UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet.
Int J Cancer. 2014 May 29. doi: 10.1002/ijc.29002. Epub ahead of print
Rebel H1, der Spek CD, Salvatori D, van Leeuwen JP, Robanus-Maandag EC, de Gruijl FR.
Mortality from colorectal cancer increases with latitude and decreases with ambient UV radiation. We investigated whether moderate UV dosages could inhibit intestinal tumor development and whether this corresponded with UV-induced vitamin D. FabplCre;Apc15lox/+ mice, which develop intestinal tumors, and their parents were put on a vitamin D-deficient diet. Next to a control group, one group was vitamin D supplemented and another one group was daily UV irradiated from 6 weeks of age. Vitamin D statuses after 6 weeks of treatment were markedly increased: mean ± SD from 7.7 ± 1.9 in controls to 75 ± 15 nmol/l with vitamin D supplementation (no gender difference), and to 31 ± 13 nmol/l in males and 85 ± 17 nmol/l in females upon UV irradiation. The tumor load (area covered by tumors) at 7.5 months of age was significantly reduced in both the vitamin D-supplemented group (130 ± 25 mm2 , p = 0.018) and the UV-exposed group (88 ± 9 mm2 , p < 0.0005; no gender differences) compared to the control group (202 ± 23 mm2 ). No reductions in tumor numbers were found. Only UV exposure appeared to reduce progression to malignancy (p = 0.014). Our experiments clearly demonstrate for the first time an inhibitory effect of moderate UV exposure on outgrowth and malignant progression of primary intestinal tumors, which at least in part can be attributed to vitamin D.
Summary by VitaminDWiki
|Mice||Vitamin D||Cancer area||Reduce |
|No vitamin D in diet, no UVB||3 ng||202 mm2||No|
|Vitamin D in diet||30 ng||130 mm2||No|
|UVB – males||12 ng||88 mm2||Yes|
|UVB – females||34 ng||88 mm2||Yes|
This confirms previous hints that UVB (such as from sunlight) produces more than just Vitamin D
See also VitaminDWiki
- Cancer Council of Australia recommends 30 minutes of daily sunshine – June 2014
- A review of the evidence regarding the solar ultraviolet-B-vitamin D-cancer hypothesis - Oct 2012
- Cancer incidence in 87 countries is related to food, smoking, alcohol, GDP, and UVB - Jan 2014
- Some childhood cancer 30% less likely in parts of California with more UVB – April 2013
- Solar UVB reduces Cancer Risk – Grant, Jan 2013
- More UVB is associated with less cancer – study of 450,000 people – April 2012
- 2200X more problem from no UVB than too much UVB - WHO 2006
- Benefits of sun are more than vitamin D – 2008
- Vitamin D from low-cost UVB lamps
- Hypothesis: Sun provides more than vitamin D – June 2012
- Beneficial effects of UV radiation other than via vitamin D production – June 2012
- Mouse MS: UVB but not Vitamin D reduced incidence - April 2010