Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017

See also similar studies at the bottom of this page

Guesses of Vitamin D response if poor gut

10 Sun/UV
10Topical (skin patch/cream, vagina)
9?Inhaled (future)
8Bio-D-Mulsion Forte
6Water soluble (Bio-Tech)
5Liposomal (expensive)
4Sublinqual/spray (some goes into gut)
3Coconut oil based
2Food (salmon etc.)
2Olive oil based (majority)

10= best, 0 = worst, guesses have a range of +-2

Poor gut is associated with Gut diseases as well as Diabetes, Multiple Sclerosis, and many other diseases
Reminder - Vitamin D is absorbed in the first portion of the small intestine
Some gut problems which only occur in large intestine may not be a problem
On-going research at VitaminDWiki as of March 2017
  Getting Vitamin D into your body has details on each thype of vitamin D and the following chart

Parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with type 2 diabetes mellitus

Diabetes & Metabolic Syndrome: Clinical Research & Reviews. online 6 March 2017, http://dx.doi.org/10.1016/j.dsx.2017.03.019
Awanindra Dwivedia, Balram Guptaa, Shalbha Tiwaria, d, Daliparthy D. Pratyusha, d, Saurabh Singhc, Surya Kumar Singha, sksendocrine at yahoo.com

Oral vitamin D supplementation is better than parenteral in improving vitamin D deficiency in individuals with no systemic illness. Our aim was to compare the efficacy of oral and parenteral routes of vitamin D supplementation on circulating serum 25(OH) vitamin D level in patients with type 2 diabetes mellitus.

Total 85 cases of with type 2 diabetes mellitus were screened for vitamin D status of which 71 patients were vitamin D insufficient/deficient. They were randomized into two intent to treat groups with different vitamin D supplementation protocols

  • (a) Oral-60000 IU per day for 5 days (group I; n = 40) and
  • (b) injectable-300000 IU intramuscularly once (group II; n = 31).

Baseline and one month post supplementation 25(OH) vitamin D levels were measured in both the groups.

Baseline clinical characteristics and 25(OH) vitamin D levels were comparable in both the groups. Post treatment 25(OH) vitamin D level in

  • group I was 26.06 ± 9.06 ng/ml and in
  • group II was 49.69 ± 18.92 ng/ml.

After one month of vitamin D supplementation, increment in 25(OH) vitamin D level from baseline was significantly higher in group II than group I (p < 0.001).

Interpretation & conclusions
Injectable method of supplementation was better than oral route in improving serum 25 (OH) vitamin D status in patients with type 2 diabetes. The study suggested impaired absorption of vitamin D from the gastrointestinal tract in patients with type 2 diabetes mellitus and a need for parenteral route of vitamin D supplementation in deficient patients with type 2 diabetes mellitus.

Publisher wants $31.50 for the PDF
Purchased by VitaminDWiki

Injection references in the study

Bone Mineral Density - oral vs injection -Oct 2015


  • Full text online. 10 weeks of 60,000 IU vs 1 600,000 IU injection + daily 1 gram of Calcium
    "Although, with intramuscular route the serum vitamin D levels are maintained for 12 months, there is no improvement in BMD byeither route."
    Sufficiency (> 30 ng) at 12 month:s 85.7% injection, 22.9%. oral
Created by admin. Last Modification: Wednesday March 22, 2017 23:41:37 UTC by admin. (Version 31)

Attached files

ID Name Comment Uploaded Size Downloads
7835 BMD inection.jpg admin 15 Mar, 2017 12:40 52.53 Kb 49
7834 Injection RCT 2013.pdf PDF admin 15 Mar, 2017 12:18 270.75 Kb 60
7833 Injection rickets 2014.pdf PDF 2014 admin 15 Mar, 2017 12:00 205.30 Kb 31
7832 Rickets Injection 2014.jpg admin 15 Mar, 2017 11:54 39.52 Kb 49
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