Nanoemulsions of vitamin D help reduce asthma markers in mice

Created December 2013

Pharmacological and Pharmacokinetic Studies with Vitamin D-loaded Nanoemulsions in Asthma Model.

Inflammation. 2013 Dec 11.

Wei-Hong T, Min-Chang G, Zhen X, Jie S. sunjiehuzhou@yeah.net

Taizhou Enze Medical Center Zhejiang Hospital, Zhejiang, 318050, People's Republic of China.

Vitamin D (VD) was studied for its anti-inflammatory activities with prepared VD-loaded nanoemulsions (VDNM) in ovalbumin-induced asthmatic mice in this paper.

In this study, we prepared VDNM for the delivery of VD from the established composition of solid self-emulsifying drug delivery systems (sSEDDS) by spray-drying technique and evaluated its bioavailability (BA) and anti-inflammatory activities in experimental allergic asthma. After the mice were treated orally with VD or VDNM, the plasma 25(OH) D levels, polymorphonuclear cells, tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), total antioxidant activity, and C3 and C4 complement protein levels were studied, respectively.

Treatment with VDNM reduced

  • MPO activity,

  • oxidative stress,

  • C3 protein level,

  • O2 - level as well as the

  • production of IL-1β and TNF-α.

Pharmacokinetic studies showed that a significant increase in the maximum concentration (C max) and AUC0→24 h were observed in VDNM group when compared with VD group (P < 0.01).

The result revealed that VDNM led to an improvement in oral BA of VD in a murine ovalbumin-induced asthma model. These data provided an important proof that VDNM might be a new potential therapy for the management of asthma in humans.

PMID: 24326945

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Note:

  • The nanoemulsion had a better bioavailability than standard oral vitamin D.

  • It does not indicate how much better: 2%. 20%, 200%?

  • It does not indicate if it actually helped reduce asthma

Tags: Breathing Forms