Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D)

Created October 2016

Pesticides: an update of human exposure and toxicity.

Arch Toxicol. 2016 Oct 8.

Mostafalou S1, Abdollahi M2,3,4. (IRAN)

Possible Mechanisms 1. Pesticides reduce Vitamin D, which increase the rate of each disease 1. Pesticides increase the rate of each disease, and Vitamin D is consumed in dealing with the inflammation, etc. See also VitaminDWiki * Risk of severe ADHD increased 2X if multiple pesticides in urine while pregnant – June 2019 * DDT and other pesticides decrease vitamin D * Interesting: DDT peak use is when the vitamin D deficiency epidemic started * Includes link to extensive Pesticide Disease Database * DDT 3.8 X more prevalent with Alzheimer disease (no mention that DDT decreases vitamin D) – Jan 2014 * Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018 * ALS fought by vitamin D - many studies ALS 5 X more likely if exposed to pesticides - JAMA May 2016 * Reasons for low response to vitamin D * If parents exposed to pesticides, genes changed. will need more vitamin D to avoid Prostate Cancer – July 2013 * Magnesium deficiency reasons – 2013 * "The use of herbicides and pesticides that kill off worms and bacteria in the soil. It is the bacteria in the soil that make it possible for plants to absorb minerals." See also web * Use of Paraquat in the US has increase by10X in past decade NYT Dec 2016 * Paraquat is associated with Parkinson's Disease . It is not permitted to be used in China, Europe, etc. * NYT includes a link to NIH report about Paraquat and PD in 2011 and a link to Meta-analysis of 2X increase in PD with pescicides/solvents * EPA is considering banning its use in the US in 2018 * * [organophosphates ](https://articles.mercola.com/sites/articles/archive/2018/11/06/organophosphate-pesticides-health-risks.aspx?utm_source=dnl&utm;_medium=email&utm;_content=art2&utm;_campaign=20181106Z1_UCM&et;_cid=DM245342&et;_rid=463114252) Mercola Nov 2018** * "A class of pesticides called organophosphates (OPs) has been implicated for the brain-destroying health risks — such as attention and memory deficits, autism and lower IQs — they present to children" * "OP compounds were originally developed in the 1930s and 1940s for use as human nerve gas agents; some were later adapted at lower doses for use as insecticides" * "To date, U.S. regulators have already banned 26 out of 40 OP pesticides considered to be human health hazards, whereas the European Union has banned 33 of 39" * "The problem is that when you have an exposure as ubiquitous as [OPs], you get distributional shifts in IQ, with fewer people in the brilliant range and more in the lower ranges of IQ. "

Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern. Regardless of acute poisonings which are common for some classes of pesticides like organophosphoruses, the association of chronic and sub-lethal exposure to pesticides with a prevalence of some persistent diseases is going to be a phenomenon to which global attention has been attracted. In this review, incidence of various malignant, neurodegenerative, respiratory, reproductive, developmental, and metabolic diseases in relation to different routes of human exposure to pesticides such as occupational, environmental, residential, parental, maternal, and paternal has been systematically criticized in different categories of pesticide toxicities like carcinogenicity, neurotoxicity, pulmonotoxicity, reproductive toxicity, developmental toxicity, and metabolic toxicity.

A huge body of evidence exists on the possible role of pesticide exposures in the elevated incidence of human diseases such as

  • cancers,

  • Alzheimer,

  • Parkinson,

  • amyotrophic lateral sclerosis,

  • asthma,

  • bronchitis,

  • infertility,

  • birth defects,

  • attention deficit hyperactivity disorder,

  • autism,

  • diabetes, and

  • obesity.

Most of the disorders are induced by insecticides and herbicides most notably organophosphorus, organochlorines, phenoxyacetic acids, and triazine compounds.

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Organophosphate exposures during pregnancy and child neurodevelopment - PLOS Oct 2018

    Recommendations for essential policy reforms

  • "In one review, adverse effects of OP pesticide exposure on neurodevelopment were seen in all but one of the 27 studies evaluated; the strongest associations occurred following prenatal exposures"

  • "Outcomes associated with OP pesticide exposure to the fetus include abnormal primitive reflexes in newborns; mental and motor delays among preschoolers; and decreases in working and visual memory, processing speed, verbal comprehension, perceptual reasoning, and IQ among elementary school–age children. Prenatal exposures also elevated risks for symptoms or diagnoses of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD)"

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Tags: ADHD Cognitive Interactions