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Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017

Magnesium Intake, Quality of Carbohydrates, and Risk of Type 2 Diabetes: Results From Three U.S. Cohorts

Diabetes Care 2017 Oct; dc171143. https://doi.org/10.2337/dc17-1143
Adela Hruby, Marta Guasch-Ferré, Shilpa N. Bhupathiraju, JoAnn E. Manson, Walter C. Willett, Nicola M. McKeown and Frank B. Hu


OBJECTIVE Magnesium intake is inversely associated with risk of type 2 diabetes in many observational studies, but few have assessed this association in the context of the carbohydrate quality of the diet. We hypothesized that higher magnesium intake is associated with lower risk of type 2 diabetes, especially in the context of a poor-carbohydrate-quality diet characterized by low cereal fiber or high glycemic index (GI) or glycemic load (GL).

RESEARCH DESIGN AND METHODS In the

  • Nurses’ Health Study (NHS; 1984–2012, n = 69,176),
  • NHS2 (1991–2013, n = 91,471), and the
  • Health Professionals’ Follow-Up Study (1986–2012, n = 42,096),

dietary intake was assessed from food frequency questionnaires every 4 years. Type 2 diabetes was ascertained by biennial and supplementary questionnaires. We calculated multivariate hazard ratios (HRs) of magnesium intake and incident diabetes, adjusted for age, BMI, family history of diabetes, physical activity, smoking, hypertension, hypercholesterolemia, GL, energy intake, alcohol, cereal fiber, polyunsaturated fats, trans fatty acids, and processed meat, and we considered the joint associations of magnesium and carbohydrate quality on diabetes risk.

RESULTS We documented 17,130 incident cases of type 2 diabetes over 28 years of follow-up. In pooled analyses across the three cohorts, those with the highest magnesium intake had 15% lower risk of type 2 diabetes compared with those with the lowest intake (pooled multivariate HR in quintile 5 vs. 1: 0.85 [95% CI 0.80–0.91], P < 0.0001). Higher magnesium intake was more strongly associated with lower risk of type 2 diabetes among participants with high GI or low cereal fiber than among those with low GI or high cereal fiber (both P interaction <0.001).

CONCLUSIONS Higher magnesium intake is associated with lower risk of type 2 diabetes, especially in the context of lower-carbohydrate-quality diets.

Publisher wants $35 for the PDF

  The free PDF from SciHub has the following

  • “For example, in those with low cereal fiber intake, risk of diabetes in those with high magnesium intake compared with low intake was 0.84 (95% CI 0.79–0.91), representing a difference in relative risk of 16%. In those with high cereal fiber intake, risk of diabetes in those with low magnesium intake was 0.82 (95% CI 0.76–0.90), whereas risk in those with high magnesium intake was 0.71 (95% CI 0.67–0.75), representing a difference in relative risk of 11%.”


Created by admin. Last Modification: Sunday October 8, 2017 13:50:11 UTC by admin. (Version 7)

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