Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females)

Created May 2019

Sex-specific role of CYP24A1 rs2762939 in the risk of essential hypertension based on the serum vitamin D and total renin concentrations

Genomics, 16 May 2019, https://doi.org/10.1016/j.ygeno.2019.05.013

lVarsha Varakanthama Kiranmayee Alea Ashok Kumar Kurakula Sailoob Balakrishna Nagallac Dinesh Kumar Bharatraja

CYP24A1 normally breaks down excess Vitamin D in the body CYP24A1 mutation can allow the accumulation of Vitamin D in the body Excess Vitamin D can result in Calcium problems if Magnesium or water are not increased     Note: A Vit D test will not detect this problem * High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019 * Hypertension gene expression reduced by high-dose vitamin D (hypertensive rats) – March 2019 --- 1. Genetics category listing contains the following {include} --- Search VitaminDWiki for CYP24A1 1150 items as of May 2019 * Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems – June 2018 * Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014 * CYP24A1 mutation caused more Vitamin D to stay in the body ==> fighting Breast Cancer * Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012 * [CLICK HERE](http://www.google.com/custom?hl=en&client;=google-coop&cof;=FORID:13%3BAH:left%3BCX:Search%2520Vitamin%2520D%2520Wiki%3BL:http://www.google.com/intl/en/images/logos/custom_search_logo_sm.gif%3BLH:30%3BLP:1%3BVLC:%23551a8b%3BDIV:%23cccccc%3B&cx;=001215644404345293668:3di8vufs_m4&adkw;=AELymgXNaxh6db7gm6Ov75xkjRPcf0ojNY8S9b-oIawLTdQFg79ch6AkKiXJ9Gs7uspXzg_8z1uNRxWGcd3csmAplyuOkquHZYgHfTcd7lmPv4ZIOsI0XIs&boostcse;=0&ei;=6r_fTerABcfbiALjwM3lCg&q;=CYP24A1&start;=0&sa;=N) to use Google to find **CYP24A1 in VitaminDWiki - 1350 hits as of May 2019 * [ CYP24A1 * gene mutation is a cause of some infant vitamin D toxicity – Aug 2011](/pages/cyp24a1-gene-mutation-is-a-cause-of-rare-infant-vitamin-d-toxicity/) NEJM

Highlights

  • Risk of essential hypertension was found to be sex-dependent in the carriers of CC genotype of CYP24A1 rs2762939.

  • In the CC carriers of CYP24A1 rs2762939, females demonstrated a protective role whereas males had higher risk in the genetic predisposition to EH.

  • The levels of 25-hydroxy Vitamin D and total renin concentrations may explain this contrasting risk posed by the CYP24A1 rs2762939 CC variant.

CYP24A1, Vitamin D 24-hydroxylase catabolizes 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D to 24-hydroxylated vitamin D products. It is widely known that low Vitamin D can lead to increased renal renin and angiotensin II production, consequently elevating blood pressure or development of essential hypertension (EH). We have conducted an investigation on hypertensives and controls to evaluate the association of the gene variant, CYP24A1 rs2762939 and 25(OH)D in an Indian population with EH. On gender-based stratification, with multivariate logistic analysis after adjustment for covariates, the CYP24A1 rs2762939 CC variant showed a higher risk of EH in males (aOR = 3.141 , CI 1.164–8.478, P = .024) while females illustrated an inverse association with EH ( aOR = 0.398 , CI 0.172–0.092, P = .031). The 25(OH)D levels among the three genotypes of hypertensives substantiate these results. Our results clearly suggest that gender, CYP24A1 rs2762939, and Vitamin D status may play a significant role in disease susceptibility towards EH in Indian population.

Tags: Genetics Hypertension