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Iron in blood decreases with vitamin D in males, increases with premenopausal females (Korea)– May 2017

Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults

PLoS One. 2017 May 31;12(5):e0177722. doi: 10.1371/journal.pone.0177722. eCollection 2017.
Seong JM1, Yoon YS2,3, Lee KS2, Bae NY4, Gi MY5, Yoon H6.

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Diseases associated with

Low iron (menstruating) High iron (males)
Anemia Anemia of chronic disease
Fibromyalgia Premature aging
Inflammatory bowel disease Atherosclerosis
Hypothyroidism Anorexia
Depression / anxiety Grave's disease
Attention deficit hyperactivity disorder Heart arrhythmia
Parkinson's disease Cancer
Neurodegenerative conditions Sideroblastic anemia
Celiac disease Nonalcoholic fatty liver disease (NAFLD).
Excess dietary fructose is a primary initiator of NAFLD,
but high iron is another culprit that triggers disease progression
Restless leg syndrome Liver damage and liver disease
Hair loss Still's disease
Muscle weakness, decline in motor skills Hemochromatosis
Mental changes and memory loss Hemophagocytic syndrome


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BACKGROUND:
The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults.

METHODS:
A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL).

RESULTS:
The key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456).

CONCLUSION:
Serum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women.

PMID: 28562685 PMCID: PMC5451000 DOI: 10.1371/journal.pone.0177722

Created by admin. Last Modification: Friday September 22, 2017 12:11:02 UTC by admin. (Version 6)

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