Following Digestive Cancer 2,000 IU of Vitamin D were given. Those whose Omega-3 levels rose had fewer Cancer problems – RCT

Interaction of Vitamin D Supplements and Marine n-3 Fatty Acids on Digestive Tract Cancer Prognosis

Cancer Prognosis. Nutrients 2024,16,921. https://doi.org/10.3390/nul6070921

Soichiro Fukuzato ©, Hironori Ohdaira 2, Yutaka Suzuki 2 and Mitsuyoshi Urashima 1,

Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo 105-8461, Japan; sunshine1.324@jikei.ac.jp

Department of Surgery, International University of Health and Welfare Hospital, Narita-shi 286-0048, Japan; ohdaira@iuhw.ac.jp (H.O.); yutaka@iuhw.ac.jp (Y.S.)

A meta-analysis suggested that marine n-3 polyunsaturated fatty acids (PUFAs), e.g., eicos- apentaenoic acid (EPA) and docosahexaenoic acid (DHA), might reduce cancer mortality. However, a randomized clinical trial of marine n-3 PUFA and vitamin D supplementation failed to verify this benefit. This study aimed to investigate the potential interaction between vitamin D supplementation and serum EPA and DHA levels. This post hoc analysis of the AMATERASU trial (UMIN000001977), a randomized controlled trial (RCT), included 302 patients with digestive tract cancers divided into two subgroups stratified by median serum levels of EPA + DHA into higher and lower halves. The 5-year relapse-free survival (RFS) rate was significantly higher in the higher half (80.9%) than the lower half (67.8%; hazard ratio (HR), 2.15; 95% CI, 1.29-3.59). In the patients in the lower EPA + DHA group, the 5-year RFS was significantly higher in the vitamin D (74.9%) than the placebo group (49.9%; HR, 0.43; 95% CI, 0.24-0.78). Conversely, vitamin D had no effect in the higher half, suggesting that vitamin D supplementation only had a significant interactive effect on RFS in the lower half (p for interaction = 0.03). These results suggest that vitamin D supplementation may reduce the risk of relapse or death by interacting with marine n-3 PUFAs.

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I do not recall ever seeing Omega-3 levels rise due to Vitamin D

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Perhaps vitamin D calmed the digestive system enough that more Omega-3 in food got into the body

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Speculate: Similar reduction in Digestive Cancer problems after surgery if supplement Omega-3 in addition to Vitamin D

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5 related items in VitaminDWiki

1. Gastric Cancer, Vitamin D, VDR, UV - many studies

2. Digestive Tract Cancer survival increased 3X if 2,000 IU of vitamin D and have high level of PD-L1 – RCT June 2021

3. Gastrointestinal Cancers - mostly positive Vitamin D studies – May 2019

4. Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT Sept 2018

5. People taking Vitamin D far more likely to be disease free after esophageal cancer surgery – Dec 2016

6. Omega-3 increases Vitamin D levels – Meta-analysis May 2022 - opposate of what current trial found

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18+ VitaminDWiki Omega-3 pages have CANCER in the title

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139+ VitaminDWiki Omega-3 pages have VITAMIN in the title

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6+ VitaminDWiki pages have DIGESTIVE and CANCER in the title

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