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Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017

Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders

Int. J. Mol. Sci. 2017, 18(11), 2340; doi:10.3390/ijms18112340
Julia Knabl 1,2, Aurelia Vattai 1, Yao Ye 1, Julia Jueckstock 1, Stefan Hutter 1, Franz Kainer 2, Sven Mahner 1 and Udo Jeschke 1,* OrcID
1 Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany
2 Department of Obstetrics and Gynecology, Klinik Hallerwiese, 90419 Nürnberg, Germany
(This article belongs to the Special Issue Vitamin D and Its Analogues: New Insights on Biological Effects and Therapeutic Uses)

 Download the PDF from VitaminDWiki

Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It

  • regulates decidualisation and implantation,
  • influences hormone secretion and
  • placental immune modulations.

This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as

  • preeclampsia,
  • fetal growth restriction    5 % of pregnancies
  • gestational diabetes    3% to 8% of pregnancies
  • preterm birth.

We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.

Clipped from PDF

  • “FokI variant could be linked to an increased risk of preterm birth (odds ratio OR = 3.317)”
    The above is the only quantitative data which was quickly noticed in the study
Created by admin. Last Modification: Monday November 20, 2017 15:08:10 UTC by admin. (Version 5)

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8684 Role of Placental VDR Expression and Function.pdf admin 10 Nov, 2017 03:17 709.05 Kb 2
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