Diabetes risk increased by 50 percent if had 5 courses of antibiotics

Created September 2015

Use of Antibiotics and Risk of Type 2 Diabetes: A Population-Based Case-Control Study

Kristian Hallundbæk Mikkelsen kristianmikkel@gmail.com, Filip Krag Knop, Morten Frost, Jesper Hallas, and Anton Pottegård

JCEM online first DOI: http://dx.doi.org/10.1210/jc.2015-2696

The research on antibiotics and increased incidence of obesity has found that a 5 X increase in incidence of obesity from antibiotics in first 6 months of life. Suspect that if the data of this study were to be re-analyzed for antibiotic courses in just infants that an even larger effect would be found. See also VitaminDWiki * Antibiotics, probiotics **category listing has items along with related searches** * Antibiotics and Vitamin D are associated with many of the same diseases * antibiotics use in first 6 month increases obesity by 5X (linked above) * Antibiotic increased risk of diabetes (Vitamin D might help) - several studies * Antibiotic usage US map is very similar to obesity US map - June 2015 * perhaps diabetes map would also match * Prediabetic have very different gut bacteria – March 2015 * 1.8X increased risk of Obesity if antibiotics were used during pregnancy – Nov 2014 See also New York Times review of the study

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Context and objective:

Evidence that bacteria in the human gut may influence nutrient metabolism is accumulating. We investigated whether use of antibiotics influences the risk of developing type 2 diabetes and whether the effect can be attributed to specific types of antibiotics.

Methods:

We conducted a population-based case-control study of incident type 2 diabetes cases in Denmark (population 5.6 million) between January 1, 2000, and December 31, 2012. Data from the Danish National Registry of Patients, the Danish National Prescription Registry, and the Danish Person Registry were combined.

Results:

The odds ratio (OR) associating type 2 diabetes with exposure to antibiotics of any type was 1.53 (95% confidence interval 1.50–1.55) with redemption of more than or equal to 5 versus 0–1 prescriptions. Although no individual group of antibiotics was specifically associated with type 2 diabetes risk, slightly higher ORs for type 2 diabetes were seen with narrow-spectrum and bactericidal antibiotics (OR 1.55 and 1.48) compared to broad-spectrum and bacteriostatic types of antibiotics (OR 1.31 and 1.39), respectively. A clear dose-response effect was seen with increasing cumulative load of antibiotics. The increased use of antibiotics in patients with type 2 diabetes was found up to 15 years before diagnosis of type 2 diabetes as well as after the diagnosis.

Conclusions:

Our results could support the possibility that antibiotics exposure increases type 2 diabetes risk. However, the findings may also represent an increased demand for antibiotics from increased risk of infections in patients with yet-undiagnosed diabetes.