Short-term memory 2X better for those who took slightly more vitamin D 14 years before

Midlife Dietary Vitamin D Intake and Subsequent Performance in Different Cognitive Domains

Ann Nutr Metab 2014;65:81-89, (DOI:10.1159/000365154)

Andreeva V.A. v.andreeva@eren.smbh.univ-paris13.fr

· Whegang-Youdom S. · Touvier M. · Assmann K.E. · Fezeu L. · Hercberg S. · Galan P. · Kesse-Guyot E.

aSorbonne Paris Cité, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre d'Epidémiologie et Biostatistiques Paris Nord, Inserm U1153, Inra U1125, Cnam, Université Paris 13, Université Paris 5, Université Paris 7, and bDépartement de Santé Publique, Hôpital Avicenne, Bobigny, France

Background/Aims: We evaluated the cross-time association between midlife dietary vitamin D intake and subsequent cognitive performance in a French general-population sample. Methods: Data from participants in both the SU.VI.MAX trial (1994-2002) and the SU.VI.MAX 2 observational study (2007-2009) were used. Dietary intake was estimated at baseline from 6 or more 24-hour records. Cognitive performance was evaluated 13 years later with a comprehensive neuropsychological battery. Parameter estimates of cognitive performance according to quartiles (Q) of vitamin D intake were estimated via ANCOVA.

Results: In a sample of 1,990 aging adults, principal component analyses yielded two cognitive factors - for episodic/semantic memory and short-term memory/executive function; however, neither one displayed associations with dietary vitamin D intake. Midlife vitamin D intake was significantly and positively associated with scores on the forward digit span task measuring short-term memory (fully adjusted model: mean difference, Q4 vs. Q1 = 1.95 ; 95% CI 0.37-3.53; ptrend = 0.03). No significant interaction with either sex or lifetime sun exposure was found.

Conclusions: Midlife vitamin D intake exhibited a cross-time and domain-specific association with cognition in the context of aging. Further investigations in this area of prevention are warranted given the rapidly expanding elderly population and the absence of curative treatment for dementia.

© 2014 S. Karger AG, Basel

See also VitaminDWiki

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• Cognition declined somewhat if low vitamin D – March 2014

• Dementia 13X more likely in elderly with low vitamin D – May 2014

• Vitamin D was one of the few drugs which improved cognition in seniors – Aug 2013

• Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012

• "Senior moment" 25X more likely with low vitamin D - Feb 2012

• Visual memory improved a bit by vitamin D if start with less than 30 ng – RCT Jan 2017

• Senior cognition improved somewhat by 4,000 IU of Vitamin D (if initially less than 30 ng) – RCT April 2017

• Better memory if take lots of vitamin D (senior rats) – May 2015

• Slower cognitive decline if higher vitamin D (1500 adults, 5 years) – Feb 2018

• Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017

• Short-term memory 2X better for those who took slightly more vitamin D 14 years before – Sept 2014

  Overview Alzheimer's-Cognition and Vitamin D has the following summary

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