Weekly response to semi-activated vitamin D slightly better than standard – RCT

Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial

Nutrients. 2019 Nov; 11(11): 2778. online 2019 Nov 15. doi: 10.3390/nu11112778

Carmelinda Ruggiero,1,* Marta Baroni,1 Vittorio Bini,2 Annalisa Brozzetti,2 Luca Parretti,1 Elisa Zengarini,3 Maria Lapenna,1 Pierluigi Antinolfi,4 Alberto Falorni,2 Patrizia Mecocci,1 and Virginia Boccardi1

Notes: 1. Calcifediol (for humans) is far more expensive than standard Vitamin D 1. Calcifediol is typically only available by prescripttion 1. Many other studies consider Calcifediol potency to be 2X to 5X that of Vitamin D 1. Chart below appears to indicate response time for both is about one month * Many other studies find that it takes 3-6 months for all responses to plateau 1. Calcifediol is popular for.supplementing farm animals 1. Calcifediol =Calcidiol) --- * * Calcidiol category listing has items along with related searches** * Calcifediol (25(OH)D3) may be 4 X better than Vitamin D for fortification – Aug 2018 * Calcidiol increased blood levels of Vitamin D in one month (dogs) – Feb 2021 * Calcifediol (Calcidiol) might be a better form of Vitamin D for some people – May 2019 * COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020 * Oral calcidiol is a good form of vitamin D supplementation – Aug 2017 * Is HyD (25(OH)D) a better form of vitamin D for some animals and maybe humans with liver problems 1. Getting Vitamin D into your blood and cells has the following chart

📄 Download the PDF from VitaminDWiki

Note: Same 150 micrograms was given to both groups

150 micrograms of Vitamin D = 6,000 IU

iPTH Response ( lower is better)

Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment.

Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p < 0.001) and 1-25(OH)D (p = 0.01).

Participants on 25D3 experienced a steeper rise than those on D3 (grouptime interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (interventioniPTH interaction p = 0.04).

Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites.

In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels.