Inflammatory Bowel Disease Inflammation and Vitamin D – scores of studies and trials

Created September 2019

Vitamin D in inflammatory bowel disease: from biology to clinical implications

Complementary Therapies in Medicine, https://doi.org/10.1016/j.ctim.2019.08.023

Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Seyed Mahdi Hassanian, Ali Mottaghi-Moghaddam, Anahita Ghazaghi, Maryam Ghandehari, Mohadese Alizade-Noghani, Majid Khazaei, Majid Ghayour-Mobarhan, Gordon A. Ferns, Seyed Mohammad Reza Parizadeh, Amir Avan

1. Most of the trials used 1) too little D3, 2) non gut-friendly D3, or 3) Vitamin D2 1. Overview Gut and vitamin D has the following summary {include} 1. Overview Gut and vitamin D contains gut-friendly information {include} 1. Gut category listing contains the following {include} Inflammatory Bowel Disease – proposed Vitamin D protocol – Oct 2019

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Highlights:

  • Vitamin D deficiency is a major concern in general population as well as in IBD patients.

  • The main focus of most of present clinical studies are on the inflammatory state rather than evaluation clinical outcomes.

  • The exact dose of vitamin D supplementation in IBD patients has not been studied systematically in clinical trials which requires further studies with greater sample size with more emphasizes on every vitamin D sources especially the sun exposure.

Inflammatory bowel disease (IBD) Is a chronic Immune-medlated Inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn's disease (CD). The precise etiology of IBD remains unknown. Vitamin D Is an Important mlcronutrlent that plays a critical biological role In various processes In human tissues. However, the relationship between disruption of the gut mlcroblota and the development of IBD Is unclear. Some studies suggest that IBD Is the cause of disrupted gut mlcroblota while others propose that gut mlcroblota Itself can lead to development of IBD. Regardless of this complexity, It has emerged that vitamin D Is an Immunoregulatory factor that plays a significant role In the pathogenesis of IBD by affecting the gut mlcroblome and the Inflammatory response. It has been reported that 38.1% of CD patients and 31.6% of UC patients suffer from vitamin D deficiency (VDD). In this review, we aimed to evaluate the association between VDD and IBD, summarizing recent clinical studies examining the effect of low vitamin D and the role of vitamin D supplementation on IBD clinical outcomes.

Tags: Gut