Diabetes treated by vitamin D when levels exceeded 61 ng

The Effect of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes Mellitus

Journal of the American College of Nutrition, online Sept 2015, DOI:10.1080/07315724.2015.1026427

Magda I. Mohamad MD ab*, Enas E. El-Sherbeny MD ab & Meram M. Bekhet Md ab

a Medical Biochemistry Department (M.I.M.), Endocrinology Department (M.M.B.), Faculty of Medicine, Ain Shams University, Cairo, EGYPT

b Public Health & Community Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, EGYPT (E.E.E.-S.)

Summary by VitaminDWiki

Aim: The aim of this study was to evaluate the effect of vitamin D supplementation in patients with type 2 diabetes mellitus (T2DM) with regard to their glycemic control and lipid profile.

Methods: One hundred subjects with diabetes were recruited and given 4500 IU/day of vitamin D for 2 months. 25-Hydroxyvitamin D [25(OH)D], fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), and lipid profile were measured pre- and postsupplementation.

Results: There was a significant increase in the mean value of 25(OH)D level after supplementation (baseline level 16 ± 5.3 ng/ml vs. after supplement level 49.2 ± 17.7 ng/ml, p < 0.05). Both FBG and HbA1c but not lipid profile were significantly decreased after supplementation. However, the univariate general linear model between 25(OH)D percentiles and lipid profile levels showed that subjects with diabetes with high 25(OH)D levels (>61 ng/ml) had significantly lower levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C) in comparison to those in the low or middle percentiles. Furthermore, participants in a higher percentile had a significantly higher level of high-density lipoprotein cholesterol (HDL-C) than those in the middle percentile. Lipid profile levels were not affected by the supplement except for triglycerides (TG) levels in females, which were significantly decreased.

Conclusions: Vitamin D supplementation may be beneficial to subjects with diabetes because it improved glycemic control. Subjects with diabetes with high 25(OH)D levels (>61 ng/ml) had better lipid profiles.

PDF is available free at Sci-Hub   10.1080/07315724.2015.1026427

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