Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT

Created May 2018

Vitamin D supplementation does not improve CVD risk factors in vitamin D insufficient subjects.

Endocr Connect. 2018 May 15. pii: EC-18-0144. doi: 10.1530/EC-18-0144. [Epub ahead of print]

Kubiak JM1, Thorsby PM2, Kamycheva E3, Jorde R4.

Study supplemented those with low vitamin D with 20,000 IU weekly for just 4 months     20,000 IU weekly = 2,900 IU daily Many studies are recommending that everyone needs at least 4,000 IU daily for health --- 1. See also VitaminDWiki * Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017 * Chronic Heart Failure reduced by 4,000 IU daily for a year – RCT April 2016 * Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT Jan 2015 * 1700 IU vitamin D for a year provided no cardiovascular benefit (no surprise) – RCT Oct 2014 * Major heart problems if have less than 15 ng of Vitamin D – Nov 2015 * Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017 Trial lasted for 12 months, not 4 months * Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015 * Trial lasted for 12 months, not 4 months * 3000 IU reduced hypertension for the vitamin D insufficient – RCT Aug 2012 * Trial lasted for 5 months * Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017 --- Cardiovascular category starts with the following {include} --- Overview Diabetes and vitamin D contains the following summary {include} --- Diabetes category starts with the following {include} --- Hypertension category listing contains the following {include}

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OBJECTIVE:

Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects.

DESIGN: Double-blinded randomized controlled trial.

METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of:

  • blood pressure,

  • lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B ), and

  • glucose metabolism parameters

    • (blood glucose,HbA1c, sRAGE (minor improvement), insulin, C-peptide, and HOMA-IR).

RESULTS:

422 subjects with mean serum 25(OH)D level 34 nmol/L were included, with 411 subjects completing the study. Serum 25(OH)D levels increased with 56 nmol/L and decreased with 4 nmol/L in the vitamin D and placebo group, respectively. We found no statistically significant differences between the two groups in any of the measured CVD risk factors, except for a minor increase in sRAGE in the vitamin D group.

Stratified analyses of subjects with low baseline serum 25(OH)D levels alone, or combined with blood pressure, lipid and HOMA-IR values above the median for the cohort, did not skew the results in favour of vitamin D supplementation.

CONCLUSION: Supplementation with vitamin D in subjects with baseline vitamin D insufficiency does not improve CVD risk factors profile.

PMID: 29764903 DOI: 10.1530/EC-18-0144

Tags: Cardiovascular Intervention Intervention - non daily