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Vitamin D helped cardiovascular patients in many ways– Nov 2011

Vitamin D Deficiency and Supplementation and Relation to Cardiovascular Health

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Summary by VitaminDWiki:

11,000 cardiology patients in Kansas (2004-2009) were allowed to take any amount of vitamin D they wanted
They were analyzed as being in one of two groups: sufficient and deficient
Those with an average of 40 ng/ml of vitamin D did MUCH better than those with an average of only 17 ng/ml
2X fewer deaths after 5 years, lower blood pressure, less atrial fibrillation, less diabetes, lower weight, etc.
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James L. Vacek, MD, Msc jlvacek at mac.md; Subba Reddy Vanga, MBBS; Mathew Good, DO; Sue Min Lai, PhD; Dhanunjaya Lakkireddy, MD; Patricia A. Howard, PharmD
Received 18 July 2011; received in revised form 13 September 2011; accepted 13 September 2011. published online 10 November 2011. Americal Journal of Cardiology

Recent evidence supports an association between vitamin D deficiency and hypertension, peripheral vascular disease, diabetes mellitus, metabolic syndrome, coronary artery disease, and heart failure. The effect of vitamin D supplementation, however, has not been well studied. We examined the associations between vitamin D deficiency, vitamin D supplementation, and patient outcomes in a large cohort. Serum vitamin D measurements for 5 years and 8 months from a large academic institution were matched to patient demographic, physiologic, and disease variables.

The vitamin D levels were analyzed as a continuous variable and as normal (?30 ng/ml) or deficient (<30 ng/ml). Descriptive statistics, univariate analysis, multivariate analysis, survival analysis, and Cox proportional hazard modeling were performed.

Of 10,899 patients, the mean age was 58 ± 15 years, 71% were women (n = 7,758), and the average body mass index was 30 ± 8 kg/m2. The mean serum vitamin D level was 24.1 ± 13.6 ng/ml. Of the 10,899 patients, 3,294 (29.7%) were in the normal vitamin D range and 7,665 (70.3%) were deficient.

Vitamin D deficiency was associated with several cardiovascular-related diseases, including

  • hypertension,
  • coronary artery disease,
  • cardiomyopathy, and
  • diabetes (all p <0.05).


Vitamin D deficiency was a strong independent predictor of all-cause death
(odds ratios 2.64, 95% confidence interval 1.901 to 3.662, p <0.0001) after adjusting for multiple clinical variables.

Vitamin D supplementation conferred substantial survival benefit (odds ratio for death 0.39, 95% confidence interval 0.277 to 0.534, p <0.0001).

In conclusion, vitamin D deficiency was associated with a significant risk of cardiovascular disease and reduced survival.
Vitamin D supplementation was significantly associated with better survival, specifically in patients with documented deficiency.
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Cardiology patients who were vitamin D sufficient

- 23% took vitamin D: between 1,000 IU daily to 50,000 IU every two weeks:
- had average 40 ng/ml of vitamin D

The cardiology patients who were deficient had only 17 ng/ml

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The cardiology patients after 5 years:

  • 4 % died who had average of 40 ng of vitamin D
  • 8 % died who had average of 17 ng of vitamin D

There were many measurable benefits of extra vitamin D

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If registered (free) CLICK HERE for PDF

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See also VitaminDWiki

See also in VitaminDWiki Cardiovascular and MORTALITY

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=1784

See also in VitaminDWiki HYPERTENSION and BLOOD PRESSURE

Attached files

ID Name Comment Uploaded Size Downloads
966 cardiovascular T2B.jpg admin 25 Dec, 2011 32.98 Kb 1058
965 cardiovascular T2A.jpg admin 25 Dec, 2011 25.96 Kb 1097
964 Cardiovascular chart.jpg admin 25 Dec, 2011 33.11 Kb 1645
906 cardiologyt1b.jpg admin 29 Nov, 2011 48.50 Kb 978
905 cardiologyt1a.jpg admin 29 Nov, 2011 62.83 Kb 1097
904 death vs deficiency.jpg admin 29 Nov, 2011 56.41 Kb 1054