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Vitamin K2 substantially reduces risk of T2 Diabetes (7 percent for every 10 ug) – review Nov 2017

Effect of Vitamin K2 on Type 2 Diabetes Mellitus: A Review

Diabetes Research and Clinical Practice, DOI: http://dx.doi.org/10.1016/j.diabres.2017.11.020
Yan Li Yan Li, Jie peng Chen, Jie peng Chen, Lili Duan, Shuzhuang Li, Shuzhuang L, Shuzhuang Li

 Download the Accepted Manuscript PDF from SciHub via VitaminDWiki

Studies showed vitamin K2 intake reduced 7% T2DM risk with each 10-μg increment.
•Vitamin K2 has a more significant effect than vitamin K1 on T2DM.
•Vitamin K2 increased insulin sensitivity via osteocalcin metabolism.
•Vitamin K2 improved IR via anti-inflammatory property and lipid-lowering effects.
•Vitamin K2 suppresses inflammation via inactivating NF-κB signalling pathway.
•Vitamin K2 supplementation decreases fat accumulation and serum triglycerides.

Type 2 diabetes mellitus (T2DM) continue to be a major public health problem around the world that frequently presents with microvascular and macrovascular complications. Individuals with T2DM are not only suffering from significant emotional and physical misery, but also at increased risk of dying from severe complications. In recent years, evidence from prospective observational studies and clinical trials has shown T2DM risk reduction with vitamin K2 supplementation. We thus did an overview of currently available studies to assess the effect of vitamin K2 supplementation on insulin sensitivity, glycaemic control and reviewed the underlying mechanisms. We proposed that vitamin K2 improved insulin sensitivity through involvement of vitamin K-dependent-protein osteocalcin, anti-inflammatory properties, and lipid-lowering effects. Vitamin K2 had a better effect than vitamin K1 on T2DM. The interpretation of this review will increase comprehension of the development of a therapeutic strategy to prevent and treat T2DM.


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8851 K2 diabetes 2010.jpg admin 02 Dec, 2017 17:22 13.85 Kb 29
8850 Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes.pdf admin 02 Dec, 2017 17:22 135.82 Kb 9
8849 Osteocalcin.jpg admin 02 Dec, 2017 14:50 25.72 Kb 35
8848 K2 Diabetes 1.jpg admin 02 Dec, 2017 14:37 47.59 Kb 34
8847 K2 Diabetes SciHub.pdf admin 02 Dec, 2017 14:36 1.44 Mb 14
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