2.8X more likely to die of hemodialysis if low on vitamin D
Vitamin D Deficiency, Mortality, and Hospitalization in Hemodialysis Patients with or without Protein-Energy Wasting.- 2011
Nephron Clin Pract. 2011 Aug 11;119(3):c220-c226.
Fiedler R, Dorligjav O, Seibert E, Ulrich C, Markau S, Girndt M.
Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany.
Background:Vitamin D deficiency and protein-energy wasting (PEW) are highly prevalent in hemodialysis (HD) patients. The goal of our study was to investigate if a lack of vitamin D influences mortality and hospitalization of HD patients with or without PEW. Methods: In 81 chronic HD patients with different nutritional status assessed by the Malnutrition Inflammation Score (MIS), vitamin D deficiency (25-OH-vitamin D(3) levels ?30 nmol/l or ?12 ng/ml ) was prospectively investigated for its prognostic impact on mortality and hospitalization. Over a 3-year follow-up, all-cause mortality and hospitalization were determined. The predictive value of low vitamin D levels and PEW as well as their combined effect were evaluated using a multivariate Cox regression model.
Results: Vitamin D deficiency was frequent in HD patients with and without PEW. It significantly increased mortality rate in HD patients ( HR 2.76 (1.33-5.73), p < 0.01), which was aggravated by concomitant PEW (HR 5.88 (2.29-15.09), p < 0.001). The hospitalization rate, however, was not influenced independently by nutritional status.
Conclusions: Low 25-OH-vitamin D(3) concentration is an independent predictor for survival, but not for hospitalization of HD patients. It is not merely a malnutrition-associated finding, although a MIS ?8 further impaired survival prognosis.
Vitamin D status and mortality of German hemodialysis patients.- 2012
Anticancer Res. 2012 Jan ;32(1):391-5.
Krause R, Schober-Halstenberg HJ, Edenharter G, Haas K, Roth HJ, Frei U.
KfH Nephrological Center Moabit, Turmstr. 20A, 10559 Berlin, Germany. rolfdieter.krause@kfh-dialyse.de
AIM: The goal was to analyze the link between blood levels of calcidiol and all-cause, cardiac and infectious diseases, and mortality due to cancer in hemodialysis patients.
PATIENTS AND METHODS: This study retrospectively evaluated a representative sub-cohort (n=6,518) of German hemodialysis patients from the incidence cohorts 1997-2006.
RESULTS: Most (58.8%) were found to be vitamin D deficient (25(OH)D<20 ng/ml), with 41.2% being severely deficient (25(OH)D<12.5 ng/ml). All-cause mortality risk more than doubled in patients with severe deficiency (adjusted odds ratio (aOR)=2.67; 95% confidence interval (CI)=2.30-3.10; p<0.0001). Comparable data were obtained for mortality from cardiac disease (aOR=1.57; 95% CI=1.30-1.88; p<0.0001), infectious disease (aOR=1.48; 95% CI=1.15-1.90; p=0.0026), and cancer (aOR=1.51; 95% CI=1.09-2.08; p=0.0121), respectively.
CONCLUSION: These data highlight the need to ensure primarily adequate 25(OH)D levels in dialysis patients for an advantage of survival.
See also VitaminDWiki
Even with vitamin D supplementation Kidney transplant patients were deficient – Jan 2011
Adding Vitamin decreased kidney deaths by 4x – Dec 2010
It is amazing that such excellent results were buried in the paper. They were not in the title nor abstract.
This is the result of about 10 trials with about 5,000 kidney disease patients.
Note: some of the trials were terminated as they felt it morally wrong to not give vitamin D to all of the Kidney patients
Of 908 dialysis patients: vitamin D deficiency: black women (from 90% to 100%), black men (from 85% to 100%)
Heart problems 5X worse for chronic kidney patients low on vitamin D – Mar 2011
- CKD patients 40% more likely to die of cardiovasular problems for every 10ng decrease in vitamin D
Each 10 ng increase in vitamin D decreased kidney disease death by 14 percent – May 2011 - Meta-analysis
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