Ischemic stroke 17 X more likely if low vitamin D – April 2017


Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome.

Metab Brain Dis. 2017 Apr;32(2):493-502. doi: 10.1007/s11011-016-9939-2
Alfieri DF1, Lehmann MF2, Oliveira SR1, Flauzino T1, Delongui F1, de Araújo MC3, Dichi I4, Delfino VD4, Mezzaroba L5, Simão AN5, Reiche EM6.

Modified Rankin Scale (mRS) three-months later

Image

The aim of this study was to investigate whether vitamin D deficiency (VDD) is associated with acute ischemic stroke, inflammatory markers, and short-term outcome. 168 acute ischemic stroke patients and 118 controls were included. The modified Rankin Scale (mRS) was applied up to 8 h of admission (baseline) and after three-months follow-up, and blood samples were obtained up to 24 h of admission to evaluate serum levels of 25-hydroxivitamin D [25(OH)D] and inflammatory markers. Vitamin D levels classified the individuals in sufficient (VDS ≥ 30.0 ng/mL), insufficient (VDI 20.0-29.9 ng/mL), and deficient (VDD < 20.0 ng/mL) status.

Patients had lower levels of 25(OH)D, higher frequency of VDD (43.45% vs. 5.08%, OR: 16.64, 95% CI: 5.66-42.92, p < 0.001), and higher inflammatory markers than controls (p < 0.05).

Patients with VDD showed increased high sensitivity C-reactive protein (hsCRP) levels than those with VDS status (p = 0.043); those with poor outcome presented with lower 25(OH)D levels than those with good outcome (p = 0.008); moreover, 25(OH)D levels were negatively correlated with mRS after three-months follow-up (r = -0.239, p = 0.005). The associations between VDD and higher hsCRP levels and between 25(OH)D levels and poor outcome at short-term in acute ischemic stroke patients suggest the important role of vitamin D in the inflammatory response and pathophysiology of this ischemic event.
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VitaminDWiki – Stroke category contains

122 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke


Stroke Meta-analysis


23+ VitaminDWiki Stroke pages have ISCHEMIC OR ISCHAEMIC in the title

This list is automatically updated

Items found: 23
Title Modified
Ischemic Stroke is 18% more likely if poor Vitamin D genes (unless take more Vitamin D) – Feb 2024 21 Mar, 2024
High Omega-3 reduced risk of Ischemic stroke by 18% - Dec 2023 05 Jan, 2024
Elderly vaccinated for COVID were 2X more likely to die of ischemic stroke (2930 vs 1180 deaths)– Nov 2021 22 Nov, 2021
Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016 05 Mar, 2021
Poor Ischemic stroke outcome (END) 2.6 X worse if low vitamin D – March 2019 26 Nov, 2019
Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019 02 May, 2019
Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018 29 Jun, 2018
Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis Feb 2018 28 Feb, 2018
Ischaemic Stroke has less impact in animals supplemented with Omega-3 – Jan 2018 13 Feb, 2018
Vitamin D levels drop after ischemic stroke – Dec 2017 20 Jan, 2018
Ischemic stroke 17 X more likely if low vitamin D – April 2017 13 Jan, 2018
Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017 04 Jan, 2018
Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017 27 Oct, 2017
Ischemic stroke and low vitamin D – 3X higher risk of poor outcome, 6 X higher risk of a second stroke, Oct 2017 04 Oct, 2017
Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017 01 Aug, 2017
Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017 01 Aug, 2017
Risk of Ischemic Stroke doubles if take more than 1 gram of Calcium daily for years – May 2017 20 May, 2017
Ischemic Stroke risk best predicted by Vitamin D, including PTH improves the prediction – Feb 2017 02 Mar, 2017
Ischemic Stroke with low vitamin D resulted in larger lesions – May 2015 11 Mar, 2016
Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012 12 Jul, 2015
Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014 29 Dec, 2014
Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014 17 Dec, 2014
Acute ischemic stroke 19 percent more likely if even lower vitamin D – Sept 2013 14 Sep, 2013

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