Vitamin D supplementation is associated with slower epigenetic aging

Created June 2022

Vitamin D supplementation is associated with slower epigenetic aging

GeroScience https://doi.org/10.1007/s11357-022-00581-9

Valentin Max Vetter • Yasmine Sommerer, Christian Humberto Kalies • Dominik Spira •, Lars Bertram • Ilja Demuth

1,000 seniors living in Berlin * Took 5 gene aging tests and a Vitamin D test * 7 years passed * Again took the same 5 gene aging tests and a Vitamin D test Some of the Germans who had been deficient (<20 ng) supplemented got to >30 ng The ("treated") aged more slowly (a negative score) than those who did not supplement For most of the tests, they aged even less than those who had been > 30 ng For all of the tests, they aged less (more negative scores) than those who remained deficient

Adverse effects of low vitamin D level on mortality and morbidity are controversially discussed. Especially older people are at risk for vitamin D deficiency and therefore exposed to its potentially harmful consequences. A way of measuring differences in the biological age is through DNA methylation age (DNAm age) and its deviation from chronological age, DNAm age acceleration (DNAmAA). We previously reported on an association between vitamin D deficiency and higher 7-CpG DNAmAA in participants of the Berlin Aging Study II (BASE-II). In this study, we employ a quasi-interventional study design to assess the relationship between DNAmAA of five epigenetic clocks and vitamin

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VitaminDWiki pages with EPIGENETIC in title (16 as of June 2022)

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Epigenetic Role of Vitamin D: 56 minute video - May 2022

Dr. Eduardo Beltran

An Epigenetic Approach for Treating Autoimmune Diseases. HDVD Therapy + Anti-inflammatory Diet! In this presentation we will talk about:

1.) Dysbiosis

2.) Leaky Gut Syndrome Pathogenesis

3.) Relationship between Fiber-Mucin-Tight Junctions & Vitamin D3

4.) Leaky Brain Syndrome

5.) Fetal Susceptibility Hypothesis

6.) Nutrigenomics and SNPs

7.) Vitamin D Genes and SNPs

8.)VDR Cleansing Through Diet Modification (Anti-inflammatory Diet)

Vitamin D and Omega-3 may reverse epigenetic aging - Drs. Patrick and Horvath video May 2022

video

Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

Note: Horvath is the name of one of the aging clocks in the German study

Epigenetics & "vitamin d" in Google Scholar: includes 6 studies with PDFs

30,000 Items as of June 2022

Vitamin D supplementation is associated with slower epigenetic aging = May 2022 📄 PDF
Epigenetic Clock: A Novel Tool for Nutrition Studies of Healthy Ageing - April 2022 📄 PDF
Epigenetic Aging in Early Life: Role of Maternal and Early Childhood Nutrition - Feb 2022 📄 PDF
Epigenetics in Food Allergy and Immunomodulation - Dec 2021 📄 PDF
Analysis of epigenetic changes in vitamin D pathway genes in rheumatoid arthritis patients - 2021 📄 PDF
Vitamin D: a Review of its Effects on Epigenetics and Gene Regulation - Dec 2020 📄 PDF
Epigenetics Predicts Serum 25-Hydroxyvitamin D Response to Vitamin D 3 Supplementation in African Americans - Jan 2020 https://doi.org/10.1002/mnfr.201900738

Tags: Seniors