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Vitamin D math mistakes made 7 years ago – K Baggerly 2016-2017

12 minute video, Nov 2016 @ American Public Health Association

Keith Baggerly is a Biostatistician, tenured professor and son of Carole Baggerly
kabagg at mdanderson.org

Mistake #1: % of cadavers with poor bones with 20-30 ng of vitamin D

They computed the ratio of bad bones with 20-30 ng vs all cadavers, rather than just those with 20-30 ng
If they had used the correct denominator the result would have been 28-30 ng, not 20 ng
Image

Mistake #2: Not having enough data to conclude that >4,000 IU is too much (i.e. harm)

Chart did not have any error bars
Image

This next chart shows the tiny differences
Image

Two more mistakes

3) Institute of Medicine used data only for bone health, but the rest of the body needs higher levels
4) incorrectly estimated dose needed to get 97.5 % of population to a vitamin D level

His previously published study of the problem
 Download the PDF from VitaminDWiki


Sharing Scientific Data and Replicability, Keith Baggerly 45 minute video, March 2017

|Arthur M. Sackler Colloquia, Published on Mar 22, 2017
This talk was given by Keith Baggerly, MD Anderson Cancer Center as part of the National Academy of Sciences Arthur M. Sackler Colloquium on Reproducibility of Research: Issues and Proposed Remedies held in Washington, D.C. on March 8-10, 2017
Note: A Parathyroid Hormone analysis of 2016-2017 independently found that a vitamin D level of 31 ng is needed
Note: 97.5% of the population = 2 sigma of an ideal bell curve distribution (the actual distribution is a very distorted bell curve)

3,000 IU is needed to get 97.5% of the population to 30ng

Note: 3,000 IU daily ==> 42,000 IU every two weeks. which is very close to the 50,000 IU proposed by VitaminDWiki 3 years before
3,000 IU is 5X more than the 600 IU erroneous conclusion of the Institute of Medicine in 2010
Image

Pregnant women in East Africa have vitamin D levels of about 60 ng

Yellow = pregnant women
Image

Baggerly's are hoping to get signicant progress on correcting the error by the end of Sept 2017


See also VitaminDWiki

IoM error  8% not just 1% see http://is.gd/iomerror8


Note: Even if you have a good blood level of vitamin D,
    poor genes, low Magnesium, low Omega-3, etc restrict how much vitamin D actually gets to your cells

Vitamin D Receptor 160 studies found incidence of 16 health problems increased by at least 3X (as of Aug 2017)
Genetics category listing contains the following

209 articles in Genetics the category

 

see also 190 articles in Vitamin D Receptor, 81 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 37+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are poor
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Additional information on the Genes in VitaminDWiki

Gene# of pages
Oct 2017
Location
CPY27A1223 Liver
CYP2R1 626Tissue
Vitamin D Binding Protein 3,450 Blood
CYP27B1803Kidney & Tissue
Vitamin D Receptor 6,030Cell Tissue
CYP24A1 745 excrete excess


short URL = https://is.gd/VitDMath

Created by admin. Last Modification: Thursday August 10, 2017 17:50:28 UTC by admin. (Version 36)

Attached files

ID Name Comment Uploaded Size Downloads
8286 East Africa pregnant women.jpg admin 09 Aug, 2017 11:52 25.62 Kb 81
8283 3,000 IU needed.jpg admin 09 Aug, 2017 11:26 31.57 Kb 88
8282 Problems With the Serum RDA KB.pdf PDF 2016 admin 08 Aug, 2017 19:06 369.35 Kb 25
8281 KB3.JPG admin 08 Aug, 2017 19:05 39.59 Kb 88
8280 KB2.JPG admin 08 Aug, 2017 19:05 55.72 Kb 91
8279 KB1.JPG admin 08 Aug, 2017 19:05 53.70 Kb 103
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