Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall)
A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community
J Alzheimers Dis. 2021 Nov 18. doi: 10.3233/JAD-215011
Jeanne Neuffer 1, Marjorie Gourru 1, Aline Thomas 1, Sophie Lefèvre-Arbogast 1, Alexandra Foubert-Samier 2, Catherine Helmer 1, Cécile Delcourt 1, Catherine Féart 1, Cécilia Samieri 1
Background: Low blood status in several nutritional compounds, including long-chain omega-3 fatty acids (LC n-3 PUFA), carotenoids, and vitamin D, have been associated with a higher risk to develop dementia. Nutritional deficiencies may potentiate each other regarding dementia risk; yet the association of multiple nutritional deficiencies with dementia has been little explored.
Objective: To develop an index of micronutritional biological status (MNBS) for the screening of multi-micronutritional deficiencies associated with the risk of dementia in a prospective population-based cohort of older persons.
Methods: We included participants from the Bordeaux Three-City study, who were free of dementia at baseline, had blood measurements of LC n-3 PUFA, carotenoids, and 25(OH)D, and who were followed for up to 18 years for dementia. We used penalized splines in Cox models to model dose-response relationships of each nutritional component with the risk of dementia and construct a risk index.
Results: 629 participants with an average age of 73.1 years were included in the study. Each increase of 1 SD of the MNBS index was associated with a 46%higher risk of dementia (HR = 1.46, 95%CI 1.23; 1.73). Participants with highest index ([mean+1SD; max]) had a 4-fold increased risk of dementia compared with participants with a low index ([min; mean-1SD]) (HR = 4.17, 95%CI 2.30; 7.57).
Conclusion: This index of assessment of micronutritional biological status is a practical tool that may help identify populations with inadequate nutritional status, screen eligible individuals for nutritional prevention in primary care, or for supplementation in preventive trials of dementia.
VitaminDWiki - Cognition and Vitamin D - a few studies
Genes restrict vitamin D from getting to brain cells
8 genes associated with both Alzheimer’s and lowish Vitamin D – May 2019
2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021
Getting Vitamin D reduces or halt cognitive decline
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019
Cognitive function of adult women improved in 3 months of 50,000 IU weekly Vitamin D – Jan 2019
VitaminDWiki - Cognitive and Omega-3 studies
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VitaminDWiki - Alzheimers-Cognition - Overview starts with
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VitaminDWiki - Overview Schizophrenia and Vitamin D starts with
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VitaminDWiki pages with DEMENTIA in title (40 as of May 2022)
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