associated with lower vitamin D, etc. – Sept 2015
- Preeclampsia increased risk of Congenital Heart Defects by 60 percent (vitamin D not mentioned) Oct 2015
- Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
- Burkas reduce vitamin D levels, which causes pregnancy problems – Oct 2015
- Preeclampsia – hypothesis as to why vitamin D helps – June 2015
- Pre-eclampsia inversely proportional to serum Magnesium – Oct 2014
- Hypertension in pregnancy (preeclampsia) more frequent in winter (low vitamin D) – Jan 2015
- Pre-eclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014
- Preeclampsia 40 percent less likely if mother had more than 20 ng of vitamin D – Jan 2014
- Pre-Eclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013
- During pregnancy even 400 IU helps metabolic status – RCT July 2013
- 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013
- 7X increase in early severe preeclampsia associated with low vitamin D – Aug 2012
- Pre-eclampsia 3X more likely if low vitamin D at 25th week – April 2012
- Low vitamin D results in severe preeclampsia and low birth weight – Mar 2011
- Women with low vitamin D 4X more likely to have preeclampsia in pregnancy – Nov 2010
- Seasonal variation in pregnancy hypertension is correlated with sunlight intensity -June 2010 no abstract