Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017

Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis

European Neuropsychopharmacology, online 5 October 2017
Cora Schefft a, Laura L.Kilarski b. Tom Bschor c, Stephan Köhler
https://doi.org/10.1016/j.euroneuro.2017.07.004

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Vitamin D and Omega-3 have decreased a lot recent decades

Zinc and Vitamin D category has 88 items

20 Most-visited pages in Depression category in VitaminDWiki

Id Page Hits Last modification Creator Categories
7681 Depression 97457
25 Mar, 2024 13:53
admin Depression
Category
Associations
5777 Suicide associated with low vitamin D - many studies 43531
26 Oct, 2023 15:23
admin Depression
6247 ALL of the top 10 health problems of women are associated with low vitamin D 35677
01 Dec, 2022 21:39
admin Cardiovascular
Diabetes
Health
Cancer - Breast
Depression
Top news
Cognitive
Stroke
Women
3315 Hypothesis: Some Mental Illness could be treated or prevented with vitamin D 33065
29 Jan, 2021 19:56
admin Depression
Treatment by Vitamin D
Top news
537 Prisoners have very low vitamin D and get TB, influenza, and depression 22454
11 Nov, 2019 18:39
admin Deficiency of Vitamin D
Tuberculosis
Depression
Shut-in
Virus
5764 Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013 21453
14 Jun, 2016 02:26
admin Depression
Intervention
14357 Only Vitamin D was found to treat post-partum depression - Meta-analysis April 2023 21385
03 Feb, 2024 13:25
admin Pregnancy
Depression
7450 MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 20515
08 Jan, 2023 14:03
admin Bone - Health
Breathing
Pregnancy
Diabetes
Depression
Vitamin D and Magnesium
Parkinson
Cystic Fibrosis
Hypertension
Stroke
4658 First episode psychosis associated with a 33 percent lower vitamin D in 3 races – Sept 2013 18396
09 Dec, 2017 16:17
admin Depression
7196 Seasonal Affective Disorder treatments include vitamin D and bright light – review Dec 2015 18221
11 Feb, 2024 21:07
admin Depression
5252 Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014 17296
30 Apr, 2021 03:23
admin Depression
Meta-analysis of Vitamin D
Top news
5082 Children with mental disorders have somewhat less vitamin D levels (graph) Jan 2014 16481
23 Feb, 2014 12:45
admin Depression
Cognitive
1052 Hypothesis - Reduce insomnia with vitamin D 15963
13 Oct, 2010 21:55
admin Depression
4757 Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013 15927
18 Sep, 2017 17:15
admin Depression
Intervention
Top news
Injection
4028 Fewest Google searches for Mental Health when there is lots of vitamin D from the sun – May 2013 15767
29 Apr, 2013 20:21
admin Depression
Top news
Cognitive
3608 Suicide 2X more likely with low vitamin D (in military) – Jan 2013 14127
15 Aug, 2015 15:50
admin Depression
6789 Omega-3 prevents PTSD and some mood disorders - Aug 2015 13793
14 Sep, 2019 16:09
admin Depression
Vitamin D and Omega-3
5274 Tricyclic antidepressants reduce the active but not the normally measured form of vitamin D in seniors – April 2014 13588
16 Oct, 2022 22:27
admin Depression
Top news
4187 99 percent of psychiatric population had less than 30 ng of vitamin D – June 2013 12915
08 May, 2018 12:12
admin Depression
5075 Serotonin regulated by Vitamin D – part 1 autism – Feb 2014 12862
21 Mar, 2022 14:27
admin Depression
Autism
Sleep
Vitamin D and Omega-3

Pages listed in BOTH the categories Depression and Omega-3


In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc.

A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment (“add-on” OR "adjunctive" OR "augmentation"). Meta-analyses, randomized controlled trials (RCTs) and non-randomized comparative studies that investigated the supplements as an add-on in the treatment of clinically diagnosed MDD were included. Agents had to be added to an existing antidepressant regime (augmentation) or started simultaneously with the antidepressant (acceleration). For n-3 PUFAs, folic acid and zinc, new meta-analyses were performed as part of this work.
Our meta-analyses of 10 articles on n-3 PUFAs and four on zinc support their efficacy. For folic acid, our meta-analysis does not support efficacy. For n-3 PUFAs, sensitivity analysis showed no difference between acceleration and augmentation designs, but significant differences between individuals with or without comorbidities. For the remaining substances, only a few RCTs were available. The preliminary data on inositol was negative, while one RCT for vitamin D demonstrated positive results. For vitamin B12 one and for SAMe two RCTs and a few open trials are available reporting positive and mixed results. To summarize, for most of the substances, the available data is not yet sufficient or inconclusive.

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