Gut problems associated with low vitamin D – invited review

Vitamin D deficiency in patients with intestinal malabsorption syndromes – think in and outside the gut (invited review)

Journal of Digestive Diseases, Volume 16, Issue 11, pages 617–633, November 2015

Article first published online: 29 DEC 2015, DOI: 10.1111/1751-2980.12283

Samantha L Margulies1, Divya Kurian1, Mark S Elliott2 andZhiyong Han2,*

© 2015 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd

There is a very high prevalence of vitamin D deficiency, which is defined by a serum level of 25-hydroxyvitamin D [25(OH)D] of lower than 20 ng/mL, in all populations of the world. Unfortunately, the prevalence of vitamin D deficiency in patients with intestinal malabsorption syndromes, including

• cystic fibrosis (CF),

• celiac disease (CD),

• short bowel syndrome and

• inflammatory bowel disease (IBD),

is higher than that in the general population, indicating the presence of disease-specific causative factors. In this review, we aimed to present clinical findings to highlight the roles of insufficient exposure to sunlight and inflammation in the development of vitamin D deficiency in patients with intestinal malabsorption syndromes. Furthermore, we aimed to present experimental evidence that supported a role of vitamin D deficiency in the pathogenesis of IBD.

Finally, we reviewed clinical intervention strategies aiming to normalize vitamin D status in and even to improve the conditions of patients and to discuss certain issues that needed to be addressed in future research.

One table from the study

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Study was rented for $6 by VitaminDWiki

• They notice that those with gut problems have poor time getting vitamin D in thru he gut

• They mention that UV and sublingual might be good ways to get vitamin D

• Little mention of genes

• They seem to not mention many other forms such as topical, spray, injection, and gut-friendly

See also VitaminDWiki

• Overview Gut and vitamin D

• Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015

• IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015

  The Meta-analysis of Gut and Vitamin D

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All items in categories Intervention AND Gut

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Many ways to increase Vitamin D

click on chart for details