Vitamin D Video 53 minutes with text and PDFs – Grant
https://www.youtube.com/watch?v=jeLC_b5gDUM YouTube Video
Presentation on vitamin D to Smart Life Forum in Palo Alto on Oct. 17, 2017
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Slide titles
Vitamin D Physiology
Serum Calcium Regulation
Other Actions of Vitamin D
More Actions of Vitamin D
Skin Pigmentation
Human Skin Color Distribution
Recommendations
Leaders of the Two Camps
Vitamin D from UVB Exposure
Other Effects of UV Exposure
Those Most Likely to Have Low 25(OH)D Concentrations
Value of Measuring 25(OH)D
Benefits of Higher 25(OH)D(Partial List)
Colon Cancer Mortality Rates, White Males, 1950-69
Types of Cancer Reduced by UVB Exposure in the U.S.
Breast Cancer Incidence Odds Ratio vs. 25(OH)D Concentration
Cardiovascular DiseaseMeta-analysis
Seasonal Influenza
Pregnancy
Benefits of Vitamin D during Pregnancy
An estimate of the global reduction in mortality rates through doubling vitamin D levels.
Athletic Performance
From VitaminDCouncil.org by John Cannell (2010)
Autism Prevalence, White Children, vs. UVB dose for October
ADHD Prevalence 2007 From the CDC
Dental Caries Rate for Servicemen, 1918-1934 vs. UVB Dose
Dental Caries – Vitamin D Clinical Trials Hujoel, 2012
Sleep
Vitamin D and Verbal Fluency
Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults
Alzheimer’s and DementiaProspective Study 5.6 yrs
Erectile Dysfunction
Testosterone - 1, Testosterone - 2
Surgery
Where is Vitamin D Policy Headed?
Why Vitamin D Clinical Trials Should Be Based on 25(OH)D Concentrations
Variation of 25(OH)D Concentration with Oral Vitamin D Intake
Necessity for Vitamin D Clinical Trials
Why vitamin D clinical trials should be based on 25(OH)D concentrations - 2
English transcript
00:0X all right our next speaker is Bill I say
00:0X William B Grant has a PhD in physics
00:0X from the University of California Berkeley
00:1X in 1971 he has had a 30-year career in
00:1X atmospheric sciences with an emphasis on
00:1X laser remote sensing of atmospheric
00:1X constituents such as ozone and aerosols
00:2X with positions at s RI International the
00:2X Jet Propulsion Laboratory California
00:2X Institute of Technology and NASA Langley
00:3X Research Center he turned to health
00:3X research in 1996 publishing the first
00:3X paper linking diet to risk of
00:4X Alzheimer's disease in 1997 followed by
00:4X his studies of sugar fat and coronary
00:4X heart disease in 1998 and animal
00:4X products and cancer risk in 1998 in 1999
00:5X he turned his attention to the role of
00:5X solar ultraviolet B exposure in reducing
00:5X risk of many types of cancer through
01:0X production of vitamin D in 2012 after
01:0X retirement from NASA in 2000 2002 after
01:0X retirement from NASA in 2004 he moved to
01:1X San Francisco and formed the nonprofit
01:1X organization sunlight nutrition and
01:1X health research center which is WWN arc
01:2X AR CSUN AR c.org where he spends most of
01:2X his time studying the role of UVB solar
01:3X UVB exposure and vitamin D in reducing
01:3X risk of cancer and many other types of
01:3X disease he also investigates the role of
01:3X diet in risk of Alzheimer's disease in
01:4X cancer he has about 300 health
01:4X publications listed at WWE become of
01:4X which 210 are related to vitamin D with
01:5X 78% of these also on ultraviolet
01:5X radiation in human health and 41 to diet
01:5X and disease please welcome Bill Graham
02:0X thank you I'm delighted to be back here
02:0X again I really have enjoyed this
02:1X organization I like cork you invited me
02:1X into it about 12 or 13 years ago and
02:1X I've didn't involve ever since but don't
02:1X come to meetings very often now because
02:1X it's I'm in the San Francisco and it's a
02:2X long way down here and back let's see
02:2X there you go
02:2X I do receive funding from biotech pharmacal
02:3X that's a vitamin company as a
02:3X supplier of research grade vitamin D for
02:3X health professionals and consumers they
02:3X have a website biotech for McHale calm
02:4X so I'm going to discuss a number of
02:4X topics related to vitamin D this evening
02:4X first of all the vitamin D physiology
02:4X then I'm gonna put the binding
02:5X recommendations right up in front
02:5X because I think that's what you're most
02:5X interested in then I'll tell you why if
02:5X I'd be is important in terms of which
02:5X health outcomes are related to low
03:0X vitamin D whereas the Bundy policy
03:0X hitted so my latest research on how
03:0X vitamin D clinical trial should be
03:1X conducted and then tell you where to go
03:1X for additional information so vitamin d3
03:2X that's cholecalciferol can be made in
03:2X the skin or obtained from a food of
03:2X supplements there's also a vitamin d3
03:2X aerial cuss difficult which is made from
03:3X mushrooms or yeast or fun gene that's
03:3X not as effective as vitamin d3 it
03:3X doesn't last as long and it's not clear
03:4X that it has the same health benefits but
03:4X some people were vegans want to have no
03:4X animal products and all vitamin d3 is
03:4X made from animal products or almost all
03:4X there is a power plant source vitamin d3
03:5X but the vegans often want to go with a
03:5X d2 the liver converts vitamin d3 to – – –
03:5X hydroxy vitamin d3 by adding a hydroxyl
04:0X group and this is what is measured when
04:0X you go to the doctor's office and wonder
04:0X what your your blood level of vitamin D
04:1X is the half-life of this 25 hydroxy
04:1X Vaadin D is about two and a half
04:1X weeks now a kidney converts the 25
04:2X hydroxy body to 125 diet dihydroxy of
04:2X vitamin D and this this and the
04:3X parathyroid hormone PTH helped keep
04:3X serum calcium within a tight range the
04:3X 125 increases calcium absorption from
04:4X the intestines whereas a PTH increases
04:4X calcium absorption from the bones so we
04:4X have sort of a push and pull and so it's
04:4X there's not a direct correlation between
04:5X the amount of 25 and 125 but the more 25
04:5X you have the more 125 you can make there
05:0X are other actions of vitamin D and
05:0X that's what I primarily study most of
05:0X the action of vitamin D is through the
05:0X 125 entering the vine D receptors which
05:1X are coupled to chromosomes in there
05:1X every cell of the body when activated
05:1X the VTR's control the expression of many
05:2X genes up regulating most of them down
05:2X regulating others and it turns out that
05:2X not only a kidney can convert the 25 to
05:2X 125 but also other organs as needed
05:3X so for example you cancer someplace the
05:3X cells in that organ can also convert the
05:3X 25 to 125 and the skin it can convert 25
05:4X to 125 now Von D also fights bacterial
05:4X and some viral infections by inducing
05:5X production of Catholics seitan that's
05:5X the polypeptide with antimicrobial and
05:5X anti endotoxin properties fine B also
05:5X induces reduces inflammation by reducing
06:0X a production of pro-inflammatory
06:0X cytokines which are chemical messengers
06:0X to underscore the importance of vitamin
06:1X D for human health I note that skin
06:1X pigmentation varies globally depending
06:1X on where people live for hundreds to
06:1X thousands of years for example the the
06:2X Aborigines in Australia are very
06:2X dark-skinned their ancestors were from
06:2X the force of the Indonesia where
06:2X where they were brown-skinned but when
06:3X they got to Australia with no trees to
06:3X cover them they needed a very dark skin
06:3X to protect them from the very very
06:3X intense UV so dark skin in the tropics
06:4X reduces the risk of free radical
06:4X formation and skin cancer as well as
06:4X protecting against folate destruction
06:4X and folate is very important for
06:5X pregnancy and for pregnancy now as
06:5X humans moved out of Africa started
06:5X moving in northward they had to develop
07:0X lighter skin in order to make enough
07:0X vitamin D from the from the less intense
07:0X UV and they didn't need the protection
07:0X of the dark pigment against the free
07:1X radicals and full of destruction what
07:1X would happen they would get more
07:1X infectious diseases like tuberculosis
07:1X they would also get more rickets and
07:2X poor bone formation and so then the
07:2X pelvic cavity wouldn't be large enough
07:2X to let a feed on an infant come out in
07:2X the birth process and they hadn't
07:3X invented c-sections thousands of years
07:3X ago now Nina Jablonski and George
07:3X Chaplin and made a career out of going
07:4X around the world and measuring the un--
07:4X UV exposed pigment in many peoples
07:4X around the world and they have this
07:5X developed this map of skin pigmentation
07:5X they see very dark in the tropics where
07:5X you have no trees brown lighter color in
08:0X the tropical forest and very light in
08:0X the high latitudes so now let's go to
08:0X recommendations which I gave a talk in
08:1X Hungary last month and after I gave all
08:1X the information about what the benefits
08:1X are all I wanted to know was well how
08:1X much do I need how much should i what
08:1X should my level be so in 2011 the
08:2X Institute of Medicine announced that
08:2X adults up to the age of 7 years old
08:2X should have 600 ru per day over 70 years
08:3X they should have editor ru per day and
08:3X that 20 nanograms per milliliter vitamin
08:3X D concentration was 25 hydroxy vitamin E concentration
08:4X was just fine well it turns out that
08:4X that was a not a very sound study first
08:5X of all they were this was funded by the
08:5X Food and Drug Administration and the
08:5X National assistive health and Health
08:5X Canada and the two US organizations
09:0X worked very closely with Big Pharma and
09:0X also one of the organizers one of the
09:0X people on the committee had planned
09:1X another major vitamin E clinical trial
09:1X where people could take we're gonna take
09:1X 2000 IU of vitamin D per day in the
09:1X treatment arm but they got all my in the
09:2X treatment or the control arm could take
09:2X as much as the Institute of Medicine
09:2X recommended so in order not to sabotage
09:2X her clinical trial she pushed I think
09:3X very hard for these recommendations but
09:3X in order to reach these recommendations
09:3X they did three things which which are
09:3X not very scientific
09:4X first of all they ignored all non
09:4X skeletal effects they ignored cancer
09:4X cardiovascular disease autoimmune
09:4X diseases respiratory infections etc
09:4X second they demanded published
09:5X randomized controlled clinical trials of
09:5X a vitamin D and at a time when they did
09:5X a study all I could point to was
10:0X clinical trials for bone health
10:0X the third thing they did was they took a
10:0X study from Germany which looked at
10:0X people who died in automobile accidents
10:1X so they're healthy people just happen to
10:1X die prematurely and in the study they
10:1X they looked at the osteoid amount of the
10:2X bones noted as the unn mineralized
10:2X calcium in the bones sort of liquid or
10:2X gelatin life and they also compared the
10:3X 25 hydroxy vitamin D concentrations with
10:3X with the amount of this poor bone
10:3X mineralization and what they did was
10:3X they ignored the findings between 20 and
10:4X 30 nanograms in terms of they still had
10:4X a few at that point who had on
10:4X mineralized bone but they said that
10:5X wasn't important that most of the people
10:5X with underlies bone were below 20
10:5X nanograms so we're gonna stick with 20
10:5X he has been shown in many comments later
11:0X on that that was a major mistake and I
11:0X think the Institute of Medicine now
11:0X realizes that yeah but it took quite a
11:0X few years then I realized that now in
11:0X 2011 The Endocrine Society led by
11:1X Michael Holick team led by Michael
11:1X Holick published a recommendation for
11:1X dealing with a vitamin D deficiency now
11:1X it's the first one the Institute of
11:2X Medicine was for the general public healthy or not
11:2X the endocrine Society was dealing with
11:2X with people being treated by doctors
11:2X fortified in D deficiency so they
11:3X recommended a 1000 2000 IU per day of
11:3X item d2 or d3 and a serum vitamin e
11:3X concentration of around 30 nano grams
11:4X per milliliter at least they considered
11:4X 20 deficient between 20 and 30
11:4X insufficient above 30 sufficient however
11:5X there are finally advocacy organizations
11:5X which I'll name at the end who have
11:5X looked carefully at the the general
11:5X literature that comes out on a daily and
12:0X a weekly basis and have some of these
12:0X people have written peer-reviewed papers
12:0X on the benefits of item D and they've
12:0X looked at people with higher
12:1X concentrations and and how much better
12:1X they do in terms of athletic performance
12:1X or lack of disease and they're
12:1X recommending around 2,000 to 5,000 IU
12:2X per day vitamin d3 not skipping vitamin
12:2X d2 and a serum concentration of around
12:2X 40 to 60 nano grams per milliliter
12:2X one of the reasons for saying 40 to 60
12:3X is that looking at healthy Africans
12:3X modern-day Africans who are outdoors
12:3X every day with dark skin with with some
12:4X clothing I mean they're not not just
12:4X annoying Clause but they have a fair
12:4X amount of clothing on they have around
12:4X forty five nanograms per milliliter
12:5X serum 25 hydroxy vitamin D and so you
12:5X have these three recommendations so well
13:0X now just to show a picture here
13:0X Roger bouillon on the on the left is one
13:0X of the most prominent finally
13:0X researchers in Europe believe he's in
13:1X Belgium he's a lot of European leaders
13:1X are the 20 nanograms per milliliter camp
13:2X Michael Holick on the other hand is the
13:2X leader of the 13 anagram plus camp now
13:2X there are three sources of vitamin D the
13:3X sunlight is the primary source this map
13:3X this is a shows on the bottom is a month
13:4X of the year from from January through
13:4X December along the y-axis you have the
13:4X latitude from zero the tropics up to 90
13:5X degrees at the top and the colors
13:5X indicate how much time you have to be in
14:0X the Sun in order to make I see how much
14:0X well let's see if you okay if it's red
14:1X you cannot make any vitamin D if it's in
14:1X the blue the purple range you can make
14:2X some vitamin E it's gonna take longer
14:2X like maybe up to half an hour an hour to
14:2X be in the Sun and if it's black you can
14:2X make it fairly easily so we're about 30
14:3X degrees north latitude here so in the
14:3X winter we have a difficult time making
14:3X vitamin D but by March or April through
14:4X about October we can make a fair amount
14:4X of vitamin D and this this map was 400 – -
14:4X IU of a per day of vitamin D now if you
14:5X need 2,000 to 4,000 5,000 IU per day
14:5X this is the this scale would be changed
14:5X also it turns out that there's there's a
14:5X shadow rule the dermatologist like to
15:0X tell you if your shadow is shorter than
15:0X you are stay out of the Sun or cover up
15:0X or use sunscreen the vitamin E advocates
15:0X like to say unless your shadow is
15:1X shorter than you are you're not gonna
15:1X make much vitamin D so that means you
15:1X want to go out in your solar noon you
15:1X want to go out in the in the summer
15:1X spring summer and fall you want to
15:2X expose as much of your body as possible
15:2X you want to one of the reasons for going
15:2X out midday in addition is that the ratio
15:2X of UVA to UVB changes the shorter the
15:3X wavelength the more scattering there is
15:3X in the atmosphere and the way you can
15:3X tell that is the sky is blue and clouds
15:4X are orange so as a sunset sunrise the
15:4X Sun goes the sun rays go through a very
15:4X very large path and the shorter
15:4X wavelengths are scattering the
15:5X wavelengths much more rapidly than they
15:5X are the long wavelengths so the orange
15:5X gets to the clouds the blue gets to the
15:5X sky well UVB is much shorter than the
16:0X blue and so it's scattered even more in
16:0X fact even if you're under an umbrella
16:0X you're going to get UVB impinging on you
16:0X from the sides the the the the diffuse
16:1X scattering but the UVB the UVA is going
16:1X to be less scatter than UVB in fact UVB
16:1X is about three to five percent of total
16:2X UV and the rest is UVA
16:2X the problem with UVA is that it
16:2X penetrates the skin deeper and is more
16:2X important more responsible for melanoma
16:3X and basal cell carcinoma then UVB is so
16:3X if you went out morning evening you're
16:3X more likely to get melanoma but no
16:4X vitamin D so I was in a hungry last month
16:4X went over there ten conferences in
16:4X Warsaw and Thessaloniki and stopped off
16:5X in Budapest and found this this like a
16:5X porcupine with sign under saying Sun so
16:5X the Sun is one way to get your your your
17:0X vitamin D but you can also get it from a
17:0X solarium the indoor tanning booths maybe
17:0X have two to four percent UVB in the UV
17:1X if you go in for tanning you're going to
17:1X see how much longer they need to for
17:1X vitamin D production it turns out that
17:1X after you make that up to 20 thousand
17:1X international units of vitamin D from
17:2X whole body exposure in a Sun and half an
17:2X hour to an hour the body's that the UV
17:2X starts destroying the metabolites of
17:2X vitamin D so he can never make too much
17:3X vitamin D in the Sun now the other
17:3X sources of vitamin D are supplements and
17:3X diet and in terms of diet its animal
17:4X products like seafood but it turns out
17:4X that that a study in England found that
17:4X the people with the highest vitamin D
17:5X concentrations were not the fish eaters
17:5X it was the meat eaters the vegans had
17:5X the lowest amount the vegetarians a
17:5X little bit higher but there is about a
18:0X 1/8 nanogram per milliliter difference
18:0X between the meat eaters and the vegans
18:0X the reason is that meat has vitamin D as
18:0X 25 hydroxy vitamin D so most of the food
18:1X tables that talk about vitamin D do not
18:1X read do not include that in the study so
18:2X all these food frequency tables and how
18:2X much find here get from fewer eggs and
18:2X from your milk and so on they would find
18:2X about 250 to 300 IU per day in the American diet
18:3X not counting what's in a meat
18:3X and of course 250 and 300 are you per
18:3X day is not enough to to do much now
18:3X there are other effects of UV exposure
18:4X one thing you do is you get beta
18:4X endorphins which help reduce pain and
18:4X help you feel better
18:5X in fact the dermatologists realize that
18:5X people often go to tanning beds on a
18:5X regular basis because they get an
18:5X endorphin high and the claim is that
19:0X they're getting addicted to tanning
19:0X because of the beta endorphins mike my
19:0X thought is that anything that has
19:0X long-term benefits nature and sometimes
19:1X provides short-term benefits to make you
19:1X understand that their long-term benefits
19:1X and so I think there's a you know should
19:1X be applauded rather than criticize
19:2X another thing is you can release my
19:2X trick oxide subcutaneous nitrogen
19:2X compounds which can lead to lower blood
19:2X pressure in fact if you look at the
19:3X latitudinal distribution of blood
19:3X pressure it's lowest in the tropics and
19:3X highest in the high latitudes of course
19:3X that could also be related to dietary
19:3X factors but but it could be related to
19:3X some what - to UV there are some we'll
19:4X see multiple sclerosis has a very
19:4X pronounced latitudinal effect and four
19:4X years of thought that that was because
19:5X of vitamin D production but now both
19:5X human studies and and animal studies
19:5X have indicated that there are benefits
19:5X of UV aside from vitamin D production
20:0X that reduced the risk of multiple
20:0X sclerosis of course there are other
20:0X effects you can reset your biological
20:0X clock through the blue light around 420
20:1X nanometers I found out when I went to
20:1X say Sweden in February I was there for
20:1X two weeks and never got on Swedish time
20:1X and last month I was in in Warsaw for a
20:2X week and it rained every day and I did
20:2X not get on Warsaw time finally in in
20:2X Budapest I started with sunlight I start
20:2X to get over on the European time also
20:3X turns out that as I was so later than
20:3X just getting outside and exercising is
20:3X very beneficial and has health effects you
20:4X tentative of vitamin D so those most
20:4X likely to have low vitamin E
20:4X concentrations are those spending most
20:4X time indoors this will also include
20:5X those who have do shift work and sleep
20:5X during the day because they work at
20:5X night not being the Sun nurse solar noon
20:5X went with sufficient body surface
20:5X exposed dark-skinned people I'm working
21:0X on a manuscript on the health benefits
21:0X of vitamin D for dark-skinned people in
21:0X the United States we're going to Bruce
21:0X Ames on this and see if the average the
21:1X mean casa
21:1X 25 hydroxy vitamin d concentration for white
21:1X adult American Americans is around 21 ?
21:2X nanograms per milliliter of course our
21:2X seasonal variation is gonna be a factor
21:2X of 2 between summer and winter for
21:2X Hispanics is more like 21 nanograms and
21:3X for black Americans and more like 1 ?
21:3X nanograms so yeah in Africa they had all
21:4X the vitamin E they needed but not here
21:4X in the United States those who are
21:4X overweight or obese I generally have
21:4X much lower body concentrations than
21:4X those who are normal weight wearing
21:5X sunscreen or even wearing using skin
21:5X lightening cream reduces the vitamin E
21:5X production and it turns out older folks
22:0X over the age of 60 and perhaps even
22:0X little bit younger have less of the 7 d
22:0X high high low cholesterol in a thinner
22:0X skin that that is converted to two
22:1X vitamin D and salami didn't may need to
22:1X stay in the Sun two to three to four
22:1X times longer to make the same amount of
22:1X vitamin D so there are values of
22:2X measuring 25 hydroxy vitamin D and also
22:2X turns out that even if you take a
22:3X thousand or 2,000 I you if I marry per
22:3X day there's a large variation in the
22:3X response to to vitamin D some people may
22:4X make twice as much 25 from the same out
22:4X of oral vitamin D and turns out it
22:4X depends on whether you take it with a
22:5X large meal so it goes slow
22:5X intestines whether you're taking more
22:5X magnesium to help conversion 225 etc etc
22:5X so if you really want to know where your
23:0X your concentration is you really ought
23:0X to have your 25 hydroxy vitamin D
23:0X measured you can have your doctor do it
23:0X but you can also go to grassroots health
23:1X net or the Van Dien Council org and both
23:1X of them sell a blood spot kit and you
23:2X get a little Lance you draw three or
23:2X four spots of blood and put it on a card
23:2X there's dried blood just sent back to
23:2X them they they sent it to a laboratory
23:2X and they it's very accurate they use
23:3X Hema they use an average Hema crit value
23:3X for the entire population around well so
23:3X if your Hema crypt is somewhat different
23:4X from from normal that might be a slight
23:4X error but I've checked it out some time
23:4X ago and when I was taking more like
23:4X $5,000 per day and I got 65 67 and 6 -?
23:5X nanograms per milliliter depending on
23:5X the blood spot test
23:5X and two of the wet chemistry labs so I
24:0X think they're quite a Qi accurate
24:0X grassroots health also has a program
24:0X where you can have your your 25 hydroxy
24:0X dividing measured every six months and
24:1X you're then entered into a scientific
24:1X study they want you to stay in it for
24:1X about five years they'll ever ask your
24:1X health question how's your health what
24:1X did you did you fall did you get sick
24:1X etc etc and they've actually used these
24:2X results in several peer-reviewed
24:2X publications so now we get into the
24:2X benefits why you really want vitamin D
24:3X I'm gonna skip bones because I really
24:3X haven't study bones that was sort of the
24:3X classical vitamin D area and it's been
24:3X the last almost two decades now that the
24:4X non skeletal effects have become very
24:4X important and that's what I've studied
24:4X so there's cancer there's respiratory
24:4X tract infections there's adverse
24:5X pregnancy and birth outcomes premature
24:5X death autism and ADHD dental caries poor
24:5X sleep cognitive dysfunction Alzheimer
25:0X disease erectile dysfunction and low testosterone
25:0X so there's said to be something for
25:0X everybody in here if not you your
25:0X children or your grandchildren so the
25:1X the first link between UV exposure and
25:1X lower risk of cancer was made by the
25:1X brothers cedric and frank garland who as
25:2X beginning graduate students at johns
25:2X hopkins school of public health and
25:2X knights en 74 saw a map something like
25:2X this it only had five color scales
25:3X instead of ten but they saw that there
25:3X was lower colon cancer in the southwest
25:3X in higher colon cancer in northeast they
25:3X just driven driven from Sandy Hill to
25:4X Maryland and then it was very sunny in
25:4X the southwest and not very sunny in the
25:4X Northeast so they hypothesized that
25:4X since the primary the
25:5X largest physiological effect of sunlight
25:5X is widen D production that bottom D must
25:5X reduce the risk of cancer well it took
26:0X them six years to get that paper
26:0X published and then it was an in a
26:0X British Journal which is finally finally
26:0X published in but nobody really took much
26:1X notice of it in 1985 they show that
26:1X dietary vitamin D was linked to low
26:1X cancer risk in 1989 they showed that low
26:2X serum 25 hydroxy vitamin is linked to
26:2X low colon cancer risk
26:2X they also extended this to breast cancer
26:2X and ovarian cancer somebody else did
26:3X prostate cancer and lymphoma but you can
26:3X understand that since no I was gonna get
26:3X rich selling vitamin D or selling
26:4X sunlight that the medical system had
26:4X just sort of said not much so I came
26:4X along in 1999 after doing some work
26:4X mentioned on on dietary factors and I
26:5X saw these new maps that were published
26:5X by the National Institutes of Health and
26:5X I saw all the read of the Northeast
27:0X except for prostate cancer was in the
27:0X northwest and I said gee maybe I can
27:0X explain this based on dietary factors
27:0X well I took two weeks to realize that we
27:1X eat the same food countrywide except in
27:1X the South would have Allah barbecue now
27:1X if you look at these you'll see very
27:1X similar patterns breast
27:1X again high mortality rates in the Northeast
27:2X but you have some also some high breast
27:2X cancer rates along the West Coast turns
27:2X out that along the coast you have more
27:2X clouds and fog and so people are not
27:3X getting as much UVB along the coast that
27:3X they were inland so breast cancer is not
27:3X quite as strong a link between UVB
27:3X Vaughn B and in reduced risk as colon
27:4X cancer for kidney cancer you'll see down
27:4X in Louisiana some hot spots that's
27:4X because of the chemicals in the chemical
27:5X manufacturing there stomach cancer you
27:5X sees a lot of red along the Mexican border
27:5X that's because of hygiene and much more
27:5X h pylori in among mexicans so we get
28:0X more stomach cancer prostate cancer is weird
28:0X you see the red now is shifted more to
28:0X the northwest and the blue more to the
28:1X southeast it turns out that both low and
28:1X high 25 hydroxy vitamin D have about the
28:1X equal risk for prostate cancer there's
28:2X some benefit of Von D in fighting
28:2X aggressive prostate cancer but it turns
28:2X out that that calcium is an important
28:3X risk factor for prostate cancer and
28:3X since one of the benefits of the effects
28:3X of vitamin D is to increase absorption
28:3X of calcium it could be that there's a
28:4X sort of a trade-off between having too
28:4X much vitamin D and inducing too much
28:4X calcium absorbtion that may play a role
28:5X here it's still being debated by the the
28:5X in the peer review literature I don't
28:5X have a definitive answer on that but so
28:5X what I did I got the NASA data for UVB
29:0X at the surface for July 1992 and you see
29:0X it's very asymmetrical the the highest
29:1X rates are in the southwest Arizona New
29:1X Mexico the lowest rates are northeast
29:1X and the reason you have higher UVB in
29:1X the west and an East is that the surface
29:1X elevation tends to be higher we have
29:2X more mountains and and even the arm like
29:2X the Nevada desert is higher than
29:2X then than a sea level and then you have
29:2X the westerly winds have to cross the
29:3X Rocky Mountains and in doing so they
29:3X pushed the tropopause higher and make
29:3X the stratospheric ozone layer thinner
29:3X and it's the ozone in the stratosphere
29:3X that blocks the UVB so you have less
29:4X absorption unless scattering in the
29:4X atmosphere so you have more UVB here in
29:4X the east you also have more clouds and
29:5X aerosols which is not reflected in this
29:5X map but but also plays a role so from
29:5X ecological studies we found about 15 to
30:0X 20 types of cancer that are reduced from
30:0X UVB exposure and we think and we have
30:1X evidence for a lot of these that higher
30:1X 25 hydroxy vine D levels are correlated
30:1X with lower cancer risk
30:1X so either incidence or mortality rates
30:2X so it's colon esophageal laryngeal oral
30:2X pharyngeal rectal small intestine the
30:2X female cancers breast in the material
30:3X ovarian and Evolver urogenital bladder
30:3X kidney prostate and testicular
30:3X miscellaneous organs gallbladder lung
30:3X pancreatic and thyroid and the blood
30:4X cancers lymphoma leukemia non-hodgkins lymphoma
30:4X now how much vitamin what's the
30:5X correlation between 25 hydroxy vitamin D
30:5X and cancer incidence well I made this is
30:5X sort of a graphical meta-analysis now
31:0X I've taken 11 studies from seven
31:0X countries and merge them together by
31:1X adjusting the the odds ratio with
31:1X respect to the 25 hydroxy Von D so
31:1X they're all laying the same line and now
31:2X the units here are Nana moles per liter
31:2X you divide by 2.5 to get nanograms per
31:2X milliliter so what you see is below
31:2X about 20 nanograms you get a steep rise
31:3X in the risk and when you get out to
31:3X about 40 nano grams you still have some
31:3X reduced risk but you're slowing down
31:4X the the the the increase the reduction
31:4X in odds ratio the the dash dash lines
31:5X and outside shield a 95% confidence
31:5X intervals there was this is the
31:5X uncertainty from the measurements
32:0X I mean sorry we have a this slope like
32:0X this and this seems to be typical for
32:0X other health outcomes as well although
32:0X for some diseases you may be a threshold
32:1X at twenty or thirty nanograms more than
32:1X forty or fifty nanograms like for cancer
32:1X and now we have results from this was a
32:2X recent clinical trial conducted into
32:2X Nebraska with postmenopausal women with
32:2X an average BMI of about 31 and a
32:3X baseline 25 hydroxy vitamin D of around
32:3X 33 nanograms
32:4X body mass index BMI so these were obese
32:4X people on average with high 25 hydroxy
32:4X but indeed there were about a I think
32:5X was a thousand women involved for four
32:5X years and they were given $2,000 per day
33:0X plus about a gram of calcium or placebo
33:0X or yeah or placebo and it turns out that
33:1X in the clinical trial in the
33:1X intention-to-treat they had one more
33:1X cancer case in the treatment arm then
33:1X then would be the case if they had less
33:2X than a one in 20 chance that this was a
33:2X an effect found by chance there was a P
33:2X was less P was 0.06 instead of 0.05 and
33:3X so when the papers published JAMA said
33:3X on news release saying clinical trial
33:3X shows that vitamin D does not
33:3X significantly reduce the risk of cancer
33:4X but the people at Creighton University
33:4X along with with people from grassroots
33:4X health and Keith beggarly said now wait
33:4X a minute if we look at the serum 2X 33:5X hydroxy of
33:5X the most the most recent measurement
33:5X before they developed cancer we find
33:5X that those that had between 40 and and
34:0X 80 nanograms per milliliter has
34:0X significantly reduced risk of cancer
34:0X compared to those with less than 4 -“
34:1X nanograms familiar but since they have
34:1X not specified this as an outcome in the
34:1X protocol JAMA made them put it in the
34:1X online appendix the supplementary files
34:2X which was not seen by most people
34:2X Creighton University however issued a
34:2X press release saying see we found a
34:2X benefit and so we had the two competing
34:3X press releases and that who have people
34:3X saw both were a little confused for
34:3X cardiovascular disease here's another
34:3X observational study meta-analysis
34:4X showing that below 20 nanograms per
34:4X milliliter there's an increased risk of
34:4X cardiovascular disease unfortunately
34:4X there have been no clinical trials that
34:5X have confirmed that giving people
34:5X vitamin D and reduce the risk of
34:5X cardiovascular disease so the question
34:5X is is this maybe because they are out of
35:0X doors more maybe they're exercising more
35:0X out of doors maybe they're eating
35:0X different diet or is there vitamin D
35:0X maybe it's a long-term vitamin D effect
35:1X and if you do a two to four year study
35:1X you don't find the effect so this is
35:1X still sort of up in the air about
35:1X cardiovascular disease seasonal
35:2X influenza dr. John Connell who runs the
35:2X vitamin D council proposed in 2006 that
35:2X influenza was largely seasonal due to
35:3X seasonal variations and UVB doses he had
35:3X been given being giving his he worked at
35:3X a task Adaro hospital for the clinically
35:3X insane he'd been giving his patients
35:4X 5000 IU per day and in 2004-2005 when an
35:4X influenza epidemic came through the area
35:4X his patients were largely spared so they
35:5X got him thinking about well maybe
35:5X vitamin D does reduce the risk of
35:5X influenza in fact shortly after his
35:5X papers published the results of a
36:0X clinical trial involving postmenopausal
36:0X women in Long Island was was reanalyzed
36:0X and they found that indeed those taking
36:0X $2,000 per day had very few influenza or
36:1X cold events whereas those taking 800 had
36:1X several and those taking 400 are you had
36:1X quite a few so that was one clinical
36:1X trial that that showed that yes finally
36:2X done reduce did reduce the risk of
36:2X influenza and then a one involving
36:2X Japanese school children show that it
36:2X reduced type a but not type B influenza
36:2X I might add that cold temperature and
36:3X low humidity also in contribute to the
36:3X seasonality because the influenza virus
36:3X lives better in a cold dry environment
36:4X so that's why it can be passed from
36:4X person to person in the winter but on
36:4X the other hand it's the volunteers can
36:4X help you induce Catholic sidon to fight
36:4X the influenza pregnancy clinical trials
36:5X in South Carolina found that pregnant
36:5X women have better pregnancy and birth
36:5X outcomes by taking 4060 400 IU per day
36:5X of 1 D 3 and reaching 40 nanograms per
37:0X milliliter 25 for dr. c ymd the reason
37:0X is that above 40 nanograms
37:0X the 125 dihydroxy of vitamin D
37:1X concentration is stabilized
37:1X leaving to improve gene expression and
37:1X there's ever a period of life when gene
37:1X expressions important is during the
37:2X fetal development period so the benefits
37:2X of IMD during pregnancy includes reduced
37:2X risk of primary c-section delivery on
37:2X c-section delivery
37:2X well vaginal delivery is important to
37:3X give the the infant the the gut biome it
37:3X needs to to get off to healthy immune
37:3X start reduced risk of gestational
37:3X diabetes reduce risk of preterm birth
37:4X and for the infants reduced risk of low
37:4X for gestational weight reduced risk of
37:4X autism and reduced risk of asthma this
37:5X is from the studies in South Carolina
37:5X and it's showing that below below twenty
37:5X six point five nanograms per milliliter
37:5X there's a reduction in the gestational
38:0X age above that there seems to be a
38:0X plateau so here's another benchmark for
38:0X pregnant women in terms of overall age
38:1X adjusted mortality rate standard Garlin
38:1X and company advertised
38:1X analyzed 32 observational studies and
38:2X found that it took 36 nanograms per
38:2X milliliter before the mortality rates
38:3X plateaued and you see there's a pretty
38:3X much a linear rise to twice the
38:3X mortality rate at lower local of 1 -?
38:4X nanograms familiar as adult mortality so
38:4X I've done my own analysis where I looked
38:5X at disease rates in in various countries
38:5X and the observational studies for the
38:5X relationship between 25 hydroxy body and
39:0X the incidence or mortality rate and
39:0X found that if everyone well the global
39:0X average 25 hydroxy varney is around 2 -?
39:1X nanograms it turns out because of skin
39:1X pigmentation varying no matter whether
39:1X you where you live the population
39:1X average is around 22 nanograms unless
39:1X you're in the Middle Eastern country and
39:2X where to any close then it's gonna be
39:2X lower if you're african-american it's
39:2X gonna be lower and so on but anyway if
39:2X you increase from 22 to 44 nanograms it
39:3X appears that the vitamin d sensitive
39:3X mortality rate would reduce by about 2 -? percent
39:3X and that's accounts for about half of a
39:3X and the deaths and so this would lead to
39:4X a life expectancy increase in about two years
39:4X athletic performance again John Cornell
39:4X wrote a paper I think into 2009 and he
39:5X went through a number of reasons why he
39:5X thought that there'd be better athletic
39:5X performance for one thing he point out
39:5X that the Mexican Olympics 1968 had a lot
40:0X of World Records and a lot of people had
40:0X gone there to to practice before had to
40:0X get used to the altitude he thought it
40:0X was not the altitude but the UVB and the
40:1X vitamin D so he published this 2009 in a
40:1X sports medicine journal and as a result
40:1X the Chicago Blackhawks became the first
40:2X vitamin team in modern professional
40:2X sports became the first time the team in
40:2X modern professional sports history and
40:2X according to John sources the Black Hawk
40:3X team physician became began diagnosing and treating
40:3X finding efficiency in all blackhawk
40:3X players about 18 months ago written in
40:3X 2010 and apparently most players were
40:4X taking 5,000 IU per day after losing
40:4X many seasons last year the Blackhawks
40:4X came out of nowhere to get the Western
40:4X Conference Finals
40:4X this year they're playing even better so
40:5X one thing is going to do is reduce their
40:5X risk of influenza and Kohl's and all
40:5X sorts of other respiratory infections
40:5X the other thing is going to do is reduce
40:5X the risk of stress fractures another
41:0X thing a faster healing of wounds so very
41:0X important
41:0X Don and I to John also wrote the first
41:1X paper on vitamin D and the risk of
41:1X autism I worked with him in 2013 we got
41:1X the Provost data for children ages 6 to
41:2X 17 years as a function of state I looked
41:2X at those versus UVB doses in the summer
41:2X for the well actually of October and
41:2X found that there was an inverse
41:3X correlation between UVB and risk of
41:3X autism it turns out that African
41:3X Americans have higher rates of autism
41:3X than white Americans their darker skin
41:4X making less vitamin D and there are
41:4X mechanisms to explain why find D
41:4X deficiency in both in in in utero and
41:5X early life would lead to increased risk
41:5X of autism ADHD it has a pattern which
42:0X you see the lower rates in the Southwest
42:0X higher rates in the east and northeast
42:0X again as sort of looks like the UVB
42:1X inverse of UVB dental carries it turns
42:1X out that there were data from the 20s
42:1X 30s and 40s if I plotted the the the
42:2X dental health rank versus UVB dose you
42:2X see that below about 6.5 kilojoules per
42:3X meter squared there was a linear slope
42:3X upwards and above that there was a
42:3X plateau in fact even a paper from 186 -?
42:3X showed that if you looked at the Union
42:4X Army soldiers those from Maine and New
42:4X Hampshire had lost quite a few teeth
42:4X why time you got to Kentucky or so they
42:4X had most of T still intact so even then
42:5X there was an effect of UV on dental health
42:5X in fact the first clinical trial on
42:5X vitamin D was for children in England in
43:0X 1928 giving them body and looking at
43:0X dental caries and they found that yes
43:0X they reduce the risk of dental caries
43:0X and the woman doing this study said that
43:1X the bacteria were dead
43:1X she didn't know why but we know why now
43:1X and this here shows that that there were
43:1X a number of studies never clinical
43:2X trials in the 30s and 40s
43:2X we showed a 50% reduction in dental
43:2X caries for children taking a vitamin
43:2X game sleep turns out that raising 2 -?
43:3X hydroxido into 60 to 70 grams per
43:3X milliliter does improve sleep however
43:3X the women doctor gummy enact doing this
43:3X study found that after two years the
43:4X people who started reporting systemic
43:4X pain one of her patients helped her
43:4X realize that it was because they were
43:5X becoming a vitamin D vitamin B deficient
43:5X the back gut bacteria producing finally
43:5X when you sleep you restore the body
43:5X through methylation and methylation
43:5X requires B vitamins and so they're using
44:0X up some of the vitamins in the gut and
44:0X when she gave them be 104 which has the
44:0X multiple beef in a couple months they
44:0X got the gut back in shape and pain went
44:1X away and they were fine there's also
44:1X fine the verbal fluency cognitive decline
44:1X there's Alzheimer's disease and dementia
44:2X this looks like below 20 nanograms
44:2X there's a problem erectile dysfunction
44:2X below 20 nanograms per milliliter
44:3X testosterone there's a study involving
44:3X obese people in Austria and they found
44:3X that by giving them vitamin D they did
44:3X increase their testosterone in fact I've
44:4X myself and two other men taking high
44:4X doses of vitamin D found that when they
44:4X were up around 60 or 70 nanograms per
44:4X milliliter that they got the
44:4X testosterone up so it's a in fact that
44:5X could help improve athletic performance
44:5X because testosterone helps muscles
44:5X surgery turns out that people who go
45:0X into surgery with higher 25 hydroxy
45:0X Vandy recover more quickly
45:0X wounds heal faster burns heal faster so
45:1X whereas widened D policy headed well we
45:1X have four or five or six major one D
45:1X supplementation trials which will
45:2X complete data collection this year next
45:2X year and then analyze the results they
45:2X generally use about 2000 IU per day or
45:3X $100,000 per month and these studies as
45:3X imperfect as they are will provide the
45:3X basis for the next recommendations I was
45:4X just in Warsaw this is a committee
45:4X reviewing posters by the mrs. Michael
45:4X Holick in front looking carefully at
45:4X that posters so I published a paper
45:5X recently saying why the clinical trial
45:5X should be based on vitamin D on 2 -?
45:5X hydroxy Von D because most the trials
46:0X are based on the assumptions used for
46:0X pharmaceutical drugs first of all that
46:0X the trial is a sole source of the agent
46:1X and second that there's a linear
46:1X dose-response relationship between the
46:1X agent and the health outcome
46:1X neither assumption is valid for vitamin
46:2X for vitamin D and also it turns out many
46:2X of the trials do not follow to measure
46:2X 25 hydroxy vitamin D they just you know
46:3X think you take the average healthy
46:3X person and so they get a healthy person
46:3X affect that there's no benefit of more
46:3X vitamin D here we show that from the
46:4X grassroots health data set that for
46:4X people taking any reporting that they're
46:4X taking any value of oral vitamin D that
46:5X there's about a 50 nanogram spread plus
46:5X or minus 15 intagram of the 25 hydroxy
46:5X vitamin D concentration that's why if
46:5X you really wanna know what your vitamin
47:0X E level is you gotta have it measured it
47:0X turns out that why do we need clinical
47:0X trials well observational studies could be
47:1X being using the 25 hydroxy of any
47:1X concentration as an indent of diet or of
47:1X UVB exposure it turns out for example
47:2X that meat consumption increases
47:2X literally from the from the tropics
47:2X highest consumption racer and the high
47:2X latitudes if you have mechanisms you
47:3X don't know how much how important Von D
47:3X is in reducing risk the health systems
47:3X most of clinical trials as a gold
47:3X standard we're now in the evidence-based
47:3X medicine
47:3X era as imperfect as it is but they're
47:4X trying in Budapest there's a lot of meat
47:4X being sold and so they get to increase
47:4X the risk of cancer and alt and
47:5X Alzheimer's disease but they're getting
47:5X some vitamin D so it's a bit of a
47:5X trade-off so anyway we're proposing that
47:5X all these trials be based on 25 hydroxy
48:0X Von D including the imaging beforehand
48:0X choosing the participants give enough
48:0X item D to raise 5 D levels high
48:0X measuring ans cetera et cetera
48:1X now why you've never heard about the
48:1X whole truth about vitamin D this is from
48:1X natural news.com well there's the
48:1X Federal Trade Commission that tells
48:2X tanning companies they cannot advertise
48:2X that tanning produces vitamin D big
48:2X pharma see is that as competition komen
48:3X Race for the Cure they don't want to
48:3X cure there they don't want to prevent
48:3X breast cancer they want to manage for
48:3X breast cancer the FDA they help sponsor
48:3X the Institute of Medicine report there's
48:4X oncologists who make fifty thousand
48:4X hundred thousand dollars in treating
48:4X cancer ten dollars a year for vitamin E
48:4X to prevent cancer no you don't want that
48:5X and the National Cancer Institute
48:5X so grassroots well okay I'm a co-author
48:5X on a book coming out shortly called
49:0X embrace the Sun mark Sorenson is the
49:0X primary author and dr. T who spoken here
49:0X before is doing a very careful text
49:0X editing Michael Holick wrote the
49:1X foreword for this this should be
49:1X available in November or December and
49:1X you can contact me and we can tell you
49:1X how to get it now for more information go to
49:2X med which has 27 million health
49:2X publications listed there you can
49:3X finally access with scholar.google.com
49:4X who spends all his waking hours making
49:4X bundy information accessible finding
49:4X counsel in nevada new society a society in cancer
49:5X thank you okay great thank you it's
49:5X really refreshing to hear someone talk
49:5X about being in the sun is it really good for you
50:0X we're gonna push a little bit beyond
50:0X where we would normally try to stop i
50:0X want to take a couple of questions if we
50:0X have them and then we need to start then
50:1X we can continue yeah after the
50:1X informally so any question i'm for the
50:1X group here right doesn't heal per day
50:2X but what are the consequences well the
50:2X primary consequence of too much of
50:2X vitamin D is hypercalcemia if you get
50:3X hypercalcemia you don't feel good and so
50:3X these people are taking fifty thousand
50:3X definitely feel fine they do have very
50:4X high 25 hydroxy Von D concentrations I
50:4X guess we'll just have to see what happens
50:4X it stores though the same 50,000 a year
50:5X saying but if you took it yeah if you
50:5X took it once a week or hmm
50:5X yeah the vitamin E can store in the fat
51:0X and the muscles the 25 has a short
51:0X half-life I'm hoping you would ask a
51:0X question first of all thank you for your
51:1X contributions to the scientific
51:1X community second of all so I have my
51:1X understanding is UVB is the best from 1 -?
51:1X a.m. to 4 p.m. and what would you
51:2X recommend like 20 to 25 minutes in the
51:2X sunlight well more like 10 to – ?
51:2X and it depends on how much skin you can
51:3X expose and your skin pigmentation so if
51:3X you're fair-skinned and mixed pros let's
51:3X say a young person exposing 10% of his
51:4X body can maybe make after you 20 or 30 I
51:4X you per per minute maybe so maybe 25 to
51:4X 15 minutes for a young person it might
51:5X be enough but if you can expose a
51:5X quarter of your body that's better you
51:5X cut down the time there are there are
51:5X UVB meters out that tell you how much
52:0X time you has been made thank you I'll
52:0X check that out okay one more quick okay
52:0X so that's Daly but if you only get out
52:1X once a week but you're out for six to
52:1X ten hours and the half-life is long
52:1X enough you can get enough that way also
52:1X correct yeah you can make twenty
52:2X thousand in a day so and you can store
52:2X the X and the half-life is two and a
52:2X half weeks and you can store the excess
52:2X vitamin D so that would probably do okay
52:3X that's good do you mind go ahead and ask
52:3X your question one on one or the one
52:4X where the people are taking and then
52:4X they're measuring the dosages about four
52:4X from the end or so is that published
52:4X somewhere that seems like a really
52:5X important okay we'll go ahead why don't
53:0X you go ahead and finish this one yeah
53:0X let's complete the evening thank you all
53:0X for coming we meet the third Thursday of
53:1X every month you