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60,000 IU vitamin D weekly with daily Calcium was safe but not enough in the winter – 2012

Efficacy and Safety of Cholecalciferol Supplementation in Vitamin D Deficient Subjects Based on Endocrine Society Clinical Practice Guidelines


Endocrinol Metabol Syndrome 2012, S:4 http://dx.doi.org/10.4172/2161-1017.S4-004
Chittari Venkata Harinarayan1*, Leena Appicatlaa2, Bangalore Arunachalam Nalini3 and Shalini Joshi3
1Chief Consultant Endocrinologist, Fortis Hospitals (opp IIM-B), Bannerughatta Road, Bangalore - 560 076, India 2Chief Biochemistry Services, Fortis Hospitals (opp IIM-B), Bannerughatta Road, Bangalore - 560 076, India 'Consultant Internal Medicine, Fortis Hospitals (opp IIM-B), Bannerughatta Road, Bangalore - 560 076, India
•Corresponding author: Prof C.V.Harinarayan, Fortis Hospitals (opp IIM-B), Bannerughatta Road, Bangalore - 560 076, India, E-mail: cvhari5endo at rediffmail.com
Received January 09, 2012; Accepted February 13, 2012; Published February 15, 2012

Background: Hypovitaminosis is widely prevalent in India with limited data on vitamin D supplementation regimens.

Objective: We studied the efficacy and safety of vitamin D supplementation as per the Endocrine Society Clinical Practice Guidelines (ESCPG) in vitamin D-deficient subjects.

Design: Fifty-two healthy subjects had their serum albumin, creatinine, calcium, alkaline phosphatase, 25 OH vitamin D (25OH D), and intact PTH estimated at baseline, two and five months of supplementation. They were supplemented with Cholecalciferol 9572 IU/day and elemental calcium 1 gm/day. At the end of the 2nd month, those who attained vitamin D sufficiency were supplemented with Cholecalciferol 3000 IU/day, and those who still did not attain vitamin D sufficiency with Cholecalciferol 5286 IU/day along with 1 gm elemental calcium and the latter were reassessed after three months.

Results: The mean ± SD of serum calcium, phosphorous, and alkaline phosphatase were in the normal range at baseline, 2 and 5 months of supplementation (P= NS). The baseline median (IQR-Interquartile range) of 25 OHD and PTH was 6 (4-11) ng/ml and 19.6 (33-62) pg/ml respectively. In 2nd month there was a threefold increase in 25 OHD levels 19.6 (14.6-28.75) ng/ml and a further 50% increase in 5th month of supplementation. PTH levels were suppressed by 38 % at 2nd month and remained stable at 5th month. At the end of the 5th month, 46% had attained vitamin D sufficiency, and 27% of subjects were still vitamin D insufficient.

Conclusions: Vitamin D supplementation based on recent ESCPG, even up to upper tolerable intake levels (UL), along with elemental calcium of 1gm/day, is safe and does not lead to hypercalcemia.

Introduction

Vitamin D is synthesized in adequate amounts on casual exposure of skin to sunlight to a radiation waveband of 290 - 315 nm in most humans [1,2]. The UVB photons are absorbed by the epidermal 7-dehydrocholesterol e(7-DHC) (provitamin D), which is rapidly converted to cholecalciferol (previtamin D3) by a temperature-dependent process. This previtamin D3 enters into the circulation bound to vitamin D binding protein (DBP). Previtamin D3 is converted into 25 hydroxy vitamin D (25 OH D) in the liver, which is biologically inert and requires hydroxylation in the kidney on carbon 1 by the enzyme 1 hydroxylase. The biologically active form of vitamin D is responsible for regulation of calcium and phosphate metabolism and is essential for maintaining bone health from infant to adult health. Vitamin D2 is from dietary sources. Vitamin D2 and D3 (D represents D2 and D3) are fat-soluble vitamins incorporated into chylomicrons and absorbed into the lymphatics. Serum 25 OH D levels are a reliable indicator of the vitamin D status of an individual. The optimal level of 25OH D to maintain skeletal health and maximal dietary absorption of calcium in the gut is accepted to be 30 ng/ml and is defined as vitamin D sufficiency [36]. A value of <20 ng/ml is defined as vitamin D deficiency and values between 20 to 30 ng/ml are defined as vitamin D insufficiency.
The Indian subcontinent is situated between latitudes 37.6°N and 8.4°N, with plentiful sunlight throughout the year. Despite this fact, several studies from India have documented the widespread prevalence of hypovitaminosis D across the length and breadth of the country in all age groups [7]. Studies in South India have shown that rural agricultural laborers' who have their torsos exposed to sunlight for more than 5-6 hours during their agricultural profession also have hypovitaminosis D of varying degrees [8,9]. Increased urbanization, avoidance of sunlight, clothing practices, and greater atmospheric pollution may aggravate this problem [10]. While severe vitamin D deficiency may present with radiological features of rickets/osteomalacia, subclinical vitamin D deficiency or insufficiency may have adverse consequences on the bone because of secondary hyperparathyroidism. Adequate supplementation with vitamin D may increase bone mass and decrease the risk of fractures [11,12].
The optimal amount of vitamin D required for the treatment of vitamin D has been a matter of debate until the recent publication of Endocrine Society Clinical Practice Guidelines (ESCPG) [13]. The ESCPG suggests that all adults who are vitamin D deficient be treated with 50,000 IU of vitamin D2 or vitamin D3 once a week for 8 weeks or its equivalent of6000 IU of vitamin D2 or vitamin D3 daily to achieve a blood level of 25(OH) D above 30 ng/ml, followed by maintenance therapy of 1500-2000 IU/day. The upper tolerable limit of 10,000 IU/day for children and adults 19 yr and older may be needed to correct vitamin D deficiency. In India, one study used 60,000 IU of Cholecalciferol once a month (2000 IU/day) and later 120,000 IU per month (4000 IU/day) for three months without calcium supplementation [14]. This study concluded that monthly administration of 60,000 IU of cholecalciferol in healthy subjects with hypovitaminosis D may be sufficient in summer months, but higher doses are required in winter months to maintain 25(OH) D levels in the normal range. Another study has used 60,000 IU/week along with oral calcium supplementation 1 gram per day which also contains Cholecalciferol 500 IU/day (totaling a dose of Cholecalciferol of 8642 IU/day) for a period of eight weeks [15]. Though this study has shown a loading dose of vitamin D raises the 25OH D levels to the normal range, the effect is not sustained over a period of one year [15]. The recent clinical practice guidelines by the endocrine society [13] give us guidance to treat "Vitamin D deficiency" and the amount of supplementation dose required to maintain adequate vitamin D levels. We report our experience in a group of subjects with vitamin D deficiency treated based on recent endocrine society guidelines.

Materials and Methods

Fifty-two consecutive subjects were recruited for the study. Most of them were asymptomatic volunteers, attenders of patients who accompanied them for other illnesses. None of them had clinical signs or symptoms of overt metabolic bone disease, such as bone pains, myopathy, or fractures.
Exclusion criteria included a history of renal, liver, and dermatological diseases, known cases of hypocalcemia or hyperparathyroidism, pregnant and lactating women, history of drug ingestion (steroids, antiepileptic drugs, and rifampicin), and those with vitamin D intoxication and granulomatous diseases.
Study design and conduct
The study was conducted from July to November 2011. All patients were given cholecalciferol supplementation administered orally 60,000 IU (1500 ug) (Calcirol, Cadila Pharmaceuticals) per week [equivalent to Cholecalciferol 8,572 IU/day; (214 ug/day)] along with supplementation of calcium tablets twice a day [each tablet contains 1,250 mg of calcium carbonate equivalent to elemental calcium of 500 mg along with Cholecalciferol 500 IU (12.5 |ig)] ("Shelcal - HD" Elder pharmaceuticals) for eight weeks. In total, these patients received Cholecalciferol of 9572 IU/day (239 uig/day) [8572 from the sachets (calculated from the weekly dosage of Cholecalciferol) and 1000 IU/ day via the calcium tablets along with 1 gm of elemental calcium] as "supplementation therapy" (Figure 1). The tolerable upper intake level (UL) of Cholecalciferol given by Endocrine Society Clinical Practice Guidelines is 10,000 IU/ day for adults who are vitamin D deficient for a period of eight weeks [13].

Follow-up, compliance, and subjects analyzed

After two months of therapy, they were evaluated again for their vitamin D status and other biochemical parameters. Those who had achieved "vitamin D sufficiency (25 OH vitamin D levels >30 ng/ml)" were treated with cholecalciferol supplementation administered orally 60,000 IU once a month (equivalent to 2,000 IU/day - as suggested by the guidelines as a maintenance dose to maintain the 25 OH vitamin D levels above 30 ng/ml) along with supplementation of calcium tablets twice a day. Hence in total, these patients received Cholecalciferol of 3,000 IU/day [2,000 IU from the sachets and 1,000 IU via calcium tablet supplementation along with 1 gm of elemental calcium per day).
In subjects whose 25 OHD levels did not reach a vitamin D sufficiency range, they were supplemented again with Cholecalciferol. They were given Cholecalciferol supplementation administered orally 60,000 IU per fortnight (equivalent to Cholecalciferol 4,286 IU/day) along with supplementation of calcium tablets twice a day. Hence in total, these patients received Cholecalciferol of 5,286 IU/day (132.5 ug/ day) [[4,286 IU from the sachets (calculated from the weekly dosage of Cholecalciferol given once in a fortnight) and 1000 IU/ day via the calcium tablets] along with 1 gm of elemental calcium. After three months of therapy, they were reassessed for their vitamin D status and other biochemical parameters. The second dose of supplementation was half the initial dose so that the patients may not go into hypercalcemia with prolonged therapy (Figure 1). All subjects have stressed the need for regularity and compliance with supplementation in the study period to achieve normal 25(OH) D levels.

Biochemical estimations

After overnight fast venous blood samples were collected in the fasting state without applying a tourniquet for estimation of baseline biochemical and hormonal parameters; quantitative estimation of serum creatinine, albumin, calcium, phosphorous and alkaline phosphatase was determined by an automated analyzer (Roche cobas c 501), using kits supplied by of Roche cobas. Serum albumin was estimated by BCG green (normal range 3.5 to 5.2 g/dl) (detectable limit: 0.2-6g/dl); serum creatinine by Jaffe, generation 2 (normal 0.5 -1.2 mg/dl),(detectable limit: 0.17 -24.9 mg/dl); serum calcium by O-cresol phthalein complex one,(normal range 8.4 -10.2 mg/dl), (detectable limit: 0.4 to 20 mg/dl); serum phosphorous by UV Molybdate method (normal range 2.7 -4.5 mg/dl; (detectable limit 0.31 to 20 mg/dl), serum alkaline phosphatase by IFCC Gen 2 (normal range Men: 40 -130 IU/L; Women: 35-105 IU/L), (detectable limit: 5-1200 IU/L). Electrochemiluminescence ECLIA estimated Serum Vitamin D3 on Elecsys 2010. The assay employs a polyclonal antibody directed against 25-OH vitamin D3. It is a competitive assay. (Traceability: The method has been standardized against LC-MS-MS) (Detectable range: 4-100 ng/ml). A value of 30 ng/ml is defined as vitamin D sufficiency. A value of < 20 ng/ml is defined as vitamin D deficiency, and values between 20 to 30 ng/ml are defined as vitamin D insufficiency. Parathyroid Hormone (PTH) intact was estimated by electrochemiluminescence ECLIA on Elecsys 2010 Roche cobas kit. (Normal range is 15-65 pg/ml), (detectable range 1.2 to 5000 pg/ml.
Figure 1:

Statistical analysis

Statistical analysis was performed with the statistical software SPSS (Version 11.5). Results are expressed as mean ± standard error of the mean (SEM). Group means at different intervals of time of supplementation were compared using parametric (paired students t-test) tests. ANOVA, followed by the Bonferroni correction test, was used to compare various indices at three different intervals. With respect to 25 OHD and intact PTH variables, the wide dispersion median and interquartile range (IQR) is calculated. For these two parameters to compare the changes in therapy with different intervals of time, a non-parametric test (Wilcoxon-signed ranks sign test) was used. P value of <0.05 was considered significant.

Results

The mean age of the study group was 48 ± 15 years (17 men and 35 women). The baseline biochemical and hormonal parameters are shown in Table 1.
All 52 subjects recruited for the study returned for follow-up at the end of two months of vitamin D supplementation therapy. The results at the end of 2nd and 5th month of supplementation were as follows (Figure 2):

  • 1) Twenty-three percent (23%) of subjects (n=12) had 25 OH D levels in the vitamin D sufficiency range. These subjects were given maintenance therapy as outlined. At the end of three months of maintenance therapy, they did not return for follow-up. All of them were individually contacted over the telephone and requested for review. These subjects claimed their well-being was good and were not inclined to reevaluate again.
  • 2) Twenty-three percent (23%) of subjects (n=12) had 25 OHD levels in the vitamin D in the insufficiency range. They were given a second course of supplementation as outlined above, to be reviewed after 3 months (Figure 2). Fifty percent of the subjects (n=6) returned for 2nd review at the end of 5th month (i.e., after 3 months of 2nd supplementation). All of them had their 25 OHD levels in the vitamin D sufficiency range. The remaining six of them were lost in follow-up.
  • 3) Fifty-four percent of the subjects (n=28) had 25 OHD levels in the vitamin D deficiency range (25 OHD levels < 20 ng/ml). This group of patients was given 2nd course of supplementation for three months and reviewed. At the end of three months, 22% (n=6) of subjects achieved vitamin D sufficiency; 29% (n=8) of subjects were still vitamin D insufficient; 22% (n=6) of subjects were vitamin D deficient, and 8 subjects were lost on follow up (Figure 2 and Table 2).


Table 1: Biochemical Parameters of the study group at Baseline, 2nd and 5th month of cholecalciferol supplementation.
Table 2: Biochemical characterization of the study group based on subjects who responded at initial supplementation of cholecalciferol at the end of 2nd month and their follow-up till 5th month.

All subjects had normal serum albumin, creatinine, calcium, phosphorous and alkaline phosphatase at baseline before initiation of supplementation. The median and IQR (in brackets) of 25 OH D and intact PTH levels were 6 (4-11) ng/ml and 46 (33 - 62) pg/ml fell to 28.7 (22.5-36) pg/ml, which was statistically significant (P <0.001). The 25 OH D and intact PTH correlated negatively (r = - 0.28; P < 0.05). The 25 OH D levels were elevated three times compared to baseline in the 2nd month and by 50% at the 5th month of supplementation (compared to the 2nd month), which was statistically significant (P<0.001). The intact PTH levels were suppressed by 38% from the baseline in the 2nd month, which was statistically significant P<0.001). With follow-up, there was no significant suppression of PTH levels in the 5th month of supplementation (Figure 3).
There was no statistically significant difference in other biochemical parameters such as serum albumin, creatinine, calcium, phosphorous and alkaline phosphatase between baselines, 2nd and 5th months of supplementation.

Discussion

Following the increased awareness of widespread vitamin D deficiency in India [7] there has been much debate regarding corrective measures and adequate intake of vitamin D to correct vitamin D deficiency state. In India, apart from vitamin D deficiency, dietary calcium deficiency co-exists. Adequate levels of 25 OH D are required for maximal absorption of calcium from the gut [3,4].
The present study is based on the current Endocrine Society Clinical Practice Guideline [13]. Previous studies from India have used either 3000 or4000 IU/day of Cholecalciferol without calcium supplementation [14,16] or 8642 IU/day of Cholecalciferol supplementation along with 1 gm of elemental calcium [15]. There is no mention of those who did not respond to therapy and their further follow-up. This study addresses these issues. The present study has emphasized "supplementation therapy" for achieving vitamin D sufficiency and later "maintenance therapy" to be followed as a preventive strategy for keeping bone health based on guideline recommendations [14]. The present study also addresses the nonresponder's follow-up.
In the present study, only 23% of subjects attained vitamin D sufficiency at the end of 2 months of supplementation with a threefold rise in serum 25OH D levels. We used 9572 IU/day of Cholecalciferol which is the near-upper tolerable intake level (UL) as per the guidelines [13]. In our study, 23% of subjects attained vitamin D sufficiency as compared to 54% of subjects who attained normalcy in other studies from India [15], which used similar dosage schedules. The probable reason could be that the present study was conducted beginning in July, and the supplementation schedule followed through winter till December. In the other study in India [15], the patients were recruited in March and followed through summer till May/June.
Increased sunlight exposure could be the possible explanation for these differences. This explanation is substantiated by another study from India in the same location [14], which showed 2000 IU/day (50 ug/day) of Cholecalciferol provided different incremental responses in serum 25 OH D levels of a group of patients supplemented in summer and winter. The incremental response of 25 OH D was higher in summer compared to winter [14].
There is no documented study from this country on the follow-up of subjects who did not respond to initial 2 months of "supplementation therapy" (on supplementing with Cholecalciferol along with calcium). In the present study, only 23% of subjects attained vitamin D sufficiency at the end of 2 months of supplementation. Of the remaining 77% who did not achieve vitamin D sufficiency, 23% were in the vitamin D insufficiency range and 54 % in the vitamin D deficiency range at the end of 2 months of supplementation. We used half the UL of Cholecalciferol recommended by the guidelines keeping in view the patient shouldn't go into hypercalcemia during 3 months of second supplementation (Figure 2).
At the end of five months of supplementation, 46% of the recruited subjects (n=52) had achieved vitamin D sufficiency, and 27 % were still in the vitamin D insufficiency range. None of them presented with hypercalcemia despite the dose of Cholecalciferol in the UL of the recommendation, along with elemental calcium supplementation of 1 gm per day. About 27% of subjects were still vitamin D deficient at the end of 5th month of vitamin D supplementation. We postulate that these subjects should be evaluated for malabsorption of the gut. Other studies from India have also shown that only 56% to 47% of their study group had attained a sufficient vitamin D range [14,15]. The other group used 25 OH D levels of 20 ng/ml as their normal range and hence could not be compared [16]. The intact PTH levels dropped by 38% from the baseline and were stable in the 5th month of therapy (Figure 3).
The potential implications of vitamin D deficiency in Indians are wide-ranging. Apart from the low bone mass, it might involve an association with type 2 diabetes mellitus and pulmonary tuberculosis. From the results of the present study, the following conclusions can be drawn.

  • 1) calcium supplementation should form an integral part of therapy for the treatment of hypovitaminosis D,
  • 2) Vitamin D used in the upper ceiling dose of 10,000 IU/day, as recommended by the Endocrine Society clinical practice guidelines, does not produce hypercalcemia
    (despite elemental calcium supplementation of 1g/day) as observed in this study and other studies [17,18] also,
  • 3) Evaluation of vitamin D status may be required at the end of 2 months of (Figure 4) supplementation to assess the need for further supplementation or maintenance therapy as a part of the preventive strategy,
  • 4) patients with vitamin D insufficiency at baseline may reach vitamin D sufficiency after 2 months of supplementation, and
  • 5) Patient with severe vitamin D deficiency at baseline (25 OH D <4ng/ml, which is also the lowest detectable limit of the assay
    - hence we may not be aware of the actual deficiency) may require a 2nd supplementation therapy (the dose and duration needs to be ascertained by further studies) (Figure 4).

There are limitations in the study with respect to the number of subjects studied and the duration of the study. In a country like India, financial constraints are to screen, evaluate and follow up (mainly the cost of investigation and medicines). More studies with larger numbers from different parts of India might help arrive at a consensus, especially with respect to the duration of therapy and the need for second supplementation for non-responders. Still, this short duration study of five to six months gives us an idea of supplementations and problems one is likely to face in supplementation of vitamin D in a country like India.
Acknowledgment
CVH designed the study, followed up with the patients, did an analysis of data, and was involved in writing the manuscript. LA did the laboratory analysis and was involved in writing the manuscript; BAN and SJ co ordinated the follow-up of the patients and interacted with them. There is no conflict of interest among the authors.

References

  • 1. Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3: Exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 67: 373-378.
  • 2. Holick MF (2011) Vitamin D: a d-lightful solution for health. J Investig Med 59: 872-880.
  • 3. Heaney RP, Dowell MS, Hale CA, Bendich A (2003) Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 22: 142-146.
  • 4. Heaney RP (2003) Vitamin D depletion and effective calcium absorption. J Bone Miner Res 18:1342.
  • 5. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357: 266-281.
  • 6. Fuleihan GE, Deeb M (1999) Hypovitaminosis D in a sunny country. N Engl J Med 340: 1840- 1841.
  • 7. Harinarayan CV, Joshi SR (2009) Vitamin D status in India - its implications and remedial measures. J Assoc Physicians India 57: 40-48.
  • 8. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D (2008) Vitamin D status in Andhra Pradesh: a population-based study. Indian J Med Res 127: 211-218.
  • 9. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D, Srinivasarao PV, et al. (2007) High prevalence of low dietary calcium, high phytate consumption and vitamin D deficiency in healthy south Indians. Am J Clin Nutr 85: 10621067.
  • 10. Babu US, Calvo MS (2010) Modern India and the vitamin D dilemma: evidence for the need for a national food fortification program. Mol Nutr Food Res 54:1134-1147.
  • 11. Harinarayan CV, Alok S, Amaresh RP, Satish KM, Prasad UV, et al. (2011) Vitamin D Status and Bone Mineral Density in Women of Reproductive and Postmenopausal Age Groups: A Cross-Sectional Study from South India. J Assoc Physicians India 59: 698-704.
  • 12. Harinarayan CV (2005) Prevalence of vitamin D insufficiency in postmenopausal south Indian women. Osteoporos Int 16: 397-402.
  • 13. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96: 19111930.
  • 14. Malhotra N, Mithal A, Gupta S, Shukla M, Godbole M (2009) Effect of vitamin D supplementation on bone health parameters of healthy young Indian women. Arch Osteoporos 4: 47-53.
  • 15. Goswami R, Gupta N, Ray D, Singh N, Tomar N (2008) Pattern of 25-hydroxy vitamin D response at short (2 months) and long (1 year) intervals after 8 weeks of oral supplementation with cholecalciferol in Asian Indians with chronic hypovitaminosis D. Br J Nutr 100: 526-529.
  • 16. Marwaha RK, Tandon N, Agarwal N, Puri S, Agarwal R, et al. (2010) Impact of two regimens of vitamin D supplementation on calcium - vitamin D - PTH axis of schoolgirls of Delhi. Indian Pediatr 47: 761-769.
  • 17. Vieth R, Chan PC, MacFarlane GD (2001) Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 73: 288-294.
  • 18. Vieth R (1999) Vitamin D supplementation, 25- hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69: 842-856

PDF is attached at the bottom of this page

VitaminDWiki suspects that this study failed to wait weeks after dosing before taking testing the vitamin D serum levels.
The serum levels take at least 3 days to rise after a big dose.
Dose ==> Response example in the following chart
see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=1046


See also VitaminDWiki

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=3057


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Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021 23 Feb, 2021
Weekly 50,000 IU was the most succesful way to restore vitamin D levels (football) - Aug 2020 09 Feb, 2021
Endometriosis treated by Vitamin D (50,000 IU bi-weekly) – RCT Jan 2021 30 Jan, 2021
Bone density improved by monthly 50,000 IU of vitamin D for 6 months – RCT Jan 2021 20 Jan, 2021
Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015 14 Jan, 2021
Take 50,000 IU of Vitamin D weekly before and after COVID-19 vaccination 27 Dec, 2020
Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015 27 Dec, 2020
Trial: Can 50,000 IU of Vitamin D weekly help with Breast Cancer Chemotherapy - Early 2021 22 Dec, 2020
A call to action: Vitamin D for hip fracture (50,000 weekly for 8 weeks, then bi-weekly – Holick July 2020 12 Dec, 2020
50,000 IU vitamin D weekly to avoid Osteroporosis after Breast Cancer - May 2020 26 Nov, 2020
BPH (PSA) decreased by Vitamin D (50,000 IU bi-weekly) – RCT Nov 2020 21 Nov, 2020
60,000 IU dose of VItamin D (weekly, monthly) is popular in India 18 Nov, 2020
In Vitro Fertilization clinical trial using 50,000 IU of Vitamin D bi-weekly – Dec 2024 14 Sep, 2020
Only 1 NCAA basketball player getting 10,000 IU vitamin D daily achieved 50 ng goal – Jan 2020 01 Sep, 2020
Sperm not improved enough by Vitamin D - 50,000 IU weekly for 8 weeks - RCT Aug 2020 27 Aug, 2020
Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016 25 Jul, 2020
Weekly 50,000 IU of vitamin D is again found to be good – RCT May 2020 27 May, 2020
COVID-19 might be prevented in 2 months by 50,000 IU weekly – May 12, 2020 12 May, 2020
Reduce Coronavirus risk with Vitamin D (50,000 IU once a week) 27 Mar, 2020
IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020 25 Mar, 2020
50,000 IU Vitamin D weekly provided enough benefit for combat sport athletes – March 2020 21 Mar, 2020
Response by obese to weekly 50,000 IU of Vitamin D – May 2018 12 Feb, 2020
Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019 18 Jan, 2020
Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023 16 Jan, 2020
Low Vitamin D symptoms, need 50-80 ng, he takes 5,000 IU – Matthews interview Dec 2019 30 Dec, 2019
Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs 25 Dec, 2019
Obese taking 50,000 IU of vitamin D weekly lost more weight (again) – RCT Dec 2019 25 Dec, 2019
General Anxiety Disorder treated by weekly Vitamin D (50,000 IU -Omega-3, Mg also help) – Sept 2019 09 Dec, 2019
Cystic Fibrosis not helped by 50,000 IU of Vitamin D taken twice a month – RCT Feb 2019 02 Nov, 2019
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 20 Oct, 2019
PMS again significantly reduced by 50,000 IU of vitamin D (This time, every two weeks) – RCT Oct 2019 19 Oct, 2019
Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019 17 Oct, 2019
Long-term neck and back pains greatly reduced by 50,000 IU of Vitamin D – 4 cases – Sept 2019 14 Sep, 2019
Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019 10 Sep, 2019
Preeclampsia 2.7 X less likely if 50,000 IU of Vitamin D every 2 weeks – meta-analysis Sept 2019 06 Sep, 2019
Severely Obese not helped much by 50,000 IU of vitamin D weekly for 8 weeks – RCT June 2019 22 Aug, 2019
Athletes helped by weekly 50,000 IU Vitamin D – RCT Aug 2019 10 Aug, 2019
Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019 02 Aug, 2019
Vitamin D less costly if give 100,000 IU monthly (but 50,000 IU biweekly should save more money) – July 2019 17 Jul, 2019
Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT Dec 2018 07 Jul, 2019
Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014 01 Jul, 2019
Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019 01 Jul, 2019
Treating Vitamin D deficiency in senior women – such as 50,000 IU daily for 15 days then twice a month – Review April 2019 14 Jun, 2019
Methadone cognition improved by 50,000 IU of vitamin D every 2 weeks – RCT May 2019 14 Jun, 2019
Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019 09 May, 2019
PMS in teens reduced 3X by 50,000 IU vitamin D weekly – Jan 2018 23 Mar, 2019
Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019 22 Feb, 2019
Poor Vitamin D binding had 30 percent less response to Vitamin D (50,000 IU weekly) – Feb 2019 04 Feb, 2019
Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018 12 Jan, 2019
Sleep improved with 50,000 IU Vitamin D every two weeks – RCT Oct 2018 20 Dec, 2018
Depression probably treated by bi-weekly 50,000 IU of vitamin D - RCT 2020 06 Dec, 2018
50,000 IU of vitamin D weekly following cardiac failure helps – RCT 2014 24 Nov, 2018
Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018 21 Nov, 2018
Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019 17 Nov, 2018
Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017 03 Nov, 2018
Depression in seniors treated by weekly 50,000 IU of vitamin D – RCT Sept 2018 15 Oct, 2018
50,000 IU of Vitamin D weekly for 9 weeks did not improve CVD – Aug 2018 28 Aug, 2018
Multiple Sclerosis and Vitamin D ~ 50,000 Facebook members in 13 languages – Jan 2017 23 Aug, 2018
Osteoporosis in men increased their risk of Dementia by 1.3 (60,000 Germans) – July 2018 21 Aug, 2018
Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018 07 Jul, 2018
Asthma treated by daily 50,000 IU of Vitamin D – April 2018 25 Jun, 2018
Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 23 Jun, 2018
Vitamin D - at least 4,000 IU to achieve 40-60 ng and reduce risk of early death – Holick June 2018 04 Jun, 2018
Pancreatic Cancer stabilized by a woman taking 50,000 IU of vitamin D daily - 2016 04 Jun, 2018
Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018 28 May, 2018
Concussion which caused unconsciousness increased risk of Parkinson's by 50 percent (300,000 military) - May 2018 07 May, 2018
Knee pain and depression reduced by monthly 50,000 IU vitamin D – RCT April 2018 21 Apr, 2018
50,000 IU vitamin D routinely given monthly in New Zealand senior homes since 2011– Dec 2016 07 Apr, 2018
IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016 14 Mar, 2018
Pain not relieved by monthly 100,000 IU of vitamin D (need 50,000 IU weekly) – RCT Feb 2018 02 Mar, 2018
HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017 01 Mar, 2018
Common cause of dizziness (BPPV) treated by several doses of 50,000 IU of vitamin D – 2015, 2016 12 Feb, 2018
Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – 2015, 2016 12 Feb, 2018
Cystic Fibrosis got some benefit from 50,000 IU of vitamin D weekly (need gut-friendly form) – Feb 2018 04 Feb, 2018
Sleep disorders treated with 50,000 IU Vitamin D every 2 weeks – RCT May 2017 07 Dec, 2017
Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017 18 Nov, 2017
Vitamin D taken daily (4,000 IU) vs weekly (50,000 IU) – RCT 2019 23 Oct, 2017
Vitamin D supplementation for newborns – 400 IU daily vs 50,000 IU dose – RCT Sept 2016 21 Oct, 2017
Dry eye decreased with weekly 50,000 IU vitamin D injection for 8 weeks – Sept 2017 07 Sep, 2017
Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017 01 Sep, 2017
Sleep quality improved with 50,000 IU of vitamin D every two weeks – RCT May 2017 23 Aug, 2017
Preeclampsia reoccurred half as often if get 50,000 IU of Vitamin D every two weeks – Aug 2017 22 Aug, 2017
Vitamin D supplementation guidelines (adults – 50,000 IU per week) – Feb 2017 21 Aug, 2017
Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017 28 Jul, 2017
Canadian grant funding lost for prescribing 50,000 IU of vitamin D – July 2017 24 Jul, 2017
Cervical lesions (precancerous, identified by pap smear) treated by bi-weekly 50,000 IU of vitamin D – RCT Feb 2017 22 Jul, 2017
Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014 20 Jul, 2017
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 20 Jul, 2017
50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013 20 Jul, 2017
Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017 18 Jul, 2017
Chinese women in tropics needed 50,000 IU of Vitamin D monthly to keep above 30 ng – RCT May 2017 14 Jul, 2017
50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017 08 Jul, 2017
Fertility marker (Anti-Müllerian Hormone) improved in a week by a single dose to 50,000 IU of vitamin D – RCT July 2017 08 Jul, 2017
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – Nov 2016 27 Jun, 2017
Many benefits of 50,000 IU vitamin D every two weeks (methadone treatment) – RCT June 2017 21 Jun, 2017
Don’t take a PRESCRIPTION of 50,000 IU of vitamin D – June 2017 05 Jun, 2017
Vitamin D – 50,000 IU monthly is enough if near the equator and have normal weight – May 2017 25 Apr, 2017
50,000 IU of vitamin D weekly (D3 or D2) got two thirds of cystic fibrosis patients to 30 nanograms – RCT July 2015 23 Apr, 2017
Single dose (up to 60,000 IU) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT March 2013 05 Apr, 2017
Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015 15 Mar, 2017
50,000 IU vitamin D weekly is safe and effective for Primary Hyperparathyroidism – Jan 2013 23 Jan, 2017
Pulmonary hypertension reduced in some people with weekly 50,000 IU vitamin D for 3 months – 2016 16 Jan, 2017
Chronic Back Pain relieved by weekly 60,000 IU of vitamin D – Jan 2017 10 Jan, 2017
50,000 IU of vitamin D for 8 weeks of pregnancy raised most above 30 nanograms - RCT Jan 2017 29 Dec, 2016
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 25 Dec, 2016
Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015 24 Nov, 2016
Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT Dec 2013 06 Oct, 2016
Chikungunya virus arthritis pain reduced by weekly 60,000 IU vitamin D – Sept 2016 29 Sep, 2016
Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016 03 Sep, 2016
Vitamin D trial – 60,000 IU monthly to reduce death and colon cancer – results due 2025 12 Aug, 2016
5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015 06 Aug, 2016
Free Vitamin D in New Zealand to prevent falls in nursing homes (50,000 IU monthly) – June 2016 30 Jul, 2016
Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014 13 Jul, 2016
A group of 6,000 people have vitamin D levels higher than 50 ng – GrassrootsHealth 29 Jun, 2016
50,000 IU vitamin D daily in ICU greatly reduces number and cost of heart attacks – Nov 2015 25 Jun, 2016
Nursing home residents need Vitamin D 4,000 IU daily or 50,000 IU weekly – Jan 2016 25 May, 2016
Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – April 2013 23 May, 2016
Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013 23 May, 2016
IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016 17 May, 2016
Monthly 60,000 IU of Vitamin D did not reduce mortality (too infrequent)- Feb 2022monthly) will reduce mortality – results due 2024 19 Apr, 2016
Prediabetics not helped by 50,000 IU of vitamin D weekly and Calcium– Jan 2013 03 Apr, 2016
New Zealand – new 50,000 IU vitamin D capsule has soy which can cause allergic reactions – March 2016 09 Mar, 2016
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 09 Mar, 2016
50,000 IU of dry vitamin D needed at least daily following obesity surgery – forum Jan 2016 17 Feb, 2016
Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015 23 Oct, 2015
Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient – Oct 2015 16 Oct, 2015
Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015 15 Oct, 2015
Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 02 Oct, 2015
Vitamin D is very important during pregnancy – 4,000 daily or 50,000 weekly - review Jan 2015 02 Oct, 2015
Vitamin D more than 40 ng: 1300 IU 50% chance: 5,000 IU 80% chance - Aug 2014 14 Sep, 2015
Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015 10 Sep, 2015
Hives treatment augmented by 60,000 IU Vitamin D weekly – RCT June 2015 22 Aug, 2015
Vitamin D levels of HIV and non HIV equally restored with 50,000 IU twice a week - July 2015 24 Jul, 2015
Diabetes not treated by MONTHLY 50,000 IU vitamin D (which is not quite enough) – May 2015 12 Jul, 2015
Diabetes RCT we expect to fail just 50,000 IU monthly - July 2014 12 Jul, 2015
No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015 21 Jun, 2015
Near the end of pregnancy 50,000 IU vitamin D weekly was great – RCT April 2013 08 Jun, 2015
Vitamin D video: calcification, narrow-band UV, 4,000 IU, 50 ng – Dr. DeLuca May 2015 04 Jun, 2015
Vitamin D toxicity after 50,000 IU daily for 2 years (no surprise) – April 2015 26 Apr, 2015
Pregnant mothers in Quatar needed more than weekly 50,000 IU Vitamin D – Nov 2013 29 Mar, 2015
Peripheral Neuropathy in type II Diabetes reduced a bit by 50,000 IU weekly of vitamin D – RCT Feb 2015 28 Mar, 2015
Lupus not treated by monthly 50,000 IU vitamin D (no surprise) – RCT April 2015 23 Mar, 2015
Pregnancy helped by single dose of 60,000 IU of Vitamin D – RCT March 2015 15 Mar, 2015
50,000 IU Vitamin D one time after birth helped – RCT Jan 2015 14 Jan, 2015
50,000 IU monthly safe to take without any vitamin D testing – RCT Dec 2013 22 Dec, 2014
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 23 Nov, 2014
Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery – Oct 2014 24 Oct, 2014
Diabetes treated by 50,000 IU of vitamin D weekly with 1 g Calcium daily – RCT July 2014 14 Sep, 2014
Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013 14 Sep, 2014
Vitamin D levels of seniors restored with 50,000 IU weekly for 8 weeks – April 2014 01 Sep, 2014
7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012 21 Aug, 2014
Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014 03 Aug, 2014
Vitamin D repaired nerve in rat (50,000 IU daily dose equivalent for human) – June 2013 28 Jun, 2014
Gestational Diabetes mostly treated with just 2 doses of 50,000 IU of vitamin D – RCT Dec 2013 26 Jun, 2014
Death rate 2X higher at age 60 if low vitamin D - 180,000 in Israel May 2012 13 Jun, 2014
Optic neuritis progession into Multiple Sclerosis reduced 68 percent by 50,000 IU of vitamin D weekly 08 May, 2014
COPD helped by weekly 50,000 IU Vitamin D – Aug 2013 03 May, 2014
Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014 10 Apr, 2014
7100 IU vitamin D (50,000 weekly) significantly reduced fibromyalgia – 2009 20 Jan, 2014
Need to adjust cofactors if take 50,000 IU of vitamin D weekly – Nov 2013 12 Jan, 2014
50,000 IU of vitamin D monthly in winter gets most above 20 ng – RCT Nov 2013 22 Dec, 2013
50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013 13 Nov, 2013
At least 5,000 IU Vitamin D to get to optimal 50 ng - LEF Nov 2013 12 Nov, 2013
60,000 IU vitamin D monthly with Calcium was safe but not enough in the winter – 2012 03 Nov, 2013
60,000 IU vitamin D monthly with daily Calcium was safe but not enough in the winter – 2012 03 Nov, 2013
Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010 10 Aug, 2013
50,000 IU vitamin D 1-3 times per week helped obese patients in rehab. – May 2013 01 Aug, 2013
60,000 IU vitamin D weekly for 3 months lasts for another 3 months - April 2013 15 Jul, 2013
Fibromalgia reduced with 50,000 IU weekly vitamin D2 – Sept 2011 14 Dec, 2011
50,000 IU DAILY Vitamin D2 mistake detected after 2 months - March 2010 30 Nov, 2010
50,000 IU vitamin D suggested to prevent osteoporosis (weekly then monthly)– April 2019 No value for &#039;modification_date_major&#039;

Attached files

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3194 311-Vit D supplement Endoc Soc guidelines Harinarayan.pdf admin 02 Nov, 2013 1,010.34 Kb 1223