Colon Cancer helped by modest Vitamin D (more needed)

Can Vitamin D Supplementation Improve Progression-Free, Relapse-Free Survival in Gastrointestinal Cancers? Oncology Nurse Advisor

* Twice as likely to survive Colorectal Cancer if had good level of Vitamin D Binding Protein – July 2019 * Vitamin D does not treat colon cancer (when you only use 1,000 IU) – RCT April 2019 * Advanced Colorectal Cancer survival is increased somewhat with 4,000 IU of vitamin D – RCT April 2019 * Digestive tract cancer death rates reduced a bit by a bit of vitamin D – RCT April 2019 * Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018 * Overview Cancer-Colon and vitamin D * Chemotheraphy not work as well with low Vitamin D (colon cancer this time) – Aug 2018 * Colon Cancer survival increased by MEG3 (MEG3 is increased by Vitamin D in lab) – 2018 * High level of MEG3 (a gene) helps a lot *

SUNSHINE Randomized Clinical Trial compared the effect of high-dose vs standard-dose vitamin D3 supplementation on progression-free survival (PFS) among patients with advanced or metastatic colorectal cancer

• Lots of Chemotherapy

• Started with 8,000 IU daily for 2 weeks then maintenance of 4,000 IU daily

• 35 ng average at trial end

• greater effect on survival if lower body mass index, more metastases, and KRAS wild-type tumors.

  • Needed more to get most people about 35 ng level, not just half

  • Also anticipate better survival if use larger loading dose ASAP

  • A typical loading dose protocol gives 400,000 IU in one week. This study used 112,000 IU in 2 weeks

AMATERASU Randomized Clinical Trial investigated the effect of vitamin D supplementation on relapse-free survival (RFS) among patients with digestive tract cancers.

• stage I-III digestive tract epithelial carcinoma after surgical resection from the esophagus, stomach, small intestine, colon, or rectum.

• 2,000 IU daily did not help, not a news item