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Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017

Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis.

Oncotarget. 2017 Jun 29. doi: 10.18632/oncotarget.18888. [Epub ahead of print]
Zhang X1, Huang XZ1, Chen WJ1, Wu J1, Chen Y2, Wu CC1, Wang ZN3.

VitaminDWiki Summary

21% reduction in deaths, but no reduction in occurrence (study on this page)

That is, high Vitamin D blood level does not change who gets pancreatic caner, but it does increase survival

Note: Like many other diseases, how much vitamin D actually gets to the cells is far more important that how much is in blood

See also VitaminDWiki

Vitamin D Receptor category has the following

198 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 40 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor

Genetics category listing contains the following

207 articles in Genetics the category

 

see also 198 articles in Vitamin D Receptor, 82 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 37+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are poor
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Additional information on the Genes in VitaminDWiki

Gene# of pages
Oct 2017
Location
CYP27A1223 Liver
CYP2R1 626Tissue
Vitamin D Binding Protein 3,450 Blood
CYP27B1803Kidney & Tissue
Vitamin D Receptor 6,030Cell Tissue
CYP24A1 745 excrete excess


 Download the PDF from VitaminDWiki

Pancreatic cancer MORTALITY

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Pancreatic cancer INCIDENCE

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BACKGROUND:
The associations between vitamin D status, including plasma 25-hydroxyvitamin D [25(OH)D] levels and vitamin D intake, and pancreatic cancer risk and mortality are inconsistent. The aims of this study are to evaluate the antitumor and therapeutic effects of vitamin D status for pancreatic cancer patients.

METHODS:
A literature search for relevant studies was conducted using PubMed and Embase databases. Risk ratio (RR), hazard ratio (HR), and 95% confidence interval (CI) were used as the effect measures. All statistical analyses were performed using Stata software 12.0.

ESULTS:
Our results indicated that high plasma 25(OH)D levels were inversely associated with pancreatic cancer mortality without significant heterogeneity (HR=0.81, 95% CI=0.68-0.96). However, high plasma 25(OH)D levels could not reduce pancreatic cancer risk (RR=1.02, 95% CI=0.66-1.57). Moreover, vitamin D intake was also not associated with pancreatic cancer risk (RR=1.11, 95% CI=0.67-1.86)

Conclusions: Our results indicate that high plasma 25(OH)D levels were significantly associated with improved survival in pancreatic cancer patients. However, there were no significant associations between vitamin D intake or plasma 25(OH)D levels and pancreatic cancer risk.

PMID: 28733547 DOI: 10.18632/oncotarget.18888

Created by admin. Last Modification: Wednesday November 22, 2017 03:16:35 UTC by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
8209 PC risk.jpg admin 25 Jul, 2017 15:27 41.87 Kb 175
8208 PC mortality.jpg admin 25 Jul, 2017 15:27 38.21 Kb 140
8207 pancreatic cancer mortality.pdf PDF 2017 admin 25 Jul, 2017 15:26 1.81 Mb 49
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