Vitamin D might reduce Multisystem Inflammatory Syndrome in children

Created March 2021

Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C)

Front Immunol. 2021 Mar 8;12:648546. doi: 10.3389/fimmu.2021.648546

Gavriela Feketea 1 2, Vasiliki Vlacha 3, Ioana Corina Bocsan 4, Emilia Vassilopoulou 5, Luminita Aurelia Stanciu 6, Mihnea Zdrenghea 1 7

1. VitaminDWiki studies in Children and Inflammation and Virus This list is automatically updated {category} Also known as Paediatric Inflammatory Multisystem Syndrome Is apparently similar to Kawasaki disease * Kawasaki disease (strawberry tongue) associated with very low vitamin D – May 2015 --- 1. See also web * "Multisystem inflammatory syndrome in a neonate, temporally associated with prenatal exposure to SARS-CoV-2: a case report - April 1. 2021 📄 PDF * "COVID‐19 multisystem inflammatory syndrome in three teenagers with confirmed SARS‐CoV‐2 infection"- July 2020 📄 PDF

📄 Download the PDF from VitaminDWiki

image

Multisystem Inflammatory Syndrome in children (MIS-C) is a rare but devastating complication of coronavirus disease 19 (COVID-19). The development of prognostic biomarkers and more importantly the implementation of new treatment modalities would have a significant impact in clinical practice regarding the outcome of MIS-C. Vitamin D could be a potential candidate. In this mini review we analyze the immunomodulatory role of vitamin D in viral infections and specifically in COVID-19. We also examine the current literature regarding the association of vitamin D with MIS-C and Kawasaki disease. The vitamin D was evaluated not only as a biomarker but also as a nutritional supplement.

We concluded that vitamin D levels could be valuable in predicting severe forms of MIS-C and correction of abnormal levels in severe MIS-C may influences its evolution. 25-hydroxyvitamin D3 [25(OH)D3] supplementation raising serum [25(OH)D] concentrations potentially have a favorable effect in reducing the severity of MIS-C in certain circumstances. Further studies are needed to confirm these results.

Tags: Infant-Child Inflammation Virus