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Vitiligo (loss of skin pigment) treated by narrowband UVB – July 2014

Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy

ISRN Dermatology, Volume 2014 (2014), Article ID 493213, 6 pages, http://dx.doi.org/10.1155/2014/493213
Manu Sehrawat,1 Tarlok Chand Arora,1 Amrita Chauhan,1 Hemanta Kumar Kar,1 Amitabh Poonia,2 and Vijayeeta Jairath2
1PGIMER, Dr. RML Hospital, New Delhi, India
2Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana 124001, India

Cholecalciferol (vitamin D) might play a physiological role in photo-induced melanogenesis in human skin. We estimated the levels of 25-hydroxy vitamin D [25(OH)D] before, during, and after Narrow Band Ultraviolet B (NBUVB) radiation in patients of vitiligo and their correlation with NBUVB induced pigmentation. Thirty patients of vitiligo and equal number of age and sex matched controls were recruited for the study. Vitiligo patients were treated with NBUVB thrice weekly for 12 weeks. [25(OH)D] levels and Vitiligo Area and Severity Index (VASI) were calculated at 0 (baseline), 6, and 12 weeks. Baseline [25(OH)D] levels were measured in controls. Significant reduction in VASI score was observed after 12 weeks of therapy. Comparison and correlation between mean improvement in VASI and [25(OH)D] levels at 12 weeks showed moderate correlation, and the results were statistically insignificant. Mean reduction in VASI and increase in [25(OH)D] levels after 12 weeks of NBUVB showed moderate correlation. Thus, vitamin D might play a significant role in photo-induced melanogenesis. However, there might be additional effects of the phototherapy on melanogenesis. The complete mechanism of NBUVB induced pigmentation in vitiligo needs to be elucidated.

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A 2nd article in July 2014

Narrowband ultraviolet B phototherapy in combination with other therapies for vitiligo: mechanisms and efficacies.
J Eur Acad Dermatol Venereol. 2014 Jul 30. doi: 10.1111/jdv.12619. [Epub ahead of print]
Yazdani Abyaneh M1, Griffith RD, Falto-Aizpurua L, Nouri K.
1Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.

Vitiligo is a disorder of pigmentation affecting about 1% of the global population. It is a psychologically devastating disease with suboptimal treatment options. Narrowband ultraviolet B (NB-UVB) phototherapy has become a first-line choice for treating generalized disease. In recent years, topical calcineurin inhibitors, vitamin D analogues, antioxidant agents and other therapies have been combined with NB-UVB to improve its efficacy. This article will address what is known about the mechanisms of action of these treatments and how they may complement NB-UVB on a cellular level, as well as offer a comprehensive, evidence-based review of clinical outcomes with combination therapies.

© 2014 European Academy of Dermatology and Venereology.
Publisher provides low-cost access to the PDF
PMID: 25073648

See also VitaminDWiki

Two out of 16 vitiligo patients showed no repigmentation of the affected areas;
four patients showed 1–25% repigmentation,
five patients showed 26–50% repigmentation,
five patients showed 51–75% repigmentation and
none showed more than 75% repigmentation of the affected areas

See also web

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Attached files

ID Name Comment Uploaded Size Downloads
4135 V3.jpg admin 10 Jul, 2014 12:53 45.66 Kb 1609
4134 V2.jpg admin 10 Jul, 2014 12:53 41.94 Kb 1580
4133 V1.jpg admin 10 Jul, 2014 12:52 34.50 Kb 4731
4132 Vitiligo T6.jpg admin 10 Jul, 2014 12:52 43.40 Kb 2374
4131 Vitiligo F3.jpg admin 10 Jul, 2014 12:51 40.17 Kb 2079
4130 Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients.pdf PDF 2014 admin 10 Jul, 2014 12:51 2.74 Mb 442
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