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Autistic children have lower levels of Iron, Vitamin D, Magnesium, etc – Oct 2017

Iron and vitamin D levels among autism spectrum disorders children

Ann Afr Med, 2017 Vol 16, Issue : 4, age : 186-191, online 16-Oct-2017, DOI: 10.4103/aam.aam_17_17


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Abdulbari Bener1, Azhar O Khattab2, Dinesh Bhugra3, Georg F Hoffmann4

  • 1 Department of Biostatistics and Medical Informatics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, England, UK
  • 2 Department of Pediatrics, Rumailah and Hamad General Hospital, Hamad Medical Corporation; Department of Pediatrics, Weill Cornell Medical College, Ar-Rayyan, Qatar
  • 3 Institute of Psychiatry, Section of Cultural Psychiatry, King's College London, London, England, UK
  • 4 Department of Pediatrics, University of Heidelberg, Baden-Wurttemberg, Germany

Aim: The aim of this study was to investigate iron deficiency anemia and Vitamin D deficiency among autism children and to assess the importance of risk factors (determinants).

Subjects and Methods: This was a case–control study conducted among children suffering from autism at the Hamad Medical Corporation in Qatar. A total of 308 cases and equal number of controls were enrolled. The Autism Diagnostic Observation Schedule-Generic was the instrument used for diagnosis of Autism.

Results: The mean age (±standard deviation, in years) for autistic versus control children was 5.39 ± 1.66 versus 5.62 ± 1.81, respectively. The mean value of serum iron levels in autistic children was severely reduced and significantly lower than in control children (74.13 ± 21.61 μg/dL with a median 74 in autistic children 87.59 ± 23.36 μg/dL in controls) (P = 0.003). Similarly, the study revealed that Vitamin D deficiency was considerably more common among autistic children (18.79 ± 8.35 ng/mL) as compared to healthy children (22.18 ± 9.00 ng/mL) (P = 0.004).
Finally, mean values of

  • hemoglobin,
  • ferritin,
  • magnesium;
  • potassium,
  • calcium;
  • phosphorous;
  • glucose,
  • alkaline phosphate,
  • hematocrit,
  • white blood cell, and
  • mean corpuscular volume

were all statistically significantly higher (better?) in healthy control children as compared to autistic children (P < 0.001).
Multivariate logistic regression analysis revealed that serum iron deficiency, serum calcium levels, serum Vitamin D levels; ferritin, reduced physical activity; child order, body mass index percentiles, and parental consanguinity can all be considered strong predictors and major factors associated with autism spectrum disorders.

Conclusion: This study suggests that deficiency of iron and Vitamin D as well as anemia were more common in autistic compared to control children.

Created by admin. Last Modification: Saturday October 21, 2017 12:25:01 UTC by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
8573 Autism T3.jpg admin 21 Oct, 2017 12:10 42.61 Kb 76
8572 Autism T2.jpg admin 21 Oct, 2017 12:09 67.91 Kb 81
8571 Austic children low Iron, Vit d, Mg,etc.pdf admin 21 Oct, 2017 12:07 165.59 Kb 82
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