Multiple sclerosis patients have 15 ng lower levels of vitamin D – meta-analysis

Vitamin D status and the risk of multiple sclerosis: a systematic review and meta-analysis.

Neurosci Lett. 2014 Jun 6;570:108-13. doi: 10.1016/j.neulet.2014.04.021. Epub 2014 Apr 24.

Duan S1, Lv Z2, Fan X1, Wang L1, Han F1, Wang H1, Bi S3.

1Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.

2Department of Rehabilitation, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.

3Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China. Electronic address: bisheng13224510036@163.com.

To estimate the associations between vitamin D status and multiple sclerosis (MS). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'multiple sclerosis'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and MS. Eleven studies met the inclusion criteria. 1007 patients and 829 controls were included.

Results of our meta-analysis show that MS patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls (weighted mean difference[MD], -14.52 , 95% confidence interval [CI], -23.83 to -5.22). There were statistically significant heterogeneity (P<0.00001; I(2)=92%). The significant heterogeneity may be due to the differences in ethnicity, country, season of blood sampling and age of the participants studied. To sum up, low vitamin D levels are associated with an increased risk of MS.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

PMID: 24769422

See also VitaminDWiki

The articles in both MS and Meta-Analysis are:

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Overview MS and vitamin D contains the following summary

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