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300,000 IU Vitamin D injection before brain tumor surgery – RCT to finish Dec 2017

Clinical Trial Entry: Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery


RCT expected to finish Dec 2017 - publication probably will be 2019-2021
Not clear when the vitamin D injection will be given – hopefully >3 days before the surgery
60 patients – including the 30 controls who will not get any Vitamin D


VitaminDWiki

Expects that there will be very few RCT’s like this in the future.
It will become morally wrong to not give Vitamin D to all surgery, ICU, etc. patients

Overview Loading of vitamin D contains the following

If a person is, or is suspected to be, very vitamin D deficient a loading dose is typically given

  • Loading = repletion = quick replacement (previously known as Stoss)
  • Loading doses range in size from 100,000 IU to 1,000,000 IU of Vitamin D3
  • The size of the loading dose is a function of body weight - see below
    Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day, to as slowly as 3 months.
    It appears that spreading the loading dose over 4-20 days is a good compromise
  • Loading is typically oral, but sometimes by injection (I.M,)
  • The loading dose persists in the body for about 3 months
    The loading dose should be followed up with continuing maintenance
    Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • As about 1 in 300 people have some form of mild allergic reaction to vitamin D supplements,
    it appears prudent to test with a small amount of vitamin D before giving a loading dose
  • The causes of a mild allergic reaction appear to be: (in order of occurance)
    1) lack of magnesium - which can be easily added
    2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )

Injection category contains the following

31 items in Vitamin D Injection category

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  • Injections are currently made by medical professionals into muscle
  • Home injection of Vitamin D appears to be possible in the future
  • Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
  • While Vitamin D2 is historically the common form, Vitamin D3 is far better
  • Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
  • Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
  • 100,000 IU single dose of vitamin D - 2010 has the following
    Image
  • Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
    Image
Created by admin. Last Modification: Friday December 29, 2017 13:29:01 UTC by admin. (Version 5)
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