Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade.
Int J Cancer. 2011 Oct 27. doi: 10.1002/ijc.27327.
Gilbert R, Metcalfe C, Fraser WD, Donovan J, Hamdy F, Neal DE, Athene Lane J, Martin RM.
School of Social and Community Medicine, University of Bristol. Becky.Gilbert@bristol.ac.uk.
Epidemiological studies suggest that vitamin D protects against prostate cancer, although evidence is limited and inconsistent. We investigated associations of circulating total 25-hydroxyvitamin D OH)D) with PSA-detected prostate cancer in a case-control study nested within the Prostate Testing for Cancer and Treatment (ProtecT) trial. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) quantifying the association between circulating total 25(OH)D and prostate cancer. In case-only analyses, we used unconditional logistic regression to quantify associations of total 25(OH)D with stage (advanced vs localized) and Gleason grade (high-grade (?7) vs low-grade (<7. Pre-determined categories of total 25(OH)D were defined as: high: ?30ng/mL; adequate: 20-<30ng/mL; insufficient: 12-<20ng/mL; deficient: <12ng/mL. Fractional polynomials were used to investigate the existence of any U-shaped relationship. We included 1,447 prostate cancer cases (153 advanced, 469 high-grade) and 1,449 healthy controls.
There was evidence that men deficient in vitamin D had a two-fold increased risk of advanced versus localized cancer (OR for deficient vs adequate total 25(OH)D=2.33, 95% CI: 1.26,4.28) and high-grade versus low-grade cancer (OR for deficient vs adequate total 25(OH)D=1.78, 95% CI: 1.15,2.77).
There was no evidence of a linear association between total 25(OH)D and prostate cancer (p=0.44) or of an increased risk of prostate cancer with high and low vitamin D levels.
Our study provides evidence that lower 25(OH)D concentrations were associated with more aggressive cancers (advanced versus localized cancers and high- versus low- Gleason grade), but there was no evidence of an association with overall prostate cancer risk.
Copyright © 2011 UICC.
PMID: 22033893
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See also VitaminDWiki
- All items inn Prostate Cancer and Vitamin D 31 items March 2012
- Epigenetics of prostate cancer and vitamin D – June 2010
- 16 percent less Prostate Cancer sometimes for each 10ng vitamin D increase - Jan 2011
- 59 percent more likely to die of Prostate Cancer if very low on vitamin D – April 2011