Time-release form of active vitamin D granted a patent for chronic kidney disease – July 2014

OPKO Granted Patent from US Patent & Trademark Office for RAYALDEE

• Treat secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency.
• US Pat. No. 8,778,373

Notes by VitaminDWiki

1. Standard vitamin D is not available to much of the body when the kidney is not working
2. Standard active vitamin D has a very short half life, so time release form should be an excellent improvement - see other options below

See also VitaminDWiki

• Calcitriol category listing has 56 items along with related searches
• Vitamin D3 vs serum D3 (Calcitriol, HyD) – Jan 2012
• Vitamin D3 becomes Calcidiol which becomes Calcitriol
• Nano-encapsulated of Vitamin D3, Calcidiol, calcitriol look promising, esp time release – Dec 2012 7 day!!
• Overview Kidney and vitamin D
• Getting Vitamin D into your body
• Modified release active Vitamin D (calcifediol ) for those with poor Kidney function (USD 10,000 per year) – April 2015

See also web

• Modified-Release Calcifediol Corrects Vitamin D Deficiency, Secondary Hyperparathyroidism in Chronic Kidney Disease Nov 2014
  They found Modified-Release Calcifediol did much better than a placebo. Apparently did not test it against Vitamin D
• Modified-release oral calcifediol corrects vitamin D insufficiency with minimal CYP24A1 upregulation Nov 2014
   Download the PDF from VitaminDWiki.
  One of many charts in the PDF