Less likely to die of various causes if higher Vitamin D (data from 300,000 people)
Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study
Ann Intern Med . 2022 Oct 25.doi: 10.7326/M21-3324.
Joshua P Sutherland1 joshua.sutherland@mymail.unisa.edu.au , Ang Zhou 2 , Elina Hyppönen 2 elina.hypponen@unisa.edu.au
A few of the mortality charts: All-cause, Cardio, Respiratory, Cancer (need at least 40 ng)
Background: Low vitamin D status is associated with increased mortality, but randomized trials on severely deficient participants are lacking.
Objective: To assess genetic evidence for the causal role of low vitamin D status in mortality.
Design: Nonlinear Mendelian randomization analyses.
Setting: UK Biobank, a large-scale, prospective cohort from England, Scotland, and Wales with participants recruited between March 2006 and July 2010.
Participants: 307 601 unrelated UK Biobank participants of White European ancestry (aged 37 to 73 years at recruitment) with available measurements of 25-hydroxyvitamin D (25-(OH)D) and genetic data.
Measurements: Genetically predicted 25-(OH)D was estimated using 35 confirmed variants of 25-(OH)D. All-cause and cause-specific mortality (cardiovascular disease [CVD], cancer, and respiratory) were recorded up to June 2020.
Results: There were 18 700 deaths during the 14 years of follow-up. The association of genetically predicted 25-(OH)D with all-cause mortality was L-shaped (P for nonlinearity < 0.001), and risk for death decreased steeply with increasing concentrations until 50 nmol/L. Evidence for an association was also seen in analyses of mortality from cancer, CVD, and respiratory diseases (P ≤ 0.033 for all outcomes). Odds of all-cause mortality in the genetic analysis were estimated to increase by 25% (odds ratio, 1.25 [95% CI, 1.16 to 1.35]) for participants with a measured 25-(OH)D concentration of 25 nmol/L compared with 50 nmol/L.
Limitations: Analyses were restricted to a White European population. A genetic approach is best suited to providing proof of principle on causality, whereas the strength of the association is approximate.
Conclusion: Our study supports a causal relationship between vitamin D deficiency and mortality. Additional research needs to identify strategies that meet the National Academy of Medicine's guideline of greater than 50 nmol/L and that reduce the premature risk for death associated with low vitamin D levels.
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This study underestimates the problem by about 2X by ignoring 6+ genes that reduce Vitamin D levels in blood from getting to cells
VitaminDWiki - studies in both categories Mortality and Cardiovascular
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VitaminDWiki - studies in both categories Mortality and Breathing
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VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)
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VitaminDWiki - Mortality category contains
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Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)
Differences and determinants of vitamin D deficiency among UK biobank participants: A cross-ethnic and socioeconomic study
Clinical NutritionVolume 40, Issue 5, May 2021, Pages 3436-3447 https://doi.org/10.1016/j.clnu.2020.11.019
Joshua P.Sutherland a, AngZhou a Matthew J.Leach b ElinaHyppönen ac
