Vitamin D should reduce hospital-acquired infections – Grant

Vitamin D's potential to reduce the risk of hospital-acquired infections

Dermato-Endocrinology Volume 4, 2012 - Issue 2 Dec 2021 https://doi.org/10.4161/derm.2078

Dima A. Youssef, Tamra Ranasinghe, William B. Grant. Alan N. Peiris

Table of contents

Burden of Hospital-Acquired Infections

Antimicrobial Role of Vitamin D

Use of Vitamin D in Infectious Diseases

Bacteremias and Central Vascular Catheter-Associated Bloodstream Infections

Health Care-Associated Pneumonia and Hospital-Acquired Pneumonia

Clostridium difficile Infections

Catheter-Associated Urinary Tract Infections

Surgical Site Infections

Infections due to Virulent Organisms, such as MRSA

Appropriate Dose of Vitamin D

Clipped from PDF

"To note that most recently, Cannell announced that it has become possible to prescribe vitamin D3, as 50,000 IU once weekly , and it can also be prescribed as once every 2 weeks.118"

Health care–associated and hospital-acquired infections are two entities associated with increased morbidity and mortality. They are highly costly and constitute a great burden to the health care system. Vitamin D deficiency (< 20 ng/ml) is prevalent and may be a key contributor to both acute and chronic ill health. Vitamin D deficiency is associated with decreased innate immunity and increased risk for infections. Vitamin D can positively influence a wide variety of microbial infections.

Herein we discuss hospital-acquired infections, such as pneumonia, bacteremias, urinary tract and surgical site infections, and the potential role vitamin D may play in ameliorating them. We also discuss how vitamin D might positively influence these infections and help contain health care costs. Pending further studies, we think it is prudent to check vitamin D status at hospital admission and to take immediate steps to address existing insufficient 25-hydroxyvitamin D levels.

📄 Download the PDF from VitaminDWiki

---

See also VitaminDWiki

• 42 studies with GRANT in VitaminDWiki title as of Dec 2022

• Doctors Still Struggle to Diagnose a Condition That Kills More Than Stroke (Sepsis, Vitamin D helps) Oct 2022

• Vitamin D is needed before many surgeries – many studies and RCTs

• Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014

• Surgical Site Infection 4X more likely if low vitamin D – Aug 2019

• Low vitamin D at ICU admission is associated with cancer, infections, acute respiratory insufficiency and liver failure – Oct 2018

• Hospital Acquired Infection, Mortality, Critically Ill and Vitamin D - 2017

• Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies

• Having less than 15 ng of vitamin D increased risk of hospitalization with infection by 2.8 times – April 2016

1,000 hits for "hospital acquired infections" "vitamin D" Dec 2022

• Vitamin D Status and the Risk for Hospital-Acquired Infections in Critically Ill Adults: A Prospective Cohort Study - April , 2015 https://doi.org/10.1371/journal.pone.0122136 FREE PDF small study

• Vitamin D, Hospital-Acquired Infections and Mortality in Critically Ill Patients: Emerging Evidence - 2017 https://doi.org/10.1007/978-3-319-51908-1_15 book chapter

• An effect of single high dose of vitamin D3 on the risk of nosocomial infections, hospitalization time and mortality in hospitalized elderly population. A preliminary report - Dec 2020 https://doi.org/10.36553/wm.56

  • One dose of 60,000 IU reduced incidence of Clostridium difficile infection RCT

• Relationship Between Preoperative 25-Hydroxy Vitamin D and Surgical Site Infectiom - Jan 2020 https://doi.org/10.1016/j.jss.2019.07.036