Omega-3 benefits in surgery and ICU including via IV

Omega-3 Fatty Acids in Modern Parenteral Nutrition: A Review of the Current Evidence.

J Clin Med. 2016 Mar 7;5(3). pii: E34. doi: 10.3390/jcm5030034.

Klek S1.

Stanley Dudrick's Memorial Hospital, General Surgery Unit, Skawina 32-050, Poland. klek@poczta.onet.pl.

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Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstrating the effects of omega-3 and omega-6 polyunsaturated fatty acids (PUFA) on key metabolic functions, including

• inflammatory and

• immune response,

• coagulation, and

• cell signaling.

Indeed, emerging evidence suggests that the effects of omega-3 PUFA on inflammation and immune response result in meaningful therapeutic benefits in

• surgical,

• cancer, and

• critically ill patients as well as patients

• requiring long-term parenteral nutrition.

The present review provides an overview of the mechanisms of action through which omega-3 and omega-6 PUFA modulate the immune-inflammatory response and summarizes the current body of evidence regarding the clinical and pharmacoeconomic benefits of intravenous n-3 fatty acid-containing lipid emulsions in patients requiring parenteral nutrition.

PMID: 26959070 PMCID: PMC4810105 DOI: 10.3390/jcm5030034

Clipped from PDF

• “ . . analyzed patient outcomes and hospital economic data from Italian, French, German, and UK

hospitals using a discrete event simulation scheme and demonstrated that treatment costs were entirely

offset by reductions in antibiotic use and the length of hospital stay”