Intralesional Vitamin D3 Injection in the Treatment of Recalcitrant Warts: A Novel Proposition.
J Cutan Med Surg. 2017 Apr 1:1203475417704180. doi: 10.1177/1203475417704180. [Epub ahead of print]
Raghukumar S1, Ravikumar BC1, Vinay KN1, Suresh MR1, Aggarwal A1, Yashovardhana DP1.
1 Department of Dermatology, Hassan Institute of Medical Sciences, Hassan, Karnataka state, India.
- The study only tried to treat “recalcitrant warts” = not treated by conventional means
- Appears that the study used a an average of 3.7 injections of 8,000 to 40,000 IU per recalcitrant wart
- After 6 months 90% of the previous recalcitrant warts were totally gone and 7% per partially gone
- 100% of “distant” warts were removed
- Herpes virus infection while pregnant increases Autism risk by 2 X (Vitamin D not mentioned) – Feb 2017
VitaminDwiki suspects that topical Vitamin D will also treat warts. Wife has just started topical vitamin D oil applied daily to a 20 year wart on her finger
See also web
- Wart Wikipedia
" Warts are typically small, rough, and hard growths that are similar in color to the rest of the skin”
“Warts are caused by infection with a type of human papillomavirus (HPV)”
“The estimated current rate of non-genital warts among the general population is 1–13%”
- How To Treat Recalcitrant Plantar Warts 2013
“The treatment of warts can be very challenging.”
“ Many warts fail to respond to conventional treatment and after several months are considered recalcitrant.”
“Warts (verrucae) involve the epithelium of the skin and are caused by infection with the human papillomavirus (HPV). Warts are the most common viral infection of the skin, affecting 7 to 10 percent of the general population.”
- Close to Half of American Adults Infected With HPV, Survey Finds New York Times, April 2017
Download the PDF with nice charts from VitaminDWiki
- Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions? ResarchGate, PDF online
- Association Between Serum 25-Hydroxyvitamin D Level and Human Papillomavirus Cervicovaginal Infection in Women in the United States June 2016
Verruca vulgaris (viral warts) is a fairly common condition with a plethora of treatment options having variable success rates. Recalcitrant warts are refractory to treatment with often disappointing response and high recurrence rates. Lately, treatment with intralesional injections has gained momentum due to its effectiveness in clearing warts by stimulating the cell-mediated immunity. Vitamin D, when applied topically, regulates epidermal cell proliferation and is involved in the formation of antimicrobial peptides. We have attempted to use vitamin D3 to exploit its reported action as an immunotherapeutic molecule in addition to its topical effects. To our knowledge, there are no reports of intralesional vitamin D3 injections used in the treatment of extragenital recalcitrant warts.
Sixty-four patients with recalcitrant warts of varying sizes and duration were included in the study. About 0.2- to 0.5-mL vitamin D3 solution (600,000 IU, 15 mg/mL) was injected to the base of the wart. A maximum of 5 warts were injected per session at 3-week intervals until resolution or for a maximum of 4 treatments. Patients were followed up for 6 months after the last injection to detect any recurrence.
Sixty patients completed the study. Complete response was seen in 54 of 60 (90%), partial response in 4 of 60 (6.66%), and no response in 2 of 60 (3.33%). The average number of injections required to achieve a complete resolution was 3.66. Complete resolution of distant warts was noticed in all patients.
Intralesional vitamin D3 is a safe, effective, and an inexpensive treatment option for recalcitrant warts.
PMID: 28384048 DOI: 10.1177/1203475417704180